diff --git a/src/google/protobuf/io/coded_stream.h b/src/google/protobuf/io/coded_stream.h
index b9c30fa3cb..978cc19de1 100644
--- a/src/google/protobuf/io/coded_stream.h
+++ b/src/google/protobuf/io/coded_stream.h
@@ -123,7 +123,8 @@
   #endif
 #else
   #include <sys/param.h>   // __BYTE_ORDER
-  #if defined(__BYTE_ORDER) && __BYTE_ORDER == __LITTLE_ENDIAN && \
+  #if ((defined(__LITTLE_ENDIAN__) && !defined(__BIG_ENDIAN__)) || \
+         (defined(__BYTE_ORDER) && __BYTE_ORDER == __LITTLE_ENDIAN)) && \
       !defined(PROTOBUF_DISABLE_LITTLE_ENDIAN_OPT_FOR_TEST)
     #define PROTOBUF_LITTLE_ENDIAN 1
   #endif