diff --git a/modules/gapi/test/cpu/gapi_core_tests_fluid.cpp b/modules/gapi/test/cpu/gapi_core_tests_fluid.cpp
index 18f106b2d9..8162e01f50 100644
--- a/modules/gapi/test/cpu/gapi_core_tests_fluid.cpp
+++ b/modules/gapi/test/cpu/gapi_core_tests_fluid.cpp
@@ -24,12 +24,35 @@ INSTANTIATE_TEST_CASE_P(MathOpTestFluid, MathOpTest,
                                        cv::Size(128, 128)),
                                 Values(-1, CV_8U, CV_32F),
                                 Values(CORE_FLUID),
-                                Values(ADD, SUB, DIV, MUL),
+                                Values(DIV, MUL),
                                 testing::Bool(),
                                 Values(1.0),
                                 testing::Bool()));
 
-INSTANTIATE_TEST_CASE_P(SubTestFluid, MathOpTest,
+// FIXME: Accuracy test for SUB math operation fails on FullHD and HD CV_16SC1 input cv::Mat,
+//        double-presicion input cv::Scalar and CV_32FC1 output cv::Mat on Mac.
+//        Accuracy test for ADD math operation fails on HD CV_16SC1 input cv::Mat,
+//        double-presicion input cv::Scalar and CV_32FC1 output cv::Mat on Mac.
+//        As failures are sporadic, disabling all instantiation cases for SUB and ADD.
+//        Github ticket: https://github.com/opencv/opencv/issues/18373.
+INSTANTIATE_TEST_CASE_P(DISABLED_MathOpTestFluid, MathOpTest,
+                        Combine(Values(CV_8UC3, CV_8UC1, CV_16SC1, CV_32FC1),
+                                Values(cv::Size(1920, 1080),
+                                       cv::Size(1280, 720),
+                                       cv::Size(640, 480),
+                                       cv::Size(128, 128)),
+                                Values(-1, CV_8U, CV_32F),
+                                Values(CORE_FLUID),
+                                Values(ADD, SUB),
+                                testing::Bool(),
+                                Values(1.0),
+                                testing::Bool()));
+
+// FIXME: Accuracy test for SUB math operation fails on CV_16SC1 input cv::Mat, double-presicion
+//        input cv::Scalar and CV_32FC1 output cv::Mat on Mac.
+//        As failures are sporadic, disabling all instantiation cases for SUB operation.
+//        Github ticket: https://github.com/opencv/opencv/issues/18373.
+INSTANTIATE_TEST_CASE_P(DISABLED_SubTestFluid, MathOpTest,
                         Combine(Values(CV_8UC1, CV_16SC1 , CV_32FC1),
                                 Values(cv::Size(1280, 720),
                                        cv::Size(640, 480),
diff --git a/modules/gapi/test/gpu/gapi_core_tests_gpu.cpp b/modules/gapi/test/gpu/gapi_core_tests_gpu.cpp
index 5b38722c3f..35daed7503 100644
--- a/modules/gapi/test/gpu/gapi_core_tests_gpu.cpp
+++ b/modules/gapi/test/gpu/gapi_core_tests_gpu.cpp
@@ -53,7 +53,17 @@ INSTANTIATE_TEST_CASE_P(SubTestGPU, MathOpTest,
                                 Values (1.0),
                                 testing::Bool()));
 
-INSTANTIATE_TEST_CASE_P(DivTestGPU, MathOpTest,
+// FIXME: Accuracy test for DIV math operation fails on CV_8UC3 HD input cv::Mat, double-presicion
+//        input cv::Scalar and CV_16U output cv::Mat when we also test reverse operation on Mac.
+//        Accuracy test for DIV math operation fails on CV_8UC3 VGA input cv::Mat, double-presicion
+//        input cv::Scalar and output cv::Mat having the SAME depth as input one when we also test
+//        reverse operation on Mac.
+//        It is oddly, but test doesn't fail if we have VGA CV_8UC3 input cv::Mat, double-precision
+//        input cv::Scalar and output cv::Mat having explicitly specified CV_8U depth when we also
+//        test reverse operation on Mac.
+//        As failures are sporadic, disabling all instantiation cases for DIV operation.
+//        Github ticket: https://github.com/opencv/opencv/issues/18373.
+INSTANTIATE_TEST_CASE_P(DISABLED_DivTestGPU, MathOpTest,
                         Combine(Values( CV_8UC1, CV_8UC3, CV_16UC1, CV_16SC1, CV_32FC1 ),
                                 Values(cv::Size(1280, 720),
                                        cv::Size(640, 480),