diff --git a/mesonbuild/dependencies.py b/mesonbuild/dependencies.py
index 32e13b78e..c894b0ebd 100644
--- a/mesonbuild/dependencies.py
+++ b/mesonbuild/dependencies.py
@@ -108,14 +108,14 @@ class PkgConfigDependency(Dependency):
         self.cargs = []
         self.libs = []
         if 'native' in kwargs and environment.is_cross_build():
-            want_cross = not kwargs['native']
+            self.want_cross = not kwargs['native']
         else:
-            want_cross = environment.is_cross_build()
+            self.want_cross = environment.is_cross_build()
         self.name = name
 
         # When finding dependencies for cross-compiling, we don't care about
         # the 'native' pkg-config
-        if want_cross:
+        if self.want_cross:
             if 'pkgconfig' not in environment.cross_info.config['binaries']:
                 if self.required:
                     raise DependencyException('Pkg-config binary missing from cross file')
@@ -142,7 +142,7 @@ class PkgConfigDependency(Dependency):
             if self.required:
                 raise DependencyException('Pkg-config not found.')
             return
-        if want_cross:
+        if self.want_cross:
             self.type_string = 'Cross'
         else:
             self.type_string = 'Native'
@@ -551,9 +551,9 @@ class BoostDependency(Dependency):
         self.environment = environment
         self.libdir = ''
         if 'native' in kwargs and environment.is_cross_build():
-            want_cross = not kwargs['native']
+            self.want_cross = not kwargs['native']
         else:
-            want_cross = environment.is_cross_build()
+            self.want_cross = environment.is_cross_build()
         try:
             self.boost_root = os.environ['BOOST_ROOT']
             if not os.path.isabs(self.boost_root):
@@ -561,7 +561,7 @@ class BoostDependency(Dependency):
         except KeyError:
             self.boost_root = None
         if self.boost_root is None:
-            if want_cross:
+            if self.want_cross:
                 raise DependencyException('BOOST_ROOT is needed while cross-compiling')
             if mesonlib.is_windows():
                 self.boost_root = self.detect_win_root()
diff --git a/mesonbuild/interpreter.py b/mesonbuild/interpreter.py
index cb5b6175d..007a7d516 100644
--- a/mesonbuild/interpreter.py
+++ b/mesonbuild/interpreter.py
@@ -1788,6 +1788,15 @@ class Interpreter(InterpreterBase):
             raise InvalidArguments('''Characters <, > and = are forbidden in target names. To specify version
 requirements use the version keyword argument instead.''')
         identifier = dependencies.get_dep_identifier(name, kwargs)
+        # Check if we want this as a cross-dep or a native-dep
+        # FIXME: Not all dependencies support such a distinction right now,
+        # and we repeat this check inside dependencies that do. We need to
+        # consolidate this somehow.
+        is_cross = self.environment.is_cross_build()
+        if 'native' in kwargs and is_cross:
+            want_cross = not kwargs['native']
+        else:
+            want_cross = is_cross
         # Check if we've already searched for and found this dep
         cached_dep = None
         if identifier in self.coredata.deps:
@@ -1804,6 +1813,9 @@ requirements use the version keyword argument instead.''')
             # so we properly go into fallback/error code paths
             if kwargs.get('required', True) and not getattr(cached_dep, 'required', False):
                 cached_dep = None
+            # Don't reuse cached dep if one is a cross-dep and the other is a native dep
+            if not getattr(cached_dep, 'want_cross', is_cross) == want_cross:
+                cached_dep = None
 
         if cached_dep:
             dep = cached_dep