The C based gRPC (C++, Python, Ruby, Objective-C, PHP, C#) https://grpc.io/
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SSL in gRPC and performance

The SSL requirement of gRPC isn't necessarily making it easy to integrate. The HTTP/2 protocol requires ALPN support, which is a fairly new handshake protocol only supported by recent implementations.

As a result, we've tried hard to provide a smooth experience to our users when compiling and distributing gRPC, but this may come at performance costs due to this. More specifically, we will sometime build the SSL library by disabling assembly code (by setting the OPENSSL_NO_ASM option), which can impact performance by an order of magnitude when processing encrypted streams.

gRPC C++: Building from Source

Build system Condition Platform Uses assembly optimizations
Makefile with OpenSSL 1.0.2 development files all
Makefile all other cases all
Bazel Linux
Bazel MacOS
Bazel Windows
CMake boringssl from submodule (default) Linux or MacOS
CMake boringssl from submodule (default), generator=Ninja Windows
CMake boringssl from submodule (default), generator=Visual Studio Windows
CMake pre-installed OpenSSL 1.0.2+ (gRPC_SSL_PROVIDER=package) all

Other Languages: Binary/Source Packages

In addition, we are shipping packages for language implementations. These packages are source packages, but also have pre-built binaries being distributed. Building packages from source may give a different result in some cases.

Language From source Platform Uses assembly optimizations
C# n/a Linux, 64bit
C# n/a Linux, 32bit
C# n/a MacOS
C# n/a Windows
Node.JS n/a Linux
Node.JS n/a MacOS
Node.JS n/a Windows
Electron n/a all
ObjC Yes iOS
PHP Yes all Same as the Makefile case from above
PHP No all
Python n/a all
Ruby No all