The C based gRPC (C++, Python, Ruby, Objective-C, PHP, C#) https://grpc.io/
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Background

In Python, multithreading is ineffective at concurrency for CPU bound tasks due to the GIL (global interpreter lock). Extension modules can release the GIL in CPU bound tasks, but that isn't an option in pure Python. Users use libraries such as multiprocessing, subprocess, concurrent.futures.ProcessPoolExecutor, etc, to work around the GIL. These modules call fork() underneath the hood. Various issues have been reported when using these modules with gRPC Python. gRPC Python wraps gRPC core, which uses multithreading for performance, and hence doesn't support fork(). Historically, we didn't support forking in gRPC, but some users seemed to be doing fine until their code started to break on version 1.6. This was likely caused by the addition of background c-threads and a background Python thread.

Current Status

gRPC Python applications can enable client-side forking when two environment variables are given:

export GRPC_ENABLE_FORK_SUPPORT=true
export GRPC_POLL_STRATEGY=poll

The fork-support effort only works with "epoll1" and "poll" polling strategy. There is no active development to extend fork-support's coverage.

For more details about poll strategy setting, see https://github.com/grpc/grpc/blob/master/doc/environment_variables.md.

Alternative: use after fork

Complexities mentioned in the background section are inevitable for "pre-fork" usage, where the application creates gRPC Python objects (e.g., client channel) before invoking fork(). However, if the application only instantiate gRPC Python objects after calling fork(), then fork() will work normally, since there is no C extension binding at this point. This idea is demonstrated by the multiprocessing example.