diff --git a/tools/dockerfile/grpc_artifact_python_manylinux2010_x64/Dockerfile b/tools/dockerfile/grpc_artifact_python_manylinux2010_x64/Dockerfile
deleted file mode 100644
index 51a6758385f..00000000000
--- a/tools/dockerfile/grpc_artifact_python_manylinux2010_x64/Dockerfile
+++ /dev/null
@@ -1,45 +0,0 @@
-# Copyright 2019 The gRPC Authors
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-
-# Docker file for building gRPC manylinux Python artifacts.
-
-FROM quay.io/pypa/manylinux2010_x86_64:2022-01-22-72ab18b
-
-# manylinux_2_12 is the preferred alias of manylinux2010
-ENV AUDITWHEEL_PLAT manylinux_2_12_$AUDITWHEEL_ARCH
-
-# TODO(jtattermusch): revisit which of the deps are really required
-RUN yum update -y && yum install -y curl-devel expat-devel gettext-devel linux-headers openssl-devel zlib-devel gcc
-
-###################################
-# Install Python build requirements
-RUN /opt/python/cp36-cp36m/bin/pip install --upgrade cython
-RUN /opt/python/cp37-cp37m/bin/pip install --upgrade cython
-RUN /opt/python/cp38-cp38/bin/pip install --upgrade cython
-RUN /opt/python/cp39-cp39/bin/pip install --upgrade cython
-RUN /opt/python/cp310-cp310/bin/pip install --upgrade cython
-
-#=================
-# Install ccache
-
-# Install ccache from source since ccache 3.x packaged with most linux distributions
-# does not support Redis backend for caching.
-RUN curl -sSL -o ccache.tar.gz https://github.com/ccache/ccache/releases/download/v4.5.1/ccache-4.5.1.tar.gz \
-    && tar -zxf ccache.tar.gz \
-    && cd ccache-4.5.1 \
-    && mkdir build && cd build \
-    && cmake -DCMAKE_BUILD_TYPE=Release -DZSTD_FROM_INTERNET=ON -DHIREDIS_FROM_INTERNET=ON .. \
-    && make -j4 && make install \
-    && cd ../.. \
-    && rm -rf ccache-4.5.1 ccache.tar.gz
diff --git a/tools/dockerfile/grpc_artifact_python_manylinux2010_x86/Dockerfile b/tools/dockerfile/grpc_artifact_python_manylinux2010_x86/Dockerfile
deleted file mode 100644
index a7e1815e2bd..00000000000
--- a/tools/dockerfile/grpc_artifact_python_manylinux2010_x86/Dockerfile
+++ /dev/null
@@ -1,45 +0,0 @@
-# Copyright 2019 The gRPC Authors
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-
-# Docker file for building gRPC manylinux Python artifacts.
-
-FROM quay.io/pypa/manylinux2010_i686:2022-01-22-72ab18b
-
-# manylinux_2_12 is the preferred alias of manylinux2010
-ENV AUDITWHEEL_PLAT manylinux_2_12_$AUDITWHEEL_ARCH
-
-# TODO(jtattermusch): revisit which of the deps are really required
-RUN yum update -y && yum install -y curl-devel expat-devel gettext-devel linux-headers openssl-devel zlib-devel gcc
-
-###################################
-# Install Python build requirements
-RUN /opt/python/cp36-cp36m/bin/pip install --upgrade cython
-RUN /opt/python/cp37-cp37m/bin/pip install --upgrade cython
-RUN /opt/python/cp38-cp38/bin/pip install --upgrade cython
-RUN /opt/python/cp39-cp39/bin/pip install --upgrade cython
-RUN /opt/python/cp310-cp310/bin/pip install --upgrade cython
-
-#=================
-# Install ccache
-
-# Install ccache from source since ccache 3.x packaged with most linux distributions
-# does not support Redis backend for caching.
-RUN curl -sSL -o ccache.tar.gz https://github.com/ccache/ccache/releases/download/v4.5.1/ccache-4.5.1.tar.gz \
-    && tar -zxf ccache.tar.gz \
-    && cd ccache-4.5.1 \
-    && mkdir build && cd build \
-    && cmake -DCMAKE_BUILD_TYPE=Release -DZSTD_FROM_INTERNET=ON -DHIREDIS_FROM_INTERNET=ON .. \
-    && make -j4 && make install \
-    && cd ../.. \
-    && rm -rf ccache-4.5.1 ccache.tar.gz
diff --git a/tools/run_tests/artifacts/artifact_targets.py b/tools/run_tests/artifacts/artifact_targets.py
index 2f91787d97f..355a296fed4 100644
--- a/tools/run_tests/artifacts/artifact_targets.py
+++ b/tools/run_tests/artifacts/artifact_targets.py
@@ -433,23 +433,15 @@ def targets():
         CSharpExtArtifact('linux', 'android', arch_abi='x86', presubmit=True),
         CSharpExtArtifact('macos', 'ios', presubmit=True),
         PythonArtifact('manylinux2014', 'x64', 'cp36-cp36m', presubmit=True),
-        PythonArtifact('manylinux2014', 'x64', 'cp37-cp37m'),
+        PythonArtifact('manylinux2014', 'x64', 'cp37-cp37m', presubmit=True),
         PythonArtifact('manylinux2014', 'x64', 'cp38-cp38'),
         PythonArtifact('manylinux2014', 'x64', 'cp39-cp39'),
         PythonArtifact('manylinux2014', 'x64', 'cp310-cp310', presubmit=True),
         PythonArtifact('manylinux2014', 'x86', 'cp36-cp36m', presubmit=True),
-        PythonArtifact('manylinux2014', 'x86', 'cp37-cp37m'),
+        PythonArtifact('manylinux2014', 'x86', 'cp37-cp37m', presubmit=True),
         PythonArtifact('manylinux2014', 'x86', 'cp38-cp38'),
         PythonArtifact('manylinux2014', 'x86', 'cp39-cp39'),
         PythonArtifact('manylinux2014', 'x86', 'cp310-cp310', presubmit=True),
-        PythonArtifact('manylinux2010', 'x64', 'cp36-cp36m'),
-        PythonArtifact('manylinux2010', 'x64', 'cp37-cp37m', presubmit=True),
-        PythonArtifact('manylinux2010', 'x64', 'cp38-cp38'),
-        PythonArtifact('manylinux2010', 'x64', 'cp39-cp39'),
-        PythonArtifact('manylinux2010', 'x86', 'cp36-cp36m'),
-        PythonArtifact('manylinux2010', 'x86', 'cp37-cp37m', presubmit=True),
-        PythonArtifact('manylinux2010', 'x86', 'cp38-cp38'),
-        PythonArtifact('manylinux2010', 'x86', 'cp39-cp39'),
         PythonArtifact('manylinux2014', 'aarch64', 'cp36-cp36m',
                        presubmit=True),
         PythonArtifact('manylinux2014', 'aarch64', 'cp37-cp37m'),