diff --git a/include/grpc/impl/codegen/port_platform.h b/include/grpc/impl/codegen/port_platform.h
index 0da45acab57..af114de4153 100644
--- a/include/grpc/impl/codegen/port_platform.h
+++ b/include/grpc/impl/codegen/port_platform.h
@@ -534,6 +534,14 @@ typedef unsigned __int64 uint64_t;
 #endif
 #endif /* GPR_HAS_ATTRIBUTE */
 
+#ifndef GPR_HAS_FEATURE
+#ifdef __has_feature
+#define GPR_HAS_FEATURE(a) __has_feature(a)
+#else
+#define GPR_HAS_FEATURE(a) 0
+#endif
+#endif /* GPR_HAS_FEATURE */
+
 #ifndef GPR_ATTRIBUTE_NOINLINE
 #if GPR_HAS_ATTRIBUTE(noinline) || (defined(__GNUC__) && !defined(__clang__))
 #define GPR_ATTRIBUTE_NOINLINE __attribute__((noinline))
@@ -569,10 +577,15 @@ typedef unsigned __int64 uint64_t;
 /* GRPC_TSAN_ENABLED will be defined, when compiled with thread sanitizer. */
 #if defined(__SANITIZE_THREAD__)
 #define GRPC_TSAN_ENABLED
-#elif defined(__has_feature)
-#if __has_feature(thread_sanitizer)
+#elif GPR_HAS_FEATURE(thread_sanitizer)
 #define GRPC_TSAN_ENABLED
 #endif
+
+/* GRPC_ASAN_ENABLED will be defined, when compiled with address sanitizer. */
+#if defined(__SANITIZE_ADDRESS__)
+#define GRPC_ASAN_ENABLED
+#elif GPR_HAS_FEATURE(address_sanitizer)
+#define GRPC_ASAN_ENABLED
 #endif
 
 /* GRPC_ALLOW_EXCEPTIONS should be 0 or 1 if exceptions are allowed or not */
diff --git a/include/grpc/impl/codegen/sync_posix.h b/include/grpc/impl/codegen/sync_posix.h
index d927046c53e..cf95e4c6345 100644
--- a/include/grpc/impl/codegen/sync_posix.h
+++ b/include/grpc/impl/codegen/sync_posix.h
@@ -25,8 +25,26 @@
 
 #include <pthread.h>
 
+#ifdef GRPC_ASAN_ENABLED
+/* The member |leak_checker| is used to check whether there is memory leak
+ * that may be caused by upper layer logic which missing the |gpr_xx_destroy|
+ * call to this object before freeing.
+ * This issue was reported at https://github.com/grpc/grpc/issues/17563
+ * and discussed at https://github.com/grpc/grpc/pull/17586
+ */
+typedef struct {
+  pthread_mutex_t mutex;
+  int *leak_checker;
+} gpr_mu;
+
+typedef struct {
+  pthread_cond_t cond_var;
+  int *leak_checker;
+} gpr_cv;
+#else
 typedef pthread_mutex_t gpr_mu;
 typedef pthread_cond_t gpr_cv;
+#endif
 typedef pthread_once_t gpr_once;
 
 #define GPR_ONCE_INIT PTHREAD_ONCE_INIT
diff --git a/src/core/lib/gpr/sync_posix.cc b/src/core/lib/gpr/sync_posix.cc
index c09a7598acb..a915bbfad95 100644
--- a/src/core/lib/gpr/sync_posix.cc
+++ b/src/core/lib/gpr/sync_posix.cc
@@ -17,6 +17,7 @@
  */
 
 #include <grpc/support/port_platform.h>
+#include <grpc/support/alloc.h>
 
 #ifdef GPR_POSIX_SYNC
 
@@ -72,27 +73,58 @@ gpr_atm gpr_counter_atm_add = 0;
 #endif
 
 void gpr_mu_init(gpr_mu* mu) {
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_mutex_init(&mu->mutex, nullptr) == 0);
+  mu->leak_checker = (int*)gpr_malloc(sizeof(*mu->leak_checker));
+  GPR_ASSERT(mu->leak_checker != nullptr);
+  /* Initial it with a magic number, make no sense, just use the memory.
+  * This only take effect when ASAN enabled, so,
+  * if memory allocation failed, let it crash.
+  */
+  *mu->leak_checker = 0x12F34D0;
+#else
   GPR_ASSERT(pthread_mutex_init(mu, nullptr) == 0);
+#endif
 }
 
-void gpr_mu_destroy(gpr_mu* mu) { GPR_ASSERT(pthread_mutex_destroy(mu) == 0); }
+void gpr_mu_destroy(gpr_mu* mu) {
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_mutex_destroy(&mu->mutex) == 0);
+  gpr_free(mu->leak_checker);
+#else
+  GPR_ASSERT(pthread_mutex_destroy(mu) == 0);
+#endif
+}
 
 void gpr_mu_lock(gpr_mu* mu) {
 #ifdef GPR_LOW_LEVEL_COUNTERS
   GPR_ATM_INC_COUNTER(gpr_mu_locks);
 #endif
   GPR_TIMER_SCOPE("gpr_mu_lock", 0);
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_mutex_lock(&mu->mutex) == 0);
+#else
   GPR_ASSERT(pthread_mutex_lock(mu) == 0);
+#endif
 }
 
 void gpr_mu_unlock(gpr_mu* mu) {
   GPR_TIMER_SCOPE("gpr_mu_unlock", 0);
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_mutex_unlock(&mu->mutex) == 0);
+#else
   GPR_ASSERT(pthread_mutex_unlock(mu) == 0);
+#endif
 }
 
 int gpr_mu_trylock(gpr_mu* mu) {
   GPR_TIMER_SCOPE("gpr_mu_trylock", 0);
-  int err = pthread_mutex_trylock(mu);
+  int err = 0;
+#ifdef GRPC_ASAN_ENABLED
+  err = pthread_mutex_trylock(&mu->mutex);
+#else
+  err = pthread_mutex_trylock(mu);
+#endif
   GPR_ASSERT(err == 0 || err == EBUSY);
   return err == 0;
 }
@@ -105,10 +137,29 @@ void gpr_cv_init(gpr_cv* cv) {
 #if GPR_LINUX
   GPR_ASSERT(pthread_condattr_setclock(&attr, CLOCK_MONOTONIC) == 0);
 #endif  // GPR_LINUX
+
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_cond_init(&cv->cond_var, &attr) == 0);
+  cv->leak_checker = (int*)gpr_malloc(sizeof(*cv->leak_checker));
+  GPR_ASSERT(cv->leak_checker != nullptr);
+  /* Initial it with a magic number, make no sense, just use the memory.
+  * This only take effect when ASAN enabled, so,
+  * if memory allocation failed, let it crash.
+  */
+  *cv->leak_checker = 0x12F34D0;
+#else
   GPR_ASSERT(pthread_cond_init(cv, &attr) == 0);
+#endif
 }
 
-void gpr_cv_destroy(gpr_cv* cv) { GPR_ASSERT(pthread_cond_destroy(cv) == 0); }
+void gpr_cv_destroy(gpr_cv* cv) {
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_cond_destroy(&cv->cond_var) == 0);
+  gpr_free(cv->leak_checker);
+#else
+  GPR_ASSERT(pthread_cond_destroy(cv) == 0);
+#endif
+}
 
 // For debug of the timer manager crash only.
 // TODO (mxyan): remove after bug is fixed.
@@ -169,7 +220,11 @@ int gpr_cv_wait(gpr_cv* cv, gpr_mu* mu, gpr_timespec abs_deadline) {
 #endif
   if (gpr_time_cmp(abs_deadline, gpr_inf_future(abs_deadline.clock_type)) ==
       0) {
+#ifdef GRPC_ASAN_ENABLED
+    err = pthread_cond_wait(&cv->cond_var, &mu->mutex);
+#else
     err = pthread_cond_wait(cv, mu);
+#endif
   } else {
     struct timespec abs_deadline_ts;
 #if GPR_LINUX
@@ -181,7 +236,13 @@ int gpr_cv_wait(gpr_cv* cv, gpr_mu* mu, gpr_timespec abs_deadline) {
 #endif  // GPR_LINUX
     abs_deadline_ts.tv_sec = static_cast<time_t>(abs_deadline.tv_sec);
     abs_deadline_ts.tv_nsec = abs_deadline.tv_nsec;
+
+#ifdef GRPC_ASAN_ENABLED
+    err = pthread_cond_timedwait(&cv->cond_var, &mu->mutex, &abs_deadline_ts);
+#else
     err = pthread_cond_timedwait(cv, mu, &abs_deadline_ts);
+#endif
+
 #ifdef GRPC_DEBUG_TIMER_MANAGER
     // For debug of the timer manager crash only.
     // TODO (mxyan): remove after bug is fixed.
@@ -226,10 +287,20 @@ int gpr_cv_wait(gpr_cv* cv, gpr_mu* mu, gpr_timespec abs_deadline) {
   return err == ETIMEDOUT;
 }
 
-void gpr_cv_signal(gpr_cv* cv) { GPR_ASSERT(pthread_cond_signal(cv) == 0); }
+void gpr_cv_signal(gpr_cv* cv) {
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_cond_signal(&cv->cond_var) == 0);
+#else
+  GPR_ASSERT(pthread_cond_signal(cv) == 0);
+#endif
+}
 
 void gpr_cv_broadcast(gpr_cv* cv) {
+#ifdef GRPC_ASAN_ENABLED
+  GPR_ASSERT(pthread_cond_broadcast(&cv->cond_var) == 0);
+#else
   GPR_ASSERT(pthread_cond_broadcast(cv) == 0);
+#endif
 }
 
 /*----------------------------------------*/