diff --git a/tools/interop_matrix/client_matrix.py b/tools/interop_matrix/client_matrix.py
index 18e934167cb..131c4a789e2 100644
--- a/tools/interop_matrix/client_matrix.py
+++ b/tools/interop_matrix/client_matrix.py
@@ -31,6 +31,7 @@ LANG_RUNTIME_MATRIX = {
     'node': ['node'],
     'ruby': ['ruby'],
     'php': ['php', 'php7'],
+    'csharp': ['csharp', 'csharpcoreclr'],
 }
 
 # Dictionary of releases per language.  For each language, we need to provide
@@ -95,4 +96,13 @@ LANG_RELEASE_MATRIX = {
         'v1.4.2',
         'v1.6.6',
     ],
+   'csharp': [
+        # Fail to build docker image with v1.3.9 and earlier.
+        #'v1.0.1',
+        #'v1.1.4',
+        #'v1.2.5',
+        #'v1.3.9',
+        'v1.4.2',
+        'v1.6.6',
+    ],
 }
diff --git a/tools/interop_matrix/testcases/csharp__master b/tools/interop_matrix/testcases/csharp__master
new file mode 100755
index 00000000000..32f6b380418
--- /dev/null
+++ b/tools/interop_matrix/testcases/csharp__master
@@ -0,0 +1,20 @@
+#!/bin/bash
+echo "Testing ${docker_image:=grpc_interop_csharp:a95229ca-d387-4127-ad48-69a7464e23b8}"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=large_unary"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_unary"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=ping_pong"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_stream"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=client_streaming"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=server_streaming"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_begin"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_first_response"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=timeout_on_sleeping_server"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=large_unary"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_unary"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=ping_pong"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_stream"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=client_streaming"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=server_streaming"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_begin"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_first_response"
+docker run -i --rm=true -w /var/local/git/grpc/src/csharp/Grpc.IntegrationTesting.Client/bin/Debug/net45 --net=host $docker_image bash -c "mono Grpc.IntegrationTesting.Client.exe --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=timeout_on_sleeping_server"