diff --git a/setup.py b/setup.py
index 94aa7793a79..613959550d4 100644
--- a/setup.py
+++ b/setup.py
@@ -293,6 +293,11 @@ if EXTRA_ENV_LINK_ARGS is None:
     if "linux" in sys.platform:
         EXTRA_ENV_LINK_ARGS += " -static-libgcc"
 
+# Explicitly link Core Foundation framework for MacOS to ensure no symbol is
+# missing when compiled using package managers like Conda.
+if "darwin" in sys.platform:
+    EXTRA_ENV_LINK_ARGS += " -framework CoreFoundation"
+
 EXTRA_COMPILE_ARGS = shlex.split(EXTRA_ENV_COMPILE_ARGS)
 EXTRA_LINK_ARGS = shlex.split(EXTRA_ENV_LINK_ARGS)
 
diff --git a/tools/distrib/python/grpcio_tools/setup.py b/tools/distrib/python/grpcio_tools/setup.py
index 5d6b8a0a974..c5c7243d233 100644
--- a/tools/distrib/python/grpcio_tools/setup.py
+++ b/tools/distrib/python/grpcio_tools/setup.py
@@ -190,6 +190,11 @@ if EXTRA_ENV_LINK_ARGS is None:
         if check_linker_need_libatomic():
             EXTRA_ENV_LINK_ARGS += " -latomic"
 
+# Explicitly link Core Foundation framework for MacOS to ensure no symbol is
+# missing when compiled using package managers like Conda.
+if "darwin" in sys.platform:
+    EXTRA_ENV_LINK_ARGS += " -framework CoreFoundation"
+
 EXTRA_COMPILE_ARGS = shlex.split(EXTRA_ENV_COMPILE_ARGS)
 EXTRA_LINK_ARGS = shlex.split(EXTRA_ENV_LINK_ARGS)