diff --git a/src/core/ext/filters/client_channel/xds/xds_api.cc b/src/core/ext/filters/client_channel/xds/xds_api.cc
index 69490b776fd..d4c2f380f50 100644
--- a/src/core/ext/filters/client_channel/xds/xds_api.cc
+++ b/src/core/ext/filters/client_channel/xds/xds_api.cc
@@ -1081,6 +1081,13 @@ grpc_error* RouteConfigParse(
     const envoy_api_v2_route_Route* route = routes[i];
     const envoy_api_v2_route_RouteMatch* match =
         envoy_api_v2_route_Route_match(route);
+    const google_protobuf_BoolValue* case_sensitive =
+        envoy_api_v2_route_RouteMatch_case_sensitive(match);
+    if (case_sensitive != nullptr &&
+        !google_protobuf_BoolValue_value(case_sensitive)) {
+      return GRPC_ERROR_CREATE_FROM_STATIC_STRING(
+          "case_sensitive if set must be set to true.");
+    }
     XdsApi::RdsUpdate::RdsRoute rds_route;
     if (envoy_api_v2_route_RouteMatch_has_prefix(match)) {
       upb_strview prefix = envoy_api_v2_route_RouteMatch_prefix(match);
diff --git a/src/proto/grpc/testing/xds/lds_rds_for_test.proto b/src/proto/grpc/testing/xds/lds_rds_for_test.proto
index ec2a46b7c88..a4d48b28d1a 100644
--- a/src/proto/grpc/testing/xds/lds_rds_for_test.proto
+++ b/src/proto/grpc/testing/xds/lds_rds_for_test.proto
@@ -29,6 +29,10 @@ import "google/protobuf/any.proto";
 import "google/protobuf/wrappers.proto";
 import "src/proto/grpc/testing/xds/cds_for_test.proto";
 
+message BoolValue {
+  // The bool value.
+  bool value = 1;
+}
 
 message RouteMatch {
   oneof path_specifier {
@@ -37,6 +41,7 @@ message RouteMatch {
     string prefix = 1;
     string path = 2;
   }
+  BoolValue case_sensitive = 4;
 }
 
 message WeightedCluster {
diff --git a/test/cpp/end2end/xds_end2end_test.cc b/test/cpp/end2end/xds_end2end_test.cc
index a163c49c24a..688d6cfd987 100644
--- a/test/cpp/end2end/xds_end2end_test.cc
+++ b/test/cpp/end2end/xds_end2end_test.cc
@@ -2004,6 +2004,26 @@ TEST_P(XdsResolverOnlyTest, DefaultRouteSpecifiesSlashPrefix) {
   WaitForAllBackends();
 }
 
+TEST_P(XdsResolverOnlyTest, DefaultRouteCaseInsensitive) {
+  RouteConfiguration route_config =
+      balancers_[0]->ads_service()->default_route_config();
+  route_config.mutable_virtual_hosts(0)
+      ->mutable_routes(0)
+      ->mutable_match()
+      ->mutable_case_sensitive()
+      ->set_value(false);
+  balancers_[0]->ads_service()->SetLdsResource(
+      AdsServiceImpl::BuildListener(route_config));
+  SetNextResolution({});
+  SetNextResolutionForLbChannelAllBalancers();
+  AdsServiceImpl::EdsResourceArgs args({
+      {"locality0", GetBackendPorts()},
+  });
+  balancers_[0]->ads_service()->SetEdsResource(
+      AdsServiceImpl::BuildEdsResource(args));
+  CheckRpcSendOk(5, RpcOptions().set_wait_for_ready(true));
+}
+
 class XdsResolverLoadReportingOnlyTest : public XdsEnd2endTest {
  public:
   XdsResolverLoadReportingOnlyTest() : XdsEnd2endTest(4, 1, 3) {}
@@ -2390,6 +2410,29 @@ TEST_P(LdsRdsTest, RouteMatchHasUnsupportedSpecifier) {
             "No prefix field found in Default RouteMatch.");
 }
 
+// Tests that LDS client should send a NACK if route match has a case_sensitive
+// set to false.
+TEST_P(LdsRdsTest, RouteMatchHasCaseSensitiveFalse) {
+  gpr_setenv("GRPC_XDS_EXPERIMENTAL_ROUTING", "true");
+  RouteConfiguration route_config =
+      balancers_[0]->ads_service()->default_route_config();
+  auto* route1 = route_config.mutable_virtual_hosts(0)->mutable_routes(0);
+  route1->mutable_match()->set_prefix("/grpc.testing.EchoTest1Service/");
+  route1->mutable_match()->mutable_case_sensitive()->set_value(false);
+  auto* default_route = route_config.mutable_virtual_hosts(0)->add_routes();
+  default_route->mutable_match()->set_prefix("");
+  default_route->mutable_route()->set_cluster(kDefaultResourceName);
+  SetRouteConfiguration(0, route_config);
+  SetNextResolution({});
+  SetNextResolutionForLbChannelAllBalancers();
+  CheckRpcSendFailure();
+  const auto& response_state = RouteConfigurationResponseState(0);
+  EXPECT_EQ(response_state.state, AdsServiceImpl::ResponseState::NACKED);
+  EXPECT_EQ(response_state.error_message,
+            "case_sensitive if set must be set to true.");
+  gpr_unsetenv("GRPC_XDS_EXPERIMENTAL_ROUTING");
+}
+
 // Tests that LDS client should send a NACK if route match has a prefix
 // string with no "/".
 TEST_P(LdsRdsTest, RouteMatchHasInvalidPrefixNonEmptyNoSlash) {