diff --git a/tools/dockerfile/grpc_artifact_linux_x64/Dockerfile b/tools/dockerfile/grpc_artifact_linux_x64/Dockerfile
index b3c16951229..d0faf057679 100644
--- a/tools/dockerfile/grpc_artifact_linux_x64/Dockerfile
+++ b/tools/dockerfile/grpc_artifact_linux_x64/Dockerfile
@@ -84,7 +84,7 @@ RUN apt-get update && apt-get install -t jessie-backports -y cmake && apt-get cl
 # Python AuditWheel dependencies (needed to check manylinux1 compatibility)
 
 RUN apt-get install -y python3 python3-pip
-RUN pip3 install auditwheel==1.10.0
+RUN pip3 install auditwheel==2.1.1
 
 
 RUN mkdir /var/local/jenkins
diff --git a/tools/dockerfile/grpc_artifact_linux_x86/Dockerfile b/tools/dockerfile/grpc_artifact_linux_x86/Dockerfile
index c9054653067..8738137f5b2 100644
--- a/tools/dockerfile/grpc_artifact_linux_x86/Dockerfile
+++ b/tools/dockerfile/grpc_artifact_linux_x86/Dockerfile
@@ -77,7 +77,7 @@ RUN apt-get update && apt-get install -t jessie-backports -y cmake && apt-get cl
 # Python AuditWheel dependencies (needed to check manylinux1 compatibility)
 
 RUN apt-get install -y python3 python3-pip
-RUN pip3 install auditwheel==1.10.0
+RUN pip3 install auditwheel==2.1.1
 
 
 RUN mkdir /var/local/jenkins
diff --git a/tools/dockerfile/grpc_artifact_python_manylinux_x64/Dockerfile b/tools/dockerfile/grpc_artifact_python_manylinux1_x64/Dockerfile
similarity index 74%
rename from tools/dockerfile/grpc_artifact_python_manylinux_x64/Dockerfile
rename to tools/dockerfile/grpc_artifact_python_manylinux1_x64/Dockerfile
index c36ad6bec58..1ff6aa062a2 100644
--- a/tools/dockerfile/grpc_artifact_python_manylinux_x64/Dockerfile
+++ b/tools/dockerfile/grpc_artifact_python_manylinux1_x64/Dockerfile
@@ -28,11 +28,4 @@ RUN /opt/python/cp34-cp34m/bin/pip install cython
 RUN /opt/python/cp35-cp35m/bin/pip install cython
 RUN /opt/python/cp36-cp36m/bin/pip install cython
 RUN /opt/python/cp37-cp37m/bin/pip install cython
-
-####################################################
-# Install auditwheel with fix for namespace packages
-RUN git clone https://github.com/pypa/auditwheel /usr/local/src/auditwheel
-RUN cd /usr/local/src/auditwheel && git checkout 2.1
-RUN /opt/python/cp36-cp36m/bin/pip install /usr/local/src/auditwheel
-RUN rm /usr/local/bin/auditwheel
-RUN cd /usr/local/bin && ln -s /opt/python/cp36-cp36m/bin/auditwheel
+RUN /opt/python/cp38-cp38/bin/pip install cython
diff --git a/tools/dockerfile/grpc_artifact_python_manylinux_x86/Dockerfile b/tools/dockerfile/grpc_artifact_python_manylinux1_x86/Dockerfile
similarity index 74%
rename from tools/dockerfile/grpc_artifact_python_manylinux_x86/Dockerfile
rename to tools/dockerfile/grpc_artifact_python_manylinux1_x86/Dockerfile
index a33e0517ae2..18b4cb62927 100644
--- a/tools/dockerfile/grpc_artifact_python_manylinux_x86/Dockerfile
+++ b/tools/dockerfile/grpc_artifact_python_manylinux1_x86/Dockerfile
@@ -28,12 +28,5 @@ RUN /opt/python/cp34-cp34m/bin/pip install cython
 RUN /opt/python/cp35-cp35m/bin/pip install cython
 RUN /opt/python/cp36-cp36m/bin/pip install cython
 RUN /opt/python/cp37-cp37m/bin/pip install cython
-
-####################################################
-# Install auditwheel with fix for namespace packages
-RUN git clone https://github.com/pypa/auditwheel /usr/local/src/auditwheel
-RUN cd /usr/local/src/auditwheel && git checkout 2.1
-RUN /opt/python/cp36-cp36m/bin/pip install /usr/local/src/auditwheel
-RUN rm /usr/local/bin/auditwheel
-RUN cd /usr/local/bin && ln -s /opt/python/cp36-cp36m/bin/auditwheel
-
+RUN /opt/python/cp37-cp37m/bin/pip install cython
+RUN /opt/python/cp38-cp38/bin/pip install cython
diff --git a/tools/dockerfile/grpc_artifact_python_manylinux2010_x64/Dockerfile b/tools/dockerfile/grpc_artifact_python_manylinux2010_x64/Dockerfile
new file mode 100644
index 00000000000..66aefcaac28
--- /dev/null
+++ b/tools/dockerfile/grpc_artifact_python_manylinux2010_x64/Dockerfile
@@ -0,0 +1,32 @@
+# Copyright 2019 The gRPC Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+# Docker file for building gRPC manylinux Python artifacts.
+
+FROM quay.io/pypa/manylinux2010_x86_64
+
+# Update the package manager
+RUN yum update -y
+RUN yum install -y curl-devel expat-devel gettext-devel linux-headers openssl-devel zlib-devel gcc
+
+###################################
+# Install Python build requirements
+RUN /opt/python/cp27-cp27m/bin/pip install cython
+RUN /opt/python/cp27-cp27mu/bin/pip install cython
+RUN /opt/python/cp34-cp34m/bin/pip install cython
+RUN /opt/python/cp35-cp35m/bin/pip install cython
+RUN /opt/python/cp36-cp36m/bin/pip install cython
+RUN /opt/python/cp37-cp37m/bin/pip install cython
+RUN /opt/python/cp37-cp37m/bin/pip install cython
+RUN /opt/python/cp38-cp38/bin/pip install cython
diff --git a/tools/dockerfile/grpc_artifact_python_manylinux2010_x86/Dockerfile b/tools/dockerfile/grpc_artifact_python_manylinux2010_x86/Dockerfile
new file mode 100644
index 00000000000..f55a8785182
--- /dev/null
+++ b/tools/dockerfile/grpc_artifact_python_manylinux2010_x86/Dockerfile
@@ -0,0 +1,32 @@
+# Copyright 2019 The gRPC Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+# Docker file for building gRPC manylinux Python artifacts.
+
+FROM quay.io/pypa/manylinux2010_i686
+
+# Update the package manager
+RUN yum update -y
+RUN yum install -y curl-devel expat-devel gettext-devel linux-headers openssl-devel zlib-devel gcc
+
+###################################
+# Install Python build requirements
+RUN /opt/python/cp27-cp27m/bin/pip install cython
+RUN /opt/python/cp27-cp27mu/bin/pip install cython
+RUN /opt/python/cp34-cp34m/bin/pip install cython
+RUN /opt/python/cp35-cp35m/bin/pip install cython
+RUN /opt/python/cp36-cp36m/bin/pip install cython
+RUN /opt/python/cp37-cp37m/bin/pip install cython
+RUN /opt/python/cp37-cp37m/bin/pip install cython
+RUN /opt/python/cp38-cp38/bin/pip install cython
diff --git a/tools/run_tests/artifacts/artifact_targets.py b/tools/run_tests/artifacts/artifact_targets.py
index aa1d0c3bf22..762c1a32399 100644
--- a/tools/run_tests/artifacts/artifact_targets.py
+++ b/tools/run_tests/artifacts/artifact_targets.py
@@ -110,6 +110,8 @@ class PythonArtifact:
         self.arch = arch
         self.labels = ['artifact', 'python', platform, arch, py_version]
         self.py_version = py_version
+        if 'manylinux' in platform:
+            self.labels.append('linux')
 
     def pre_build_jobspecs(self):
         return []
@@ -135,7 +137,7 @@ class PythonArtifact:
                 timeout_seconds=60 * 60 * 5,
                 docker_base_image='quay.io/grpc/raspbian_{}'.format(self.arch),
                 extra_docker_args=extra_args)
-        elif self.platform == 'linux':
+        elif 'manylinux' in self.platform:
             if self.arch == 'x86':
                 environ['SETARCH_CMD'] = 'linux32'
             # Inside the manylinux container, the python installations are located in
@@ -150,10 +152,11 @@ class PythonArtifact:
             environ['CFLAGS'] = '-DGPR_MANYLINUX1=1'
             environ['GRPC_BUILD_GRPCIO_TOOLS_DEPENDENTS'] = 'TRUE'
             environ['GRPC_BUILD_MANYLINUX_WHEEL'] = 'TRUE'
+
             return create_docker_jobspec(
                 self.name,
-                'tools/dockerfile/grpc_artifact_python_manylinux_%s' %
-                self.arch,
+                'tools/dockerfile/grpc_artifact_python_%s_%s' % (self.platform,
+                                                                 self.arch),
                 'tools/run_tests/artifacts/build_artifact_python.sh',
                 environ=environ,
                 timeout_seconds=60 * 60,
@@ -360,12 +363,14 @@ def targets():
         CSharpExtArtifact('linux', 'android', arch_abi='armeabi-v7a'),
         CSharpExtArtifact('linux', 'android', arch_abi='x86'),
         CSharpExtArtifact('macos', 'ios'),
-        PythonArtifact('linux', 'x86', 'cp27-cp27m'),
-        PythonArtifact('linux', 'x86', 'cp27-cp27mu'),
-        PythonArtifact('linux', 'x86', 'cp34-cp34m'),
-        PythonArtifact('linux', 'x86', 'cp35-cp35m'),
-        PythonArtifact('linux', 'x86', 'cp36-cp36m'),
-        PythonArtifact('linux', 'x86', 'cp37-cp37m'),
+        # TODO(https://github.com/grpc/grpc/issues/20283)
+        # Add manylinux2010_x86 targets once this issue is resolved.
+        PythonArtifact('manylinux1', 'x86', 'cp27-cp27m'),
+        PythonArtifact('manylinux1', 'x86', 'cp27-cp27mu'),
+        PythonArtifact('manylinux1', 'x86', 'cp34-cp34m'),
+        PythonArtifact('manylinux1', 'x86', 'cp35-cp35m'),
+        PythonArtifact('manylinux1', 'x86', 'cp36-cp36m'),
+        PythonArtifact('manylinux1', 'x86', 'cp37-cp37m'),
         PythonArtifact('linux_extra', 'armv7', '2.7'),
         PythonArtifact('linux_extra', 'armv7', '3.4'),
         PythonArtifact('linux_extra', 'armv7', '3.5'),
@@ -374,12 +379,18 @@ def targets():
         PythonArtifact('linux_extra', 'armv6', '3.4'),
         PythonArtifact('linux_extra', 'armv6', '3.5'),
         PythonArtifact('linux_extra', 'armv6', '3.6'),
-        PythonArtifact('linux', 'x64', 'cp27-cp27m'),
-        PythonArtifact('linux', 'x64', 'cp27-cp27mu'),
-        PythonArtifact('linux', 'x64', 'cp34-cp34m'),
-        PythonArtifact('linux', 'x64', 'cp35-cp35m'),
-        PythonArtifact('linux', 'x64', 'cp36-cp36m'),
-        PythonArtifact('linux', 'x64', 'cp37-cp37m'),
+        PythonArtifact('manylinux1', 'x64', 'cp27-cp27m'),
+        PythonArtifact('manylinux1', 'x64', 'cp27-cp27mu'),
+        PythonArtifact('manylinux1', 'x64', 'cp34-cp34m'),
+        PythonArtifact('manylinux1', 'x64', 'cp35-cp35m'),
+        PythonArtifact('manylinux1', 'x64', 'cp36-cp36m'),
+        PythonArtifact('manylinux1', 'x64', 'cp37-cp37m'),
+        PythonArtifact('manylinux2010', 'x64', 'cp27-cp27m'),
+        PythonArtifact('manylinux2010', 'x64', 'cp27-cp27mu'),
+        PythonArtifact('manylinux2010', 'x64', 'cp34-cp34m'),
+        PythonArtifact('manylinux2010', 'x64', 'cp35-cp35m'),
+        PythonArtifact('manylinux2010', 'x64', 'cp36-cp36m'),
+        PythonArtifact('manylinux2010', 'x64', 'cp37-cp37m'),
         PythonArtifact('macos', 'x64', 'python2.7'),
         PythonArtifact('macos', 'x64', 'python3.4'),
         PythonArtifact('macos', 'x64', 'python3.5'),
diff --git a/tools/run_tests/artifacts/build_artifact_python.sh b/tools/run_tests/artifacts/build_artifact_python.sh
index 7393b88a768..1fc7fd67a6f 100755
--- a/tools/run_tests/artifacts/build_artifact_python.sh
+++ b/tools/run_tests/artifacts/build_artifact_python.sh
@@ -79,12 +79,12 @@ ${SETARCH_CMD} "${PYTHON}" tools/distrib/python/grpcio_tools/setup.py bdist_whee
 if [ "$GRPC_BUILD_MANYLINUX_WHEEL" != "" ]
 then
   for wheel in dist/*.whl; do
-    "${AUDITWHEEL}" show "$wheel" | tee /dev/stderr | grep \"manylinux1
+    "${AUDITWHEEL}" show "$wheel" | tee /dev/stderr |  grep -E -w "$AUDITWHEEL_PLAT"
     "${AUDITWHEEL}" repair "$wheel" -w "$ARTIFACT_DIR"
     rm "$wheel"
   done
   for wheel in tools/distrib/python/grpcio_tools/dist/*.whl; do
-    "${AUDITWHEEL}" show "$wheel" | tee /dev/stderr | grep \"manylinux1
+    "${AUDITWHEEL}" show "$wheel" | tee /dev/stderr |  grep -E -w "$AUDITWHEEL_PLAT"
     "${AUDITWHEEL}" repair "$wheel" -w "$ARTIFACT_DIR"
     rm "$wheel"
   done