diff --git a/templates/tools/dockerfile/python_deps.include b/templates/tools/dockerfile/python_deps.include
index ce36de8ad9c..c7bf238b5a9 100644
--- a/templates/tools/dockerfile/python_deps.include
+++ b/templates/tools/dockerfile/python_deps.include
@@ -9,6 +9,6 @@ RUN apt-get update && apt-get install -y ${'\\'}
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
diff --git a/templates/tools/dockerfile/test/cxx_alpine_x64/Dockerfile.template b/templates/tools/dockerfile/test/cxx_alpine_x64/Dockerfile.template
index b2505668615..d70ad946135 100644
--- a/templates/tools/dockerfile/test/cxx_alpine_x64/Dockerfile.template
+++ b/templates/tools/dockerfile/test/cxx_alpine_x64/Dockerfile.template
@@ -40,7 +40,7 @@
     zip
   
   # Install Python packages from PyPI
-  RUN pip install --upgrade pip==9.0.2
+  RUN pip install --upgrade pip==10.0.1
   RUN pip install virtualenv
   RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
   
diff --git a/tools/distrib/pylint_code.sh b/tools/distrib/pylint_code.sh
index 307fe6c0c0c..013b6660eb2 100755
--- a/tools/distrib/pylint_code.sh
+++ b/tools/distrib/pylint_code.sh
@@ -30,10 +30,11 @@ TEST_DIRS=(
 )
 
 VIRTUALENV=python_pylint_venv
+python -m virtualenv $VIRTUALENV
 
-virtualenv $VIRTUALENV
-PYTHON=$(realpath $VIRTUALENV/bin/python)
-$PYTHON -m pip install --upgrade pip==9.0.2
+PYTHON=$VIRTUALENV/bin/python
+
+$PYTHON -m pip install --upgrade pip==10.0.1
 $PYTHON -m pip install pylint==1.6.5
 
 for dir in "${DIRS[@]}"; do
diff --git a/tools/distrib/python/docgen.py b/tools/distrib/python/docgen.py
index 4d6fcb5d65d..732d948bbca 100755
--- a/tools/distrib/python/docgen.py
+++ b/tools/distrib/python/docgen.py
@@ -70,7 +70,7 @@ subprocess_arguments_list = [
         'env': environment
     },
     {
-        'args': [VIRTUALENV_PIP_PATH, 'install', '--upgrade', 'pip==9.0.1'],
+        'args': [VIRTUALENV_PIP_PATH, 'install', '--upgrade', 'pip==10.0.1'],
         'env': environment
     },
     {
diff --git a/tools/distrib/yapf_code.sh b/tools/distrib/yapf_code.sh
index 919e9c13d54..dbc842fa37a 100755
--- a/tools/distrib/yapf_code.sh
+++ b/tools/distrib/yapf_code.sh
@@ -32,7 +32,7 @@ VIRTUALENV=yapf_virtual_environment
 
 virtualenv $VIRTUALENV
 PYTHON=$(realpath "${VIRTUALENV}/bin/python")
-$PYTHON -m pip install --upgrade pip==9.0.2
+$PYTHON -m pip install --upgrade pip==10.0.1
 $PYTHON -m pip install --upgrade futures
 $PYTHON -m pip install yapf==0.20.0
 
diff --git a/tools/dockerfile/grpc_clang_tidy/Dockerfile b/tools/dockerfile/grpc_clang_tidy/Dockerfile
index d9599af45bb..dec7680fcf7 100644
--- a/tools/dockerfile/grpc_clang_tidy/Dockerfile
+++ b/tools/dockerfile/grpc_clang_tidy/Dockerfile
@@ -33,9 +33,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 ADD clang_tidy_all_the_things.sh /
 
diff --git a/tools/dockerfile/interoptest/grpc_interop_csharp/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_csharp/Dockerfile
index 96154c8d8fb..e806ba59237 100644
--- a/tools/dockerfile/interoptest/grpc_interop_csharp/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_csharp/Dockerfile
@@ -60,9 +60,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #================
 # C# dependencies
diff --git a/tools/dockerfile/interoptest/grpc_interop_csharpcoreclr/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_csharpcoreclr/Dockerfile
index 96154c8d8fb..e806ba59237 100644
--- a/tools/dockerfile/interoptest/grpc_interop_csharpcoreclr/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_csharpcoreclr/Dockerfile
@@ -60,9 +60,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #================
 # C# dependencies
diff --git a/tools/dockerfile/interoptest/grpc_interop_cxx/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_cxx/Dockerfile
index 3e0f477cc63..d3eb456e940 100644
--- a/tools/dockerfile/interoptest/grpc_interop_cxx/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_cxx/Dockerfile
@@ -60,9 +60,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/dockerfile/interoptest/grpc_interop_go/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_go/Dockerfile
index 83f05d87ea5..b136259ce90 100644
--- a/tools/dockerfile/interoptest/grpc_interop_go/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_go/Dockerfile
@@ -28,9 +28,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Define the default command.
 CMD ["bash"]
diff --git a/tools/dockerfile/interoptest/grpc_interop_go1.7/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_go1.7/Dockerfile
index 79907f3d7c3..d43d0e40f58 100644
--- a/tools/dockerfile/interoptest/grpc_interop_go1.7/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_go1.7/Dockerfile
@@ -28,9 +28,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Define the default command.
 CMD ["bash"]
diff --git a/tools/dockerfile/interoptest/grpc_interop_go1.8/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_go1.8/Dockerfile
index 42069419f85..17ca6784dae 100644
--- a/tools/dockerfile/interoptest/grpc_interop_go1.8/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_go1.8/Dockerfile
@@ -28,9 +28,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Define the default command.
 CMD ["bash"]
diff --git a/tools/dockerfile/interoptest/grpc_interop_http2/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_http2/Dockerfile
index c14bcdaa93e..e7555c95cf5 100644
--- a/tools/dockerfile/interoptest/grpc_interop_http2/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_http2/Dockerfile
@@ -28,9 +28,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 RUN pip install twisted h2==2.6.1 hyper
 
diff --git a/tools/dockerfile/interoptest/grpc_interop_java/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_java/Dockerfile
index 510e157d561..fc29ada0d2d 100644
--- a/tools/dockerfile/interoptest/grpc_interop_java/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_java/Dockerfile
@@ -43,9 +43,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 
 # Trigger download of as many Gradle artifacts as possible.
diff --git a/tools/dockerfile/interoptest/grpc_interop_java_oracle8/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_java_oracle8/Dockerfile
index 510e157d561..fc29ada0d2d 100644
--- a/tools/dockerfile/interoptest/grpc_interop_java_oracle8/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_java_oracle8/Dockerfile
@@ -43,9 +43,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 
 # Trigger download of as many Gradle artifacts as possible.
diff --git a/tools/dockerfile/interoptest/grpc_interop_node/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_node/Dockerfile
index 7464e31f0f9..539a869a7b5 100644
--- a/tools/dockerfile/interoptest/grpc_interop_node/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_node/Dockerfile
@@ -60,9 +60,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #==================
 # Node dependencies
diff --git a/tools/dockerfile/interoptest/grpc_interop_python/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_python/Dockerfile
index 49c1191ba9b..97cdf48db86 100644
--- a/tools/dockerfile/interoptest/grpc_interop_python/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_python/Dockerfile
@@ -60,9 +60,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Prepare ccache
 RUN ln -s /usr/bin/ccache /usr/local/bin/gcc
diff --git a/tools/dockerfile/interoptest/grpc_interop_ruby/Dockerfile b/tools/dockerfile/interoptest/grpc_interop_ruby/Dockerfile
index f3667b5ae05..75e3314e2be 100644
--- a/tools/dockerfile/interoptest/grpc_interop_ruby/Dockerfile
+++ b/tools/dockerfile/interoptest/grpc_interop_ruby/Dockerfile
@@ -60,9 +60,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #==================
 # Ruby dependencies
diff --git a/tools/dockerfile/test/csharp_jessie_x64/Dockerfile b/tools/dockerfile/test/csharp_jessie_x64/Dockerfile
index c9335f09419..7a8e26d2a72 100644
--- a/tools/dockerfile/test/csharp_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/csharp_jessie_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #================
 # C# dependencies
diff --git a/tools/dockerfile/test/cxx_alpine_x64/Dockerfile b/tools/dockerfile/test/cxx_alpine_x64/Dockerfile
index 5b2b527a81c..3449af1e203 100644
--- a/tools/dockerfile/test/cxx_alpine_x64/Dockerfile
+++ b/tools/dockerfile/test/cxx_alpine_x64/Dockerfile
@@ -38,7 +38,7 @@ RUN apk update && apk add \
   zip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
 RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
 
diff --git a/tools/dockerfile/test/cxx_jessie_x64/Dockerfile b/tools/dockerfile/test/cxx_jessie_x64/Dockerfile
index 825896b1a50..f2517539b67 100644
--- a/tools/dockerfile/test/cxx_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/cxx_jessie_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/dockerfile/test/cxx_jessie_x86/Dockerfile b/tools/dockerfile/test/cxx_jessie_x86/Dockerfile
index 692960dff76..bb9c7511e34 100644
--- a/tools/dockerfile/test/cxx_jessie_x86/Dockerfile
+++ b/tools/dockerfile/test/cxx_jessie_x86/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/dockerfile/test/cxx_ubuntu1404_x64/Dockerfile b/tools/dockerfile/test/cxx_ubuntu1404_x64/Dockerfile
index 38b040b2588..b0d9261af27 100644
--- a/tools/dockerfile/test/cxx_ubuntu1404_x64/Dockerfile
+++ b/tools/dockerfile/test/cxx_ubuntu1404_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/dockerfile/test/cxx_ubuntu1604_x64/Dockerfile b/tools/dockerfile/test/cxx_ubuntu1604_x64/Dockerfile
index 5487b6d28c4..65ff58e7289 100644
--- a/tools/dockerfile/test/cxx_ubuntu1604_x64/Dockerfile
+++ b/tools/dockerfile/test/cxx_ubuntu1604_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/dockerfile/test/cxx_ubuntu1710_x64/Dockerfile b/tools/dockerfile/test/cxx_ubuntu1710_x64/Dockerfile
index ffb08588cb6..e9264431346 100644
--- a/tools/dockerfile/test/cxx_ubuntu1710_x64/Dockerfile
+++ b/tools/dockerfile/test/cxx_ubuntu1710_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/dockerfile/test/fuzzer/Dockerfile b/tools/dockerfile/test/fuzzer/Dockerfile
index 36712191ec6..a2424923184 100644
--- a/tools/dockerfile/test/fuzzer/Dockerfile
+++ b/tools/dockerfile/test/fuzzer/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/dockerfile/test/multilang_jessie_x64/Dockerfile b/tools/dockerfile/test/multilang_jessie_x64/Dockerfile
index 8202a4a0605..962fe97de05 100644
--- a/tools/dockerfile/test/multilang_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/multilang_jessie_x64/Dockerfile
@@ -140,9 +140,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Install coverage for Python test coverage reporting
 RUN pip install coverage
diff --git a/tools/dockerfile/test/node_jessie_x64/Dockerfile b/tools/dockerfile/test/node_jessie_x64/Dockerfile
index e87eb6f63b4..f32b437b75e 100644
--- a/tools/dockerfile/test/node_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/node_jessie_x64/Dockerfile
@@ -75,9 +75,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #==================
 # Node dependencies
diff --git a/tools/dockerfile/test/php7_jessie_x64/Dockerfile b/tools/dockerfile/test/php7_jessie_x64/Dockerfile
index 3a638678672..e96be2769a4 100644
--- a/tools/dockerfile/test/php7_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/php7_jessie_x64/Dockerfile
@@ -75,9 +75,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Prepare ccache
 RUN ln -s /usr/bin/ccache /usr/local/bin/gcc
diff --git a/tools/dockerfile/test/php_jessie_x64/Dockerfile b/tools/dockerfile/test/php_jessie_x64/Dockerfile
index 32a4b61a400..88ee2677630 100644
--- a/tools/dockerfile/test/php_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/php_jessie_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # PHP dependencies
diff --git a/tools/dockerfile/test/python_alpine_x64/Dockerfile b/tools/dockerfile/test/python_alpine_x64/Dockerfile
index 66ec34ab59a..6e06e2d52c3 100644
--- a/tools/dockerfile/test/python_alpine_x64/Dockerfile
+++ b/tools/dockerfile/test/python_alpine_x64/Dockerfile
@@ -37,7 +37,7 @@ RUN apk update && apk add \
   zip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
 RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0
 
diff --git a/tools/dockerfile/test/python_jessie_x64/Dockerfile b/tools/dockerfile/test/python_jessie_x64/Dockerfile
index 4e6916d3c2c..41b670c06c6 100644
--- a/tools/dockerfile/test/python_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/python_jessie_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Prepare ccache
 RUN ln -s /usr/bin/ccache /usr/local/bin/gcc
diff --git a/tools/dockerfile/test/python_pyenv_x64/Dockerfile b/tools/dockerfile/test/python_pyenv_x64/Dockerfile
index bd1432eaf77..24fe7b2931d 100644
--- a/tools/dockerfile/test/python_pyenv_x64/Dockerfile
+++ b/tools/dockerfile/test/python_pyenv_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 # Install dependencies for pyenv
 RUN apt-get update && apt-get install -y \
diff --git a/tools/dockerfile/test/ruby_jessie_x64/Dockerfile b/tools/dockerfile/test/ruby_jessie_x64/Dockerfile
index 45923ca240d..37d909a038b 100644
--- a/tools/dockerfile/test/ruby_jessie_x64/Dockerfile
+++ b/tools/dockerfile/test/ruby_jessie_x64/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #==================
 # Ruby dependencies
diff --git a/tools/dockerfile/test/sanity/Dockerfile b/tools/dockerfile/test/sanity/Dockerfile
index c93693c6585..4885843aa4e 100644
--- a/tools/dockerfile/test/sanity/Dockerfile
+++ b/tools/dockerfile/test/sanity/Dockerfile
@@ -64,9 +64,9 @@ RUN apt-get update && apt-get install -y \
     python-pip
 
 # Install Python packages from PyPI
-RUN pip install --upgrade pip==9.0.2
+RUN pip install --upgrade pip==10.0.1
 RUN pip install virtualenv
-RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.0.post1 six==1.10.0 twisted==17.5.0
+RUN pip install futures==2.2.0 enum34==1.0.4 protobuf==3.5.2.post1 six==1.10.0 twisted==17.5.0
 
 #=================
 # C++ dependencies
diff --git a/tools/gce/linux_kokoro_performance_worker_init.sh b/tools/gce/linux_kokoro_performance_worker_init.sh
index 084e9fbff40..4a1e3e608b7 100755
--- a/tools/gce/linux_kokoro_performance_worker_init.sh
+++ b/tools/gce/linux_kokoro_performance_worker_init.sh
@@ -72,7 +72,7 @@ sudo apt-get install -y netperf
 sudo apt-get install -y libgflags-dev libgtest-dev libc++-dev clang
 
 # Python dependencies
-sudo pip install --upgrade pip==9.0.2
+sudo pip install --upgrade pip==10.0.1
 sudo pip install tabulate
 sudo pip install google-api-python-client
 sudo pip install virtualenv
diff --git a/tools/gce/linux_performance_worker_init.sh b/tools/gce/linux_performance_worker_init.sh
index 09d8fd012d1..7222cef9a2a 100755
--- a/tools/gce/linux_performance_worker_init.sh
+++ b/tools/gce/linux_performance_worker_init.sh
@@ -72,7 +72,7 @@ sudo apt-get install -y netperf
 sudo apt-get install -y libgflags-dev libgtest-dev libc++-dev clang
 
 # Python dependencies
-sudo pip install --upgrade pip==9.0.2
+sudo pip install --upgrade pip==10.0.1
 sudo pip install tabulate
 sudo pip install google-api-python-client
 sudo pip install virtualenv
diff --git a/tools/run_tests/helper_scripts/build_python.sh b/tools/run_tests/helper_scripts/build_python.sh
index bd952721adc..b0a6f0f4d4d 100755
--- a/tools/run_tests/helper_scripts/build_python.sh
+++ b/tools/run_tests/helper_scripts/build_python.sh
@@ -163,7 +163,7 @@ case "$VENV" in
   ;;
 esac
 
-$VENV_PYTHON -m pip install --upgrade pip==9.0.2
+$VENV_PYTHON -m pip install --upgrade pip==10.0.1
 $VENV_PYTHON -m pip install setuptools
 $VENV_PYTHON -m pip install cython
 $VENV_PYTHON -m pip install six enum34 protobuf futures