diff --git a/src/core/ext/xds/xds_endpoint.cc b/src/core/ext/xds/xds_endpoint.cc
index d9e703a767c..aee1544c24d 100644
--- a/src/core/ext/xds/xds_endpoint.cc
+++ b/src/core/ext/xds/xds_endpoint.cc
@@ -21,6 +21,7 @@
 #include <stdlib.h>
 
 #include <algorithm>
+#include <limits>
 #include <vector>
 
 #include "absl/status/status.h"
@@ -366,6 +367,19 @@ absl::StatusOr<XdsEndpointResource> EdsResourceParse(
       const auto& priority = eds_resource.priorities[i];
       if (priority.localities.empty()) {
         errors.AddError(absl::StrCat("priority ", i, " empty"));
+      } else {
+        // Check that the sum of the locality weights in this priority
+        // does not exceed the max value for a uint32.
+        uint64_t total_weight = 0;
+        for (const auto& p : priority.localities) {
+          total_weight += p.second.lb_weight;
+          if (total_weight > std::numeric_limits<uint32_t>::max()) {
+            errors.AddError(
+                absl::StrCat("sum of locality weights for priority ", i,
+                             " exceeds uint32 max"));
+            break;
+          }
+        }
       }
     }
   }
diff --git a/test/core/xds/xds_endpoint_resource_type_test.cc b/test/core/xds/xds_endpoint_resource_type_test.cc
index b3d8473ad9e..c60de87fb39 100644
--- a/test/core/xds/xds_endpoint_resource_type_test.cc
+++ b/test/core/xds/xds_endpoint_resource_type_test.cc
@@ -14,6 +14,9 @@
 // limitations under the License.
 //
 
+#include <stdint.h>
+
+#include <limits>
 #include <map>
 #include <memory>
 #include <string>
@@ -610,6 +613,45 @@ TEST_F(XdsEndpointTest, SparsePriorityList) {
       << decode_result.resource.status();
 }
 
+TEST_F(XdsEndpointTest, LocalityWeightsWithinPriorityExceedUint32Max) {
+  ClusterLoadAssignment cla;
+  cla.set_cluster_name("foo");
+  // First locality has weight of 1.
+  auto* locality = cla.add_endpoints();
+  locality->mutable_load_balancing_weight()->set_value(1);
+  auto* locality_name = locality->mutable_locality();
+  locality_name->set_region("myregion");
+  locality_name->set_zone("myzone");
+  locality_name->set_sub_zone("mysubzone");
+  auto* socket_address = locality->add_lb_endpoints()
+                             ->mutable_endpoint()
+                             ->mutable_address()
+                             ->mutable_socket_address();
+  socket_address->set_address("127.0.0.1");
+  socket_address->set_port_value(443);
+  locality->set_priority(0);
+  // Second locality has weight of uint32 max.
+  locality = cla.add_endpoints();
+  *locality = cla.endpoints(0);  // Copy first locality.
+  locality->mutable_locality()->set_region("myregion2");
+  locality->mutable_load_balancing_weight()->set_value(
+      std::numeric_limits<uint32_t>::max());
+  std::string serialized_resource;
+  ASSERT_TRUE(cla.SerializeToString(&serialized_resource));
+  auto* resource_type = XdsEndpointResourceType::Get();
+  auto decode_result = resource_type->Decode(
+      decode_context_, serialized_resource, /*is_v2=*/false);
+  ASSERT_TRUE(decode_result.name.has_value());
+  EXPECT_EQ(*decode_result.name, "foo");
+  EXPECT_EQ(decode_result.resource.status().code(),
+            absl::StatusCode::kInvalidArgument);
+  EXPECT_EQ(decode_result.resource.status().message(),
+            "errors parsing EDS resource: ["
+            "field:endpoints error:sum of locality weights for priority 0 "
+            "exceeds uint32 max]")
+      << decode_result.resource.status();
+}
+
 TEST_F(XdsEndpointTest, DropConfig) {
   ClusterLoadAssignment cla;
   cla.set_cluster_name("foo");