diff --git a/examples/python/helloworld/helloworld_pb2.py b/examples/python/helloworld/helloworld_pb2.py
index 6ee31ad94a2..f5b4f2d27dc 100644
--- a/examples/python/helloworld/helloworld_pb2.py
+++ b/examples/python/helloworld/helloworld_pb2.py
@@ -1,12 +1,11 @@
 # -*- coding: utf-8 -*-
 # Generated by the protocol buffer compiler.  DO NOT EDIT!
 # source: helloworld.proto
-# Protobuf Python Version: 4.25.0
 """Generated protocol buffer code."""
+from google.protobuf.internal import builder as _builder
 from google.protobuf import descriptor as _descriptor
 from google.protobuf import descriptor_pool as _descriptor_pool
 from google.protobuf import symbol_database as _symbol_database
-from google.protobuf.internal import builder as _builder
 # @@protoc_insertion_point(imports)
 
 _sym_db = _symbol_database.Default()
@@ -14,18 +13,18 @@ _sym_db = _symbol_database.Default()
 
 
 
-DESCRIPTOR = _descriptor_pool.Default().AddSerializedFile(b'\n\x10helloworld.proto\x12\nhelloworld\"\x1c\n\x0cHelloRequest\x12\x0c\n\x04name\x18\x01 \x01(\t\"\x1d\n\nHelloReply\x12\x0f\n\x07message\x18\x01 \x01(\t2\xe4\x01\n\x07Greeter\x12>\n\x08SayHello\x12\x18.helloworld.HelloRequest\x1a\x16.helloworld.HelloReply\"\x00\x12K\n\x13SayHelloStreamReply\x12\x18.helloworld.HelloRequest\x1a\x16.helloworld.HelloReply\"\x00\x30\x01\x12L\n\x12SayHelloBidiStream\x12\x18.helloworld.HelloRequest\x1a\x16.helloworld.HelloReply\"\x00(\x01\x30\x01\x42\x36\n\x1bio.grpc.examples.helloworldB\x0fHelloWorldProtoP\x01\xa2\x02\x03HLWb\x06proto3')
+DESCRIPTOR = _descriptor_pool.Default().AddSerializedFile(b'\n\x10helloworld.proto\x12\nhelloworld\"\x1c\n\x0cHelloRequest\x12\x0c\n\x04name\x18\x01 \x01(\t\"\x1d\n\nHelloReply\x12\x0f\n\x07message\x18\x01 \x01(\t2I\n\x07Greeter\x12>\n\x08SayHello\x12\x18.helloworld.HelloRequest\x1a\x16.helloworld.HelloReply\"\x00\x42\x36\n\x1bio.grpc.examples.helloworldB\x0fHelloWorldProtoP\x01\xa2\x02\x03HLWb\x06proto3')
 
-_globals = globals()
-_builder.BuildMessageAndEnumDescriptors(DESCRIPTOR, _globals)
-_builder.BuildTopDescriptorsAndMessages(DESCRIPTOR, 'helloworld_pb2', _globals)
+_builder.BuildMessageAndEnumDescriptors(DESCRIPTOR, globals())
+_builder.BuildTopDescriptorsAndMessages(DESCRIPTOR, 'helloworld_pb2', globals())
 if _descriptor._USE_C_DESCRIPTORS == False:
-  _globals['DESCRIPTOR']._options = None
-  _globals['DESCRIPTOR']._serialized_options = b'\n\033io.grpc.examples.helloworldB\017HelloWorldProtoP\001\242\002\003HLW'
-  _globals['_HELLOREQUEST']._serialized_start=32
-  _globals['_HELLOREQUEST']._serialized_end=60
-  _globals['_HELLOREPLY']._serialized_start=62
-  _globals['_HELLOREPLY']._serialized_end=91
-  _globals['_GREETER']._serialized_start=94
-  _globals['_GREETER']._serialized_end=322
+
+  DESCRIPTOR._options = None
+  DESCRIPTOR._serialized_options = b'\n\033io.grpc.examples.helloworldB\017HelloWorldProtoP\001\242\002\003HLW'
+  _HELLOREQUEST._serialized_start=32
+  _HELLOREQUEST._serialized_end=60
+  _HELLOREPLY._serialized_start=62
+  _HELLOREPLY._serialized_end=91
+  _GREETER._serialized_start=93
+  _GREETER._serialized_end=166
 # @@protoc_insertion_point(module_scope)
diff --git a/examples/python/helloworld/helloworld_pb2.pyi b/examples/python/helloworld/helloworld_pb2.pyi
index bf0bd395ad5..8c4b5b22805 100644
--- a/examples/python/helloworld/helloworld_pb2.pyi
+++ b/examples/python/helloworld/helloworld_pb2.pyi
@@ -4,14 +4,14 @@ from typing import ClassVar as _ClassVar, Optional as _Optional
 
 DESCRIPTOR: _descriptor.FileDescriptor
 
-class HelloRequest(_message.Message):
-    __slots__ = ("name",)
-    NAME_FIELD_NUMBER: _ClassVar[int]
-    name: str
-    def __init__(self, name: _Optional[str] = ...) -> None: ...
-
 class HelloReply(_message.Message):
-    __slots__ = ("message",)
+    __slots__ = ["message"]
     MESSAGE_FIELD_NUMBER: _ClassVar[int]
     message: str
     def __init__(self, message: _Optional[str] = ...) -> None: ...
+
+class HelloRequest(_message.Message):
+    __slots__ = ["name"]
+    NAME_FIELD_NUMBER: _ClassVar[int]
+    name: str
+    def __init__(self, name: _Optional[str] = ...) -> None: ...
diff --git a/examples/python/helloworld/helloworld_pb2_grpc.py b/examples/python/helloworld/helloworld_pb2_grpc.py
index 68bcfef1756..47c186976e1 100644
--- a/examples/python/helloworld/helloworld_pb2_grpc.py
+++ b/examples/python/helloworld/helloworld_pb2_grpc.py
@@ -19,17 +19,7 @@ class GreeterStub(object):
                 '/helloworld.Greeter/SayHello',
                 request_serializer=helloworld__pb2.HelloRequest.SerializeToString,
                 response_deserializer=helloworld__pb2.HelloReply.FromString,
-                _registered_method=True)
-        self.SayHelloStreamReply = channel.unary_stream(
-                '/helloworld.Greeter/SayHelloStreamReply',
-                request_serializer=helloworld__pb2.HelloRequest.SerializeToString,
-                response_deserializer=helloworld__pb2.HelloReply.FromString,
-                _registered_method=True)
-        self.SayHelloBidiStream = channel.stream_stream(
-                '/helloworld.Greeter/SayHelloBidiStream',
-                request_serializer=helloworld__pb2.HelloRequest.SerializeToString,
-                response_deserializer=helloworld__pb2.HelloReply.FromString,
-                _registered_method=True)
+                )
 
 
 class GreeterServicer(object):
@@ -43,18 +33,6 @@ class GreeterServicer(object):
         context.set_details('Method not implemented!')
         raise NotImplementedError('Method not implemented!')
 
-    def SayHelloStreamReply(self, request, context):
-        """Missing associated documentation comment in .proto file."""
-        context.set_code(grpc.StatusCode.UNIMPLEMENTED)
-        context.set_details('Method not implemented!')
-        raise NotImplementedError('Method not implemented!')
-
-    def SayHelloBidiStream(self, request_iterator, context):
-        """Missing associated documentation comment in .proto file."""
-        context.set_code(grpc.StatusCode.UNIMPLEMENTED)
-        context.set_details('Method not implemented!')
-        raise NotImplementedError('Method not implemented!')
-
 
 def add_GreeterServicer_to_server(servicer, server):
     rpc_method_handlers = {
@@ -63,16 +41,6 @@ def add_GreeterServicer_to_server(servicer, server):
                     request_deserializer=helloworld__pb2.HelloRequest.FromString,
                     response_serializer=helloworld__pb2.HelloReply.SerializeToString,
             ),
-            'SayHelloStreamReply': grpc.unary_stream_rpc_method_handler(
-                    servicer.SayHelloStreamReply,
-                    request_deserializer=helloworld__pb2.HelloRequest.FromString,
-                    response_serializer=helloworld__pb2.HelloReply.SerializeToString,
-            ),
-            'SayHelloBidiStream': grpc.stream_stream_rpc_method_handler(
-                    servicer.SayHelloBidiStream,
-                    request_deserializer=helloworld__pb2.HelloRequest.FromString,
-                    response_serializer=helloworld__pb2.HelloReply.SerializeToString,
-            ),
     }
     generic_handler = grpc.method_handlers_generic_handler(
             'helloworld.Greeter', rpc_method_handlers)
@@ -95,72 +63,8 @@ class Greeter(object):
             wait_for_ready=None,
             timeout=None,
             metadata=None):
-        return grpc.experimental.unary_unary(
-            request,
-            target,
-            '/helloworld.Greeter/SayHello',
-            helloworld__pb2.HelloRequest.SerializeToString,
-            helloworld__pb2.HelloReply.FromString,
-            options,
-            channel_credentials,
-            insecure,
-            call_credentials,
-            compression,
-            wait_for_ready,
-            timeout,
-            metadata,
-            _registered_method=True)
-
-    @staticmethod
-    def SayHelloStreamReply(request,
-            target,
-            options=(),
-            channel_credentials=None,
-            call_credentials=None,
-            insecure=False,
-            compression=None,
-            wait_for_ready=None,
-            timeout=None,
-            metadata=None):
-        return grpc.experimental.unary_stream(
-            request,
-            target,
-            '/helloworld.Greeter/SayHelloStreamReply',
-            helloworld__pb2.HelloRequest.SerializeToString,
-            helloworld__pb2.HelloReply.FromString,
-            options,
-            channel_credentials,
-            insecure,
-            call_credentials,
-            compression,
-            wait_for_ready,
-            timeout,
-            metadata,
-            _registered_method=True)
-
-    @staticmethod
-    def SayHelloBidiStream(request_iterator,
-            target,
-            options=(),
-            channel_credentials=None,
-            call_credentials=None,
-            insecure=False,
-            compression=None,
-            wait_for_ready=None,
-            timeout=None,
-            metadata=None):
-        return grpc.experimental.stream_stream(
-            request_iterator,
-            target,
-            '/helloworld.Greeter/SayHelloBidiStream',
+        return grpc.experimental.unary_unary(request, target, '/helloworld.Greeter/SayHello',
             helloworld__pb2.HelloRequest.SerializeToString,
             helloworld__pb2.HelloReply.FromString,
-            options,
-            channel_credentials,
-            insecure,
-            call_credentials,
-            compression,
-            wait_for_ready,
-            timeout,
-            metadata,
-            _registered_method=True)
+            options, channel_credentials,
+            insecure, call_credentials, compression, wait_for_ready, timeout, metadata)
diff --git a/src/compiler/python_generator.cc b/src/compiler/python_generator.cc
index b7a3115bce0..753fe1c8887 100644
--- a/src/compiler/python_generator.cc
+++ b/src/compiler/python_generator.cc
@@ -467,7 +467,7 @@ bool PrivateGenerator::PrintStub(
           out->Print(
               method_dict,
               "response_deserializer=$ResponseModuleAndClass$.FromString,\n");
-          out->Print("_registered_method=True)\n");
+          out->Print(")\n");
         }
       }
     }
@@ -642,27 +642,22 @@ bool PrivateGenerator::PrintServiceClass(
         args_dict["ArityMethodName"] = arity_method_name;
         args_dict["PackageQualifiedService"] = package_qualified_service_name;
         args_dict["Method"] = method->name();
-        out->Print(args_dict, "return grpc.experimental.$ArityMethodName$(\n");
+        out->Print(args_dict,
+                   "return "
+                   "grpc.experimental.$ArityMethodName$($RequestParameter$, "
+                   "target, '/$PackageQualifiedService$/$Method$',\n");
         {
           IndentScope continuation_indent(out);
           StringMap serializer_dict;
-          out->Print(args_dict, "$RequestParameter$,\n");
-          out->Print("target,\n");
-          out->Print(args_dict, "'/$PackageQualifiedService$/$Method$',\n");
           serializer_dict["RequestModuleAndClass"] = request_module_and_class;
           serializer_dict["ResponseModuleAndClass"] = response_module_and_class;
           out->Print(serializer_dict,
                      "$RequestModuleAndClass$.SerializeToString,\n");
           out->Print(serializer_dict, "$ResponseModuleAndClass$.FromString,\n");
-          out->Print("options,\n");
-          out->Print("channel_credentials,\n");
-          out->Print("insecure,\n");
-          out->Print("call_credentials,\n");
-          out->Print("compression,\n");
-          out->Print("wait_for_ready,\n");
-          out->Print("timeout,\n");
-          out->Print("metadata,\n");
-          out->Print("_registered_method=True)\n");
+          out->Print("options, channel_credentials,\n");
+          out->Print(
+              "insecure, call_credentials, compression, wait_for_ready, "
+              "timeout, metadata)\n");
         }
       }
     }
diff --git a/src/python/.gitignore b/src/python/.gitignore
index 61363e8cb8d..095ab8bbae1 100644
--- a/src/python/.gitignore
+++ b/src/python/.gitignore
@@ -1,6 +1,4 @@
-build/
-grpc_root/
-third_party/
+gens/
 *_pb2.py
 *_pb2.pyi
 *_pb2_grpc.py
diff --git a/src/python/grpcio/grpc/__init__.py b/src/python/grpcio/grpc/__init__.py
index e0ec581f9d4..83ded1b5df8 100644
--- a/src/python/grpcio/grpc/__init__.py
+++ b/src/python/grpcio/grpc/__init__.py
@@ -1004,7 +1004,6 @@ class Channel(abc.ABC):
         method,
         request_serializer=None,
         response_deserializer=None,
-        _registered_method=False,
     ):
         """Creates a UnaryUnaryMultiCallable for a unary-unary method.
 
@@ -1015,8 +1014,6 @@ class Channel(abc.ABC):
           response_deserializer: Optional :term:`deserializer` for deserializing the
             response message. Response goes undeserialized in case None
             is passed.
-          _registered_method: Implementation Private. A bool representing whether the method
-            is registered.
 
         Returns:
           A UnaryUnaryMultiCallable value for the named unary-unary method.
@@ -1029,7 +1026,6 @@ class Channel(abc.ABC):
         method,
         request_serializer=None,
         response_deserializer=None,
-        _registered_method=False,
     ):
         """Creates a UnaryStreamMultiCallable for a unary-stream method.
 
@@ -1040,8 +1036,6 @@ class Channel(abc.ABC):
           response_deserializer: Optional :term:`deserializer` for deserializing the
             response message. Response goes undeserialized in case None is
             passed.
-          _registered_method: Implementation Private. A bool representing whether the method
-            is registered.
 
         Returns:
           A UnaryStreamMultiCallable value for the name unary-stream method.
@@ -1054,7 +1048,6 @@ class Channel(abc.ABC):
         method,
         request_serializer=None,
         response_deserializer=None,
-        _registered_method=False,
     ):
         """Creates a StreamUnaryMultiCallable for a stream-unary method.
 
@@ -1065,8 +1058,6 @@ class Channel(abc.ABC):
           response_deserializer: Optional :term:`deserializer` for deserializing the
             response message. Response goes undeserialized in case None is
             passed.
-          _registered_method: Implementation Private. A bool representing whether the method
-            is registered.
 
         Returns:
           A StreamUnaryMultiCallable value for the named stream-unary method.
@@ -1079,7 +1070,6 @@ class Channel(abc.ABC):
         method,
         request_serializer=None,
         response_deserializer=None,
-        _registered_method=False,
     ):
         """Creates a StreamStreamMultiCallable for a stream-stream method.
 
@@ -1090,8 +1080,6 @@ class Channel(abc.ABC):
           response_deserializer: Optional :term:`deserializer` for deserializing the
             response message. Response goes undeserialized in case None
             is passed.
-          _registered_method: Implementation Private. A bool representing whether the method
-            is registered.
 
         Returns:
           A StreamStreamMultiCallable value for the named stream-stream method.
diff --git a/src/python/grpcio/grpc/_channel.py b/src/python/grpcio/grpc/_channel.py
index bf29982ca65..79c85a1b94c 100644
--- a/src/python/grpcio/grpc/_channel.py
+++ b/src/python/grpcio/grpc/_channel.py
@@ -24,7 +24,6 @@ import types
 from typing import (
     Any,
     Callable,
-    Dict,
     Iterator,
     List,
     Optional,
@@ -1055,7 +1054,6 @@ class _UnaryUnaryMultiCallable(grpc.UnaryUnaryMultiCallable):
     _request_serializer: Optional[SerializingFunction]
     _response_deserializer: Optional[DeserializingFunction]
     _context: Any
-    _registered_call_handle: Optional[int]
 
     __slots__ = [
         "_channel",
@@ -1076,7 +1074,6 @@ class _UnaryUnaryMultiCallable(grpc.UnaryUnaryMultiCallable):
         target: bytes,
         request_serializer: Optional[SerializingFunction],
         response_deserializer: Optional[DeserializingFunction],
-        _registered_call_handle: Optional[int],
     ):
         self._channel = channel
         self._managed_call = managed_call
@@ -1085,7 +1082,6 @@ class _UnaryUnaryMultiCallable(grpc.UnaryUnaryMultiCallable):
         self._request_serializer = request_serializer
         self._response_deserializer = response_deserializer
         self._context = cygrpc.build_census_context()
-        self._registered_call_handle = _registered_call_handle
 
     def _prepare(
         self,
@@ -1157,7 +1153,6 @@ class _UnaryUnaryMultiCallable(grpc.UnaryUnaryMultiCallable):
                     ),
                 ),
                 self._context,
-                self._registered_call_handle,
             )
             event = call.next_event()
             _handle_event(event, state, self._response_deserializer)
@@ -1226,7 +1221,6 @@ class _UnaryUnaryMultiCallable(grpc.UnaryUnaryMultiCallable):
                 (operations,),
                 event_handler,
                 self._context,
-                self._registered_call_handle,
             )
             return _MultiThreadedRendezvous(
                 state, call, self._response_deserializer, deadline
@@ -1240,7 +1234,6 @@ class _SingleThreadedUnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
     _request_serializer: Optional[SerializingFunction]
     _response_deserializer: Optional[DeserializingFunction]
     _context: Any
-    _registered_call_handle: Optional[int]
 
     __slots__ = [
         "_channel",
@@ -1259,7 +1252,6 @@ class _SingleThreadedUnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
         target: bytes,
         request_serializer: SerializingFunction,
         response_deserializer: DeserializingFunction,
-        _registered_call_handle: Optional[int],
     ):
         self._channel = channel
         self._method = method
@@ -1267,7 +1259,6 @@ class _SingleThreadedUnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
         self._request_serializer = request_serializer
         self._response_deserializer = response_deserializer
         self._context = cygrpc.build_census_context()
-        self._registered_call_handle = _registered_call_handle
 
     def __call__(  # pylint: disable=too-many-locals
         self,
@@ -1326,7 +1317,6 @@ class _SingleThreadedUnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
             call_credentials,
             operations_and_tags,
             self._context,
-            self._registered_call_handle,
         )
         return _SingleThreadedRendezvous(
             state, call, self._response_deserializer, deadline
@@ -1341,7 +1331,6 @@ class _UnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
     _request_serializer: Optional[SerializingFunction]
     _response_deserializer: Optional[DeserializingFunction]
     _context: Any
-    _registered_call_handle: Optional[int]
 
     __slots__ = [
         "_channel",
@@ -1362,7 +1351,6 @@ class _UnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
         target: bytes,
         request_serializer: SerializingFunction,
         response_deserializer: DeserializingFunction,
-        _registered_call_handle: Optional[int],
     ):
         self._channel = channel
         self._managed_call = managed_call
@@ -1371,7 +1359,6 @@ class _UnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
         self._request_serializer = request_serializer
         self._response_deserializer = response_deserializer
         self._context = cygrpc.build_census_context()
-        self._registered_call_handle = _registered_call_handle
 
     def __call__(  # pylint: disable=too-many-locals
         self,
@@ -1421,7 +1408,6 @@ class _UnaryStreamMultiCallable(grpc.UnaryStreamMultiCallable):
                 operations,
                 _event_handler(state, self._response_deserializer),
                 self._context,
-                self._registered_call_handle,
             )
             return _MultiThreadedRendezvous(
                 state, call, self._response_deserializer, deadline
@@ -1436,7 +1422,6 @@ class _StreamUnaryMultiCallable(grpc.StreamUnaryMultiCallable):
     _request_serializer: Optional[SerializingFunction]
     _response_deserializer: Optional[DeserializingFunction]
     _context: Any
-    _registered_call_handle: Optional[int]
 
     __slots__ = [
         "_channel",
@@ -1457,7 +1442,6 @@ class _StreamUnaryMultiCallable(grpc.StreamUnaryMultiCallable):
         target: bytes,
         request_serializer: Optional[SerializingFunction],
         response_deserializer: Optional[DeserializingFunction],
-        _registered_call_handle: Optional[int],
     ):
         self._channel = channel
         self._managed_call = managed_call
@@ -1466,7 +1450,6 @@ class _StreamUnaryMultiCallable(grpc.StreamUnaryMultiCallable):
         self._request_serializer = request_serializer
         self._response_deserializer = response_deserializer
         self._context = cygrpc.build_census_context()
-        self._registered_call_handle = _registered_call_handle
 
     def _blocking(
         self,
@@ -1499,7 +1482,6 @@ class _StreamUnaryMultiCallable(grpc.StreamUnaryMultiCallable):
                 augmented_metadata, initial_metadata_flags
             ),
             self._context,
-            self._registered_call_handle,
         )
         _consume_request_iterator(
             request_iterator, state, call, self._request_serializer, None
@@ -1590,7 +1572,6 @@ class _StreamUnaryMultiCallable(grpc.StreamUnaryMultiCallable):
             ),
             event_handler,
             self._context,
-            self._registered_call_handle,
         )
         _consume_request_iterator(
             request_iterator,
@@ -1612,7 +1593,6 @@ class _StreamStreamMultiCallable(grpc.StreamStreamMultiCallable):
     _request_serializer: Optional[SerializingFunction]
     _response_deserializer: Optional[DeserializingFunction]
     _context: Any
-    _registered_call_handle: Optional[int]
 
     __slots__ = [
         "_channel",
@@ -1631,9 +1611,8 @@ class _StreamStreamMultiCallable(grpc.StreamStreamMultiCallable):
         managed_call: IntegratedCallFactory,
         method: bytes,
         target: bytes,
-        request_serializer: Optional[SerializingFunction],
-        response_deserializer: Optional[DeserializingFunction],
-        _registered_call_handle: Optional[int],
+        request_serializer: Optional[SerializingFunction] = None,
+        response_deserializer: Optional[DeserializingFunction] = None,
     ):
         self._channel = channel
         self._managed_call = managed_call
@@ -1642,7 +1621,6 @@ class _StreamStreamMultiCallable(grpc.StreamStreamMultiCallable):
         self._request_serializer = request_serializer
         self._response_deserializer = response_deserializer
         self._context = cygrpc.build_census_context()
-        self._registered_call_handle = _registered_call_handle
 
     def __call__(
         self,
@@ -1684,7 +1662,6 @@ class _StreamStreamMultiCallable(grpc.StreamStreamMultiCallable):
             operations,
             event_handler,
             self._context,
-            self._registered_call_handle,
         )
         _consume_request_iterator(
             request_iterator,
@@ -1774,8 +1751,7 @@ def _channel_managed_call_management(state: _ChannelCallState):
         credentials: Optional[cygrpc.CallCredentials],
         operations: Sequence[Sequence[cygrpc.Operation]],
         event_handler: UserTag,
-        context: Any,
-        _registered_call_handle: Optional[int],
+        context,
     ) -> cygrpc.IntegratedCall:
         """Creates a cygrpc.IntegratedCall.
 
@@ -1792,8 +1768,6 @@ def _channel_managed_call_management(state: _ChannelCallState):
           event_handler: A behavior to call to handle the events resultant from
             the operations on the call.
           context: Context object for distributed tracing.
-          _registered_call_handle: An int representing the call handle of the
-            method, or None if the method is not registered.
         Returns:
           A cygrpc.IntegratedCall with which to conduct an RPC.
         """
@@ -1814,7 +1788,6 @@ def _channel_managed_call_management(state: _ChannelCallState):
                 credentials,
                 operations_and_tags,
                 context,
-                _registered_call_handle,
             )
             if state.managed_calls == 0:
                 state.managed_calls = 1
@@ -2048,7 +2021,6 @@ class Channel(grpc.Channel):
     _call_state: _ChannelCallState
     _connectivity_state: _ChannelConnectivityState
     _target: str
-    _registered_call_handles: Dict[str, int]
 
     def __init__(
         self,
@@ -2083,22 +2055,6 @@ class Channel(grpc.Channel):
         if cygrpc.g_gevent_activated:
             cygrpc.gevent_increment_channel_count()
 
-    def _get_registered_call_handle(self, method: str) -> int:
-        """
-        Get the registered call handle for a method.
-
-        This is a semi-private method. It is intended for use only by gRPC generated code.
-
-        This method is not thread-safe.
-
-        Args:
-          method: Required, the method name for the RPC.
-
-        Returns:
-          The registered call handle pointer in the form of a Python Long.
-        """
-        return self._channel.get_registered_call_handle(_common.encode(method))
-
     def _process_python_options(
         self, python_options: Sequence[ChannelArgumentType]
     ) -> None:
@@ -2122,17 +2078,12 @@ class Channel(grpc.Channel):
     ) -> None:
         _unsubscribe(self._connectivity_state, callback)
 
-    # pylint: disable=arguments-differ
     def unary_unary(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.UnaryUnaryMultiCallable:
-        _registered_call_handle = None
-        if _registered_method:
-            _registered_call_handle = self._get_registered_call_handle(method)
         return _UnaryUnaryMultiCallable(
             self._channel,
             _channel_managed_call_management(self._call_state),
@@ -2140,20 +2091,14 @@ class Channel(grpc.Channel):
             _common.encode(self._target),
             request_serializer,
             response_deserializer,
-            _registered_call_handle,
         )
 
-    # pylint: disable=arguments-differ
     def unary_stream(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.UnaryStreamMultiCallable:
-        _registered_call_handle = None
-        if _registered_method:
-            _registered_call_handle = self._get_registered_call_handle(method)
         # NOTE(rbellevi): Benchmarks have shown that running a unary-stream RPC
         # on a single Python thread results in an appreciable speed-up. However,
         # due to slight differences in capability, the multi-threaded variant
@@ -2165,7 +2110,6 @@ class Channel(grpc.Channel):
                 _common.encode(self._target),
                 request_serializer,
                 response_deserializer,
-                _registered_call_handle,
             )
         else:
             return _UnaryStreamMultiCallable(
@@ -2175,20 +2119,14 @@ class Channel(grpc.Channel):
                 _common.encode(self._target),
                 request_serializer,
                 response_deserializer,
-                _registered_call_handle,
             )
 
-    # pylint: disable=arguments-differ
     def stream_unary(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.StreamUnaryMultiCallable:
-        _registered_call_handle = None
-        if _registered_method:
-            _registered_call_handle = self._get_registered_call_handle(method)
         return _StreamUnaryMultiCallable(
             self._channel,
             _channel_managed_call_management(self._call_state),
@@ -2196,20 +2134,14 @@ class Channel(grpc.Channel):
             _common.encode(self._target),
             request_serializer,
             response_deserializer,
-            _registered_call_handle,
         )
 
-    # pylint: disable=arguments-differ
     def stream_stream(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.StreamStreamMultiCallable:
-        _registered_call_handle = None
-        if _registered_method:
-            _registered_call_handle = self._get_registered_call_handle(method)
         return _StreamStreamMultiCallable(
             self._channel,
             _channel_managed_call_management(self._call_state),
@@ -2217,7 +2149,6 @@ class Channel(grpc.Channel):
             _common.encode(self._target),
             request_serializer,
             response_deserializer,
-            _registered_call_handle,
         )
 
     def _unsubscribe_all(self) -> None:
diff --git a/src/python/grpcio/grpc/_cython/_cygrpc/channel.pxd.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/channel.pxd.pxi
index 96d03e181b9..6e5416a9e31 100644
--- a/src/python/grpcio/grpc/_cython/_cygrpc/channel.pxd.pxi
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/channel.pxd.pxi
@@ -74,13 +74,6 @@ cdef class SegregatedCall:
 cdef class Channel:
 
   cdef _ChannelState _state
-  cdef dict _registered_call_handles
 
   # TODO(https://github.com/grpc/grpc/issues/15662): Eliminate this.
   cdef tuple _arguments
-
-
-cdef class CallHandle:
-
-  cdef void *c_call_handle
-  cdef object method
diff --git a/src/python/grpcio/grpc/_cython/_cygrpc/channel.pyx.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/channel.pyx.pxi
index dde3b166789..f6db36ebde1 100644
--- a/src/python/grpcio/grpc/_cython/_cygrpc/channel.pyx.pxi
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/channel.pyx.pxi
@@ -101,25 +101,6 @@ cdef class _ChannelState:
     self.connectivity_due = set()
     self.closed_reason = None
 
-cdef class CallHandle:
-
-  def __cinit__(self, _ChannelState channel_state, object method):
-    self.method = method
-    cpython.Py_INCREF(method)
-    # Note that since we always pass None for host, we set the
-    # second-to-last parameter of grpc_channel_register_call to a fixed
-    # NULL value.
-    self.c_call_handle = grpc_channel_register_call(
-      channel_state.c_channel, <const char *>method, NULL, NULL)
-
-  def __dealloc__(self):
-    cpython.Py_DECREF(self.method)
-
-  @property
-  def call_handle(self):
-    return cpython.PyLong_FromVoidPtr(self.c_call_handle)
-
-
 
 cdef tuple _operate(grpc_call *c_call, object operations, object user_tag):
   cdef grpc_call_error c_call_error
@@ -218,7 +199,7 @@ cdef void _call(
     grpc_completion_queue *c_completion_queue, on_success, int flags, method,
     host, object deadline, CallCredentials credentials,
     object operationses_and_user_tags, object metadata,
-    object context, object registered_call_handle) except *:
+    object context) except *:
   """Invokes an RPC.
 
   Args:
@@ -245,8 +226,6 @@ cdef void _call(
       must be present in the first element of this value.
     metadata: The metadata for this call.
     context: Context object for distributed tracing.
-    registered_call_handle: An int representing the call handle of the method, or
-      None if the method is not registered.
   """
   cdef grpc_slice method_slice
   cdef grpc_slice host_slice
@@ -263,16 +242,10 @@ cdef void _call(
       else:
         host_slice = _slice_from_bytes(host)
         host_slice_ptr = &host_slice
-      if registered_call_handle:
-        call_state.c_call = grpc_channel_create_registered_call(
-            channel_state.c_channel, NULL, flags,
-            c_completion_queue, cpython.PyLong_AsVoidPtr(registered_call_handle),
-            _timespec_from_time(deadline), NULL)
-      else:
-        call_state.c_call = grpc_channel_create_call(
-            channel_state.c_channel, NULL, flags,
-            c_completion_queue, method_slice, host_slice_ptr,
-            _timespec_from_time(deadline), NULL)
+      call_state.c_call = grpc_channel_create_call(
+          channel_state.c_channel, NULL, flags,
+          c_completion_queue, method_slice, host_slice_ptr,
+          _timespec_from_time(deadline), NULL)
       grpc_slice_unref(method_slice)
       if host_slice_ptr:
         grpc_slice_unref(host_slice)
@@ -336,7 +309,7 @@ cdef class IntegratedCall:
 cdef IntegratedCall _integrated_call(
     _ChannelState state, int flags, method, host, object deadline,
     object metadata, CallCredentials credentials, operationses_and_user_tags,
-    object context, object registered_call_handle):
+    object context):
   call_state = _CallState()
 
   def on_success(started_tags):
@@ -345,8 +318,7 @@ cdef IntegratedCall _integrated_call(
 
   _call(
       state, call_state, state.c_call_completion_queue, on_success, flags,
-      method, host, deadline, credentials, operationses_and_user_tags,
-      metadata, context, registered_call_handle)
+      method, host, deadline, credentials, operationses_and_user_tags, metadata, context)
 
   return IntegratedCall(state, call_state)
 
@@ -399,7 +371,7 @@ cdef class SegregatedCall:
 cdef SegregatedCall _segregated_call(
     _ChannelState state, int flags, method, host, object deadline,
     object metadata, CallCredentials credentials, operationses_and_user_tags,
-    object context, object registered_call_handle):
+    object context):
   cdef _CallState call_state = _CallState()
   cdef SegregatedCall segregated_call
   cdef grpc_completion_queue *c_completion_queue
@@ -417,7 +389,7 @@ cdef SegregatedCall _segregated_call(
     _call(
         state, call_state, c_completion_queue, on_success, flags, method, host,
         deadline, credentials, operationses_and_user_tags, metadata,
-        context, registered_call_handle)
+        context)
   except:
     _destroy_c_completion_queue(c_completion_queue)
     raise
@@ -514,7 +486,6 @@ cdef class Channel:
         else grpc_insecure_credentials_create())
     self._state.c_channel = grpc_channel_create(
         <char *>target, c_channel_credentials, channel_args.c_args())
-    self._registered_call_handles = {}
     grpc_channel_credentials_release(c_channel_credentials)
 
   def target(self):
@@ -528,10 +499,10 @@ cdef class Channel:
   def integrated_call(
       self, int flags, method, host, object deadline, object metadata,
       CallCredentials credentials, operationses_and_tags,
-      object context = None, object registered_call_handle = None):
+      object context = None):
     return _integrated_call(
         self._state, flags, method, host, deadline, metadata, credentials,
-        operationses_and_tags, context, registered_call_handle)
+        operationses_and_tags, context)
 
   def next_call_event(self):
     def on_success(tag):
@@ -550,10 +521,10 @@ cdef class Channel:
   def segregated_call(
       self, int flags, method, host, object deadline, object metadata,
       CallCredentials credentials, operationses_and_tags,
-      object context = None, object registered_call_handle = None):
+      object context = None):
     return _segregated_call(
         self._state, flags, method, host, deadline, metadata, credentials,
-        operationses_and_tags, context, registered_call_handle)
+        operationses_and_tags, context)
 
   def check_connectivity_state(self, bint try_to_connect):
     with self._state.condition:
@@ -572,19 +543,3 @@ cdef class Channel:
 
   def close_on_fork(self, code, details):
     _close(self, code, details, True)
-
-  def get_registered_call_handle(self, method):
-    """
-    Get or registers a call handler for a method.
-
-    This method is not thread-safe.
-
-    Args:
-      method: Required, the method name for the RPC.
-
-    Returns:
-      The registered call handle pointer in the form of a Python Long. 
-    """
-    if method not in self._registered_call_handles.keys():
-      self._registered_call_handles[method] = CallHandle(self._state, method)
-    return self._registered_call_handles[method].call_handle
diff --git a/src/python/grpcio/grpc/_cython/_cygrpc/grpc.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/grpc.pxi
index 29149e9893a..e1bc87d4abd 100644
--- a/src/python/grpcio/grpc/_cython/_cygrpc/grpc.pxi
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/grpc.pxi
@@ -433,12 +433,6 @@ cdef extern from "grpc/grpc.h":
     grpc_channel *channel, grpc_call *parent_call, uint32_t propagation_mask,
     grpc_completion_queue *completion_queue, grpc_slice method,
     const grpc_slice *host, gpr_timespec deadline, void *reserved) nogil
-  void *grpc_channel_register_call(
-    grpc_channel *channel, const char *method, const char *host, void *reserved) nogil
-  grpc_call *grpc_channel_create_registered_call(
-    grpc_channel *channel, grpc_call *parent_call, uint32_t propagation_mask,
-    grpc_completion_queue *completion_queue, void* registered_call_handle,
-    gpr_timespec deadline, void *reserved) nogil
   grpc_connectivity_state grpc_channel_check_connectivity_state(
       grpc_channel *channel, int try_to_connect) nogil
   void grpc_channel_watch_connectivity_state(
diff --git a/src/python/grpcio/grpc/_interceptor.py b/src/python/grpcio/grpc/_interceptor.py
index 94abafebaa6..36bce4e3ba5 100644
--- a/src/python/grpcio/grpc/_interceptor.py
+++ b/src/python/grpcio/grpc/_interceptor.py
@@ -684,85 +684,57 @@ class _Channel(grpc.Channel):
     def unsubscribe(self, callback: Callable):
         self._channel.unsubscribe(callback)
 
-    # pylint: disable=arguments-differ
     def unary_unary(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.UnaryUnaryMultiCallable:
-        # pytype: disable=wrong-arg-count
         thunk = lambda m: self._channel.unary_unary(
-            m,
-            request_serializer,
-            response_deserializer,
-            _registered_method,
+            m, request_serializer, response_deserializer
         )
-        # pytype: enable=wrong-arg-count
         if isinstance(self._interceptor, grpc.UnaryUnaryClientInterceptor):
             return _UnaryUnaryMultiCallable(thunk, method, self._interceptor)
         else:
             return thunk(method)
 
-    # pylint: disable=arguments-differ
     def unary_stream(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.UnaryStreamMultiCallable:
-        # pytype: disable=wrong-arg-count
         thunk = lambda m: self._channel.unary_stream(
-            m,
-            request_serializer,
-            response_deserializer,
-            _registered_method,
+            m, request_serializer, response_deserializer
         )
-        # pytype: enable=wrong-arg-count
         if isinstance(self._interceptor, grpc.UnaryStreamClientInterceptor):
             return _UnaryStreamMultiCallable(thunk, method, self._interceptor)
         else:
             return thunk(method)
 
-    # pylint: disable=arguments-differ
     def stream_unary(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.StreamUnaryMultiCallable:
-        # pytype: disable=wrong-arg-count
         thunk = lambda m: self._channel.stream_unary(
-            m,
-            request_serializer,
-            response_deserializer,
-            _registered_method,
+            m, request_serializer, response_deserializer
         )
-        # pytype: enable=wrong-arg-count
         if isinstance(self._interceptor, grpc.StreamUnaryClientInterceptor):
             return _StreamUnaryMultiCallable(thunk, method, self._interceptor)
         else:
             return thunk(method)
 
-    # pylint: disable=arguments-differ
     def stream_stream(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> grpc.StreamStreamMultiCallable:
-        # pytype: disable=wrong-arg-count
         thunk = lambda m: self._channel.stream_stream(
-            m,
-            request_serializer,
-            response_deserializer,
-            _registered_method,
+            m, request_serializer, response_deserializer
         )
-        # pytype: enable=wrong-arg-count
         if isinstance(self._interceptor, grpc.StreamStreamClientInterceptor):
             return _StreamStreamMultiCallable(thunk, method, self._interceptor)
         else:
diff --git a/src/python/grpcio/grpc/_simple_stubs.py b/src/python/grpcio/grpc/_simple_stubs.py
index 3e88670aa08..7772860957b 100644
--- a/src/python/grpcio/grpc/_simple_stubs.py
+++ b/src/python/grpcio/grpc/_simple_stubs.py
@@ -159,19 +159,7 @@ class ChannelCache:
         channel_credentials: Optional[grpc.ChannelCredentials],
         insecure: bool,
         compression: Optional[grpc.Compression],
-        method: str,
-        _registered_method: bool,
-    ) -> Tuple[grpc.Channel, Optional[int]]:
-        """Get a channel from cache or creates a new channel.
-
-        This method also takes care of register method for channel,
-          which means we'll register a new call handle if we're calling a
-          non-registered method for an existing channel.
-
-        Returns:
-            A tuple with two items. The first item is the channel, second item is
-              the call handle if the method is registered, None if it's not registered.
-        """
+    ) -> grpc.Channel:
         if insecure and channel_credentials:
             raise ValueError(
                 "The insecure option is mutually exclusive with "
@@ -188,25 +176,18 @@ class ChannelCache:
         key = (target, options, channel_credentials, compression)
         with self._lock:
             channel_data = self._mapping.get(key, None)
-            call_handle = None
             if channel_data is not None:
                 channel = channel_data[0]
-                # Register a new call handle if we're calling a registered method for an
-                # existing channel and this method is not registered.
-                if _registered_method:
-                    call_handle = channel._get_registered_call_handle(method)
                 self._mapping.pop(key)
                 self._mapping[key] = (
                     channel,
                     datetime.datetime.now() + _EVICTION_PERIOD,
                 )
-                return channel, call_handle
+                return channel
             else:
                 channel = _create_channel(
                     target, options, channel_credentials, compression
                 )
-                if _registered_method:
-                    call_handle = channel._get_registered_call_handle(method)
                 self._mapping[key] = (
                     channel,
                     datetime.datetime.now() + _EVICTION_PERIOD,
@@ -216,7 +197,7 @@ class ChannelCache:
                     or len(self._mapping) >= _MAXIMUM_CHANNELS
                 ):
                     self._condition.notify()
-                return channel, call_handle
+                return channel
 
     def _test_only_channel_count(self) -> int:
         with self._lock:
@@ -224,7 +205,6 @@ class ChannelCache:
 
 
 @experimental_api
-# pylint: disable=too-many-locals
 def unary_unary(
     request: RequestType,
     target: str,
@@ -239,7 +219,6 @@ def unary_unary(
     wait_for_ready: Optional[bool] = None,
     timeout: Optional[float] = _DEFAULT_TIMEOUT,
     metadata: Optional[Sequence[Tuple[str, Union[str, bytes]]]] = None,
-    _registered_method: Optional[bool] = False,
 ) -> ResponseType:
     """Invokes a unary-unary RPC without an explicitly specified channel.
 
@@ -293,17 +272,11 @@ def unary_unary(
     Returns:
       The response to the RPC.
     """
-    channel, method_handle = ChannelCache.get().get_channel(
-        target,
-        options,
-        channel_credentials,
-        insecure,
-        compression,
-        method,
-        _registered_method,
+    channel = ChannelCache.get().get_channel(
+        target, options, channel_credentials, insecure, compression
     )
     multicallable = channel.unary_unary(
-        method, request_serializer, response_deserializer, method_handle
+        method, request_serializer, response_deserializer
     )
     wait_for_ready = wait_for_ready if wait_for_ready is not None else True
     return multicallable(
@@ -316,7 +289,6 @@ def unary_unary(
 
 
 @experimental_api
-# pylint: disable=too-many-locals
 def unary_stream(
     request: RequestType,
     target: str,
@@ -331,7 +303,6 @@ def unary_stream(
     wait_for_ready: Optional[bool] = None,
     timeout: Optional[float] = _DEFAULT_TIMEOUT,
     metadata: Optional[Sequence[Tuple[str, Union[str, bytes]]]] = None,
-    _registered_method: Optional[bool] = False,
 ) -> Iterator[ResponseType]:
     """Invokes a unary-stream RPC without an explicitly specified channel.
 
@@ -384,17 +355,11 @@ def unary_stream(
     Returns:
       An iterator of responses.
     """
-    channel, method_handle = ChannelCache.get().get_channel(
-        target,
-        options,
-        channel_credentials,
-        insecure,
-        compression,
-        method,
-        _registered_method,
+    channel = ChannelCache.get().get_channel(
+        target, options, channel_credentials, insecure, compression
     )
     multicallable = channel.unary_stream(
-        method, request_serializer, response_deserializer, method_handle
+        method, request_serializer, response_deserializer
     )
     wait_for_ready = wait_for_ready if wait_for_ready is not None else True
     return multicallable(
@@ -407,7 +372,6 @@ def unary_stream(
 
 
 @experimental_api
-# pylint: disable=too-many-locals
 def stream_unary(
     request_iterator: Iterator[RequestType],
     target: str,
@@ -422,7 +386,6 @@ def stream_unary(
     wait_for_ready: Optional[bool] = None,
     timeout: Optional[float] = _DEFAULT_TIMEOUT,
     metadata: Optional[Sequence[Tuple[str, Union[str, bytes]]]] = None,
-    _registered_method: Optional[bool] = False,
 ) -> ResponseType:
     """Invokes a stream-unary RPC without an explicitly specified channel.
 
@@ -475,17 +438,11 @@ def stream_unary(
     Returns:
       The response to the RPC.
     """
-    channel, method_handle = ChannelCache.get().get_channel(
-        target,
-        options,
-        channel_credentials,
-        insecure,
-        compression,
-        method,
-        _registered_method,
+    channel = ChannelCache.get().get_channel(
+        target, options, channel_credentials, insecure, compression
     )
     multicallable = channel.stream_unary(
-        method, request_serializer, response_deserializer, method_handle
+        method, request_serializer, response_deserializer
     )
     wait_for_ready = wait_for_ready if wait_for_ready is not None else True
     return multicallable(
@@ -498,7 +455,6 @@ def stream_unary(
 
 
 @experimental_api
-# pylint: disable=too-many-locals
 def stream_stream(
     request_iterator: Iterator[RequestType],
     target: str,
@@ -513,7 +469,6 @@ def stream_stream(
     wait_for_ready: Optional[bool] = None,
     timeout: Optional[float] = _DEFAULT_TIMEOUT,
     metadata: Optional[Sequence[Tuple[str, Union[str, bytes]]]] = None,
-    _registered_method: Optional[bool] = False,
 ) -> Iterator[ResponseType]:
     """Invokes a stream-stream RPC without an explicitly specified channel.
 
@@ -566,17 +521,11 @@ def stream_stream(
     Returns:
       An iterator of responses.
     """
-    channel, method_handle = ChannelCache.get().get_channel(
-        target,
-        options,
-        channel_credentials,
-        insecure,
-        compression,
-        method,
-        _registered_method,
+    channel = ChannelCache.get().get_channel(
+        target, options, channel_credentials, insecure, compression
     )
     multicallable = channel.stream_stream(
-        method, request_serializer, response_deserializer, method_handle
+        method, request_serializer, response_deserializer
     )
     wait_for_ready = wait_for_ready if wait_for_ready is not None else True
     return multicallable(
diff --git a/src/python/grpcio/grpc/aio/_channel.py b/src/python/grpcio/grpc/aio/_channel.py
index ea4de20965a..bea64c27fa3 100644
--- a/src/python/grpcio/grpc/aio/_channel.py
+++ b/src/python/grpcio/grpc/aio/_channel.py
@@ -478,20 +478,11 @@ class Channel(_base_channel.Channel):
             await self.wait_for_state_change(state)
             state = self.get_state(try_to_connect=True)
 
-    # TODO(xuanwn): Implement this method after we have
-    # observability for Asyncio.
-    def _get_registered_call_handle(self, method: str) -> int:
-        pass
-
-    # TODO(xuanwn): Implement _registered_method after we have
-    # observability for Asyncio.
-    # pylint: disable=arguments-differ,unused-argument
     def unary_unary(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> UnaryUnaryMultiCallable:
         return UnaryUnaryMultiCallable(
             self._channel,
@@ -503,15 +494,11 @@ class Channel(_base_channel.Channel):
             self._loop,
         )
 
-    # TODO(xuanwn): Implement _registered_method after we have
-    # observability for Asyncio.
-    # pylint: disable=arguments-differ,unused-argument
     def unary_stream(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> UnaryStreamMultiCallable:
         return UnaryStreamMultiCallable(
             self._channel,
@@ -523,15 +510,11 @@ class Channel(_base_channel.Channel):
             self._loop,
         )
 
-    # TODO(xuanwn): Implement _registered_method after we have
-    # observability for Asyncio.
-    # pylint: disable=arguments-differ,unused-argument
     def stream_unary(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> StreamUnaryMultiCallable:
         return StreamUnaryMultiCallable(
             self._channel,
@@ -543,15 +526,11 @@ class Channel(_base_channel.Channel):
             self._loop,
         )
 
-    # TODO(xuanwn): Implement _registered_method after we have
-    # observability for Asyncio.
-    # pylint: disable=arguments-differ,unused-argument
     def stream_stream(
         self,
         method: str,
         request_serializer: Optional[SerializingFunction] = None,
         response_deserializer: Optional[DeserializingFunction] = None,
-        _registered_method: Optional[bool] = False,
     ) -> StreamStreamMultiCallable:
         return StreamStreamMultiCallable(
             self._channel,
diff --git a/src/python/grpcio_testing/grpc_testing/_channel/_channel.py b/src/python/grpcio_testing/grpc_testing/_channel/_channel.py
index 3f12e1f4df8..170533f63ea 100644
--- a/src/python/grpcio_testing/grpc_testing/_channel/_channel.py
+++ b/src/python/grpcio_testing/grpc_testing/_channel/_channel.py
@@ -31,42 +31,23 @@ class TestingChannel(grpc_testing.Channel):
     def unsubscribe(self, callback):
         raise NotImplementedError()
 
-    def _get_registered_call_handle(self, method: str) -> int:
-        pass
-
     def unary_unary(
-        self,
-        method,
-        request_serializer=None,
-        response_deserializer=None,
-        _registered_method=False,
+        self, method, request_serializer=None, response_deserializer=None
     ):
         return _multi_callable.UnaryUnary(method, self._state)
 
     def unary_stream(
-        self,
-        method,
-        request_serializer=None,
-        response_deserializer=None,
-        _registered_method=False,
+        self, method, request_serializer=None, response_deserializer=None
     ):
         return _multi_callable.UnaryStream(method, self._state)
 
     def stream_unary(
-        self,
-        method,
-        request_serializer=None,
-        response_deserializer=None,
-        _registered_method=False,
+        self, method, request_serializer=None, response_deserializer=None
     ):
         return _multi_callable.StreamUnary(method, self._state)
 
     def stream_stream(
-        self,
-        method,
-        request_serializer=None,
-        response_deserializer=None,
-        _registered_method=False,
+        self, method, request_serializer=None, response_deserializer=None
     ):
         return _multi_callable.StreamStream(method, self._state)
 
diff --git a/src/python/grpcio_tests/tests/channelz/_channelz_servicer_test.py b/src/python/grpcio_tests/tests/channelz/_channelz_servicer_test.py
index 2379ab59a3c..78333fc62c7 100644
--- a/src/python/grpcio_tests/tests/channelz/_channelz_servicer_test.py
+++ b/src/python/grpcio_tests/tests/channelz/_channelz_servicer_test.py
@@ -99,20 +99,16 @@ class ChannelzServicerTest(unittest.TestCase):
     def _send_successful_unary_unary(self, idx):
         _, r = (
             self._pairs[idx]
-            .channel.unary_unary(
-                _SUCCESSFUL_UNARY_UNARY,
-                _registered_method=True,
-            )
+            .channel.unary_unary(_SUCCESSFUL_UNARY_UNARY)
             .with_call(_REQUEST)
         )
         self.assertEqual(r.code(), grpc.StatusCode.OK)
 
     def _send_failed_unary_unary(self, idx):
         try:
-            self._pairs[idx].channel.unary_unary(
-                _FAILED_UNARY_UNARY,
-                _registered_method=True,
-            ).with_call(_REQUEST)
+            self._pairs[idx].channel.unary_unary(_FAILED_UNARY_UNARY).with_call(
+                _REQUEST
+            )
         except grpc.RpcError:
             return
         else:
@@ -121,10 +117,7 @@ class ChannelzServicerTest(unittest.TestCase):
     def _send_successful_stream_stream(self, idx):
         response_iterator = (
             self._pairs[idx]
-            .channel.stream_stream(
-                _SUCCESSFUL_STREAM_STREAM,
-                _registered_method=True,
-            )
+            .channel.stream_stream(_SUCCESSFUL_STREAM_STREAM)
             .__call__(iter([_REQUEST] * test_constants.STREAM_LENGTH))
         )
         cnt = 0
diff --git a/src/python/grpcio_tests/tests/csds/csds_test.py b/src/python/grpcio_tests/tests/csds/csds_test.py
index 15bf4e8a49b..c58cb5943d2 100644
--- a/src/python/grpcio_tests/tests/csds/csds_test.py
+++ b/src/python/grpcio_tests/tests/csds/csds_test.py
@@ -92,10 +92,7 @@ class TestCsds(unittest.TestCase):
 
         # Force the XdsClient to initialize and request a resource
         with self.assertRaises(grpc.RpcError) as rpc_error:
-            dummy_channel.unary_unary(
-                "",
-                _registered_method=True,
-            )(b"", wait_for_ready=False, timeout=1)
+            dummy_channel.unary_unary("")(b"", wait_for_ready=False, timeout=1)
         self.assertEqual(
             grpc.StatusCode.DEADLINE_EXCEEDED, rpc_error.exception.code()
         )
diff --git a/src/python/grpcio_tests/tests/protoc_plugin/_python_plugin_test.py b/src/python/grpcio_tests/tests/protoc_plugin/_python_plugin_test.py
index c6e41b3ae8c..9a6538cca35 100644
--- a/src/python/grpcio_tests/tests/protoc_plugin/_python_plugin_test.py
+++ b/src/python/grpcio_tests/tests/protoc_plugin/_python_plugin_test.py
@@ -543,17 +543,6 @@ class PythonPluginTest(unittest.TestCase):
         )
         service.server.stop(None)
 
-    def testRegisteredMethod(self):
-        """Tests that we're setting _registered_call_handle when create call using generated stub."""
-        service = _CreateService()
-        self.assertTrue(service.stub.UnaryCall._registered_call_handle)
-        self.assertTrue(
-            service.stub.StreamingOutputCall._registered_call_handle
-        )
-        self.assertTrue(service.stub.StreamingInputCall._registered_call_handle)
-        self.assertTrue(service.stub.FullDuplexCall._registered_call_handle)
-        service.server.stop(None)
-
 
 @unittest.skipIf(
     sys.version_info[0] < 3 or sys.version_info[1] < 6,
diff --git a/src/python/grpcio_tests/tests/qps/benchmark_client.py b/src/python/grpcio_tests/tests/qps/benchmark_client.py
index 9310f8a8c61..e5aafc4142f 100644
--- a/src/python/grpcio_tests/tests/qps/benchmark_client.py
+++ b/src/python/grpcio_tests/tests/qps/benchmark_client.py
@@ -32,16 +32,13 @@ _TIMEOUT = 60 * 60 * 24
 class GenericStub(object):
     def __init__(self, channel):
         self.UnaryCall = channel.unary_unary(
-            "/grpc.testing.BenchmarkService/UnaryCall",
-            _registered_method=True,
+            "/grpc.testing.BenchmarkService/UnaryCall"
         )
         self.StreamingFromServer = channel.unary_stream(
-            "/grpc.testing.BenchmarkService/StreamingFromServer",
-            _registered_method=True,
+            "/grpc.testing.BenchmarkService/StreamingFromServer"
         )
         self.StreamingCall = channel.stream_stream(
-            "/grpc.testing.BenchmarkService/StreamingCall",
-            _registered_method=True,
+            "/grpc.testing.BenchmarkService/StreamingCall"
         )
 
 
diff --git a/src/python/grpcio_tests/tests/status/_grpc_status_test.py b/src/python/grpcio_tests/tests/status/_grpc_status_test.py
index 031bdbe4d53..2573e961f18 100644
--- a/src/python/grpcio_tests/tests/status/_grpc_status_test.py
+++ b/src/python/grpcio_tests/tests/status/_grpc_status_test.py
@@ -138,10 +138,7 @@ class StatusTest(unittest.TestCase):
         self._channel.close()
 
     def test_status_ok(self):
-        _, call = self._channel.unary_unary(
-            _STATUS_OK,
-            _registered_method=True,
-        ).with_call(_REQUEST)
+        _, call = self._channel.unary_unary(_STATUS_OK).with_call(_REQUEST)
 
         # Succeed RPC doesn't have status
         status = rpc_status.from_call(call)
@@ -149,10 +146,7 @@ class StatusTest(unittest.TestCase):
 
     def test_status_not_ok(self):
         with self.assertRaises(grpc.RpcError) as exception_context:
-            self._channel.unary_unary(
-                _STATUS_NOT_OK,
-                _registered_method=True,
-            ).with_call(_REQUEST)
+            self._channel.unary_unary(_STATUS_NOT_OK).with_call(_REQUEST)
         rpc_error = exception_context.exception
 
         self.assertEqual(rpc_error.code(), grpc.StatusCode.INTERNAL)
@@ -162,10 +156,7 @@ class StatusTest(unittest.TestCase):
 
     def test_error_details(self):
         with self.assertRaises(grpc.RpcError) as exception_context:
-            self._channel.unary_unary(
-                _ERROR_DETAILS,
-                _registered_method=True,
-            ).with_call(_REQUEST)
+            self._channel.unary_unary(_ERROR_DETAILS).with_call(_REQUEST)
         rpc_error = exception_context.exception
 
         status = rpc_status.from_call(rpc_error)
@@ -182,10 +173,7 @@ class StatusTest(unittest.TestCase):
 
     def test_code_message_validation(self):
         with self.assertRaises(grpc.RpcError) as exception_context:
-            self._channel.unary_unary(
-                _INCONSISTENT,
-                _registered_method=True,
-            ).with_call(_REQUEST)
+            self._channel.unary_unary(_INCONSISTENT).with_call(_REQUEST)
         rpc_error = exception_context.exception
         self.assertEqual(rpc_error.code(), grpc.StatusCode.NOT_FOUND)
 
@@ -194,10 +182,7 @@ class StatusTest(unittest.TestCase):
 
     def test_invalid_code(self):
         with self.assertRaises(grpc.RpcError) as exception_context:
-            self._channel.unary_unary(
-                _INVALID_CODE,
-                _registered_method=True,
-            ).with_call(_REQUEST)
+            self._channel.unary_unary(_INVALID_CODE).with_call(_REQUEST)
         rpc_error = exception_context.exception
         self.assertEqual(rpc_error.code(), grpc.StatusCode.UNKNOWN)
         # Invalid status code exception raised during coversion
diff --git a/src/python/grpcio_tests/tests/unit/_abort_test.py b/src/python/grpcio_tests/tests/unit/_abort_test.py
index 46f48bd1cae..731bb741bec 100644
--- a/src/python/grpcio_tests/tests/unit/_abort_test.py
+++ b/src/python/grpcio_tests/tests/unit/_abort_test.py
@@ -107,10 +107,7 @@ class AbortTest(unittest.TestCase):
 
     def test_abort(self):
         with self.assertRaises(grpc.RpcError) as exception_context:
-            self._channel.unary_unary(
-                _ABORT,
-                _registered_method=True,
-            )(_REQUEST)
+            self._channel.unary_unary(_ABORT)(_REQUEST)
         rpc_error = exception_context.exception
 
         self.assertEqual(rpc_error.code(), grpc.StatusCode.INTERNAL)
@@ -127,10 +124,7 @@ class AbortTest(unittest.TestCase):
 
         # Servicer will abort() after creating a local ref to do_not_leak_me.
         with self.assertRaises(grpc.RpcError):
-            self._channel.unary_unary(
-                _ABORT,
-                _registered_method=True,
-            )(_REQUEST)
+            self._channel.unary_unary(_ABORT)(_REQUEST)
 
         # Server may still have a stack frame reference to the exception even
         # after client sees error, so ensure server has shutdown.
@@ -140,10 +134,7 @@ class AbortTest(unittest.TestCase):
 
     def test_abort_with_status(self):
         with self.assertRaises(grpc.RpcError) as exception_context:
-            self._channel.unary_unary(
-                _ABORT_WITH_STATUS,
-                _registered_method=True,
-            )(_REQUEST)
+            self._channel.unary_unary(_ABORT_WITH_STATUS)(_REQUEST)
         rpc_error = exception_context.exception
 
         self.assertEqual(rpc_error.code(), grpc.StatusCode.INTERNAL)
@@ -152,10 +143,7 @@ class AbortTest(unittest.TestCase):
 
     def test_invalid_code(self):
         with self.assertRaises(grpc.RpcError) as exception_context:
-            self._channel.unary_unary(
-                _INVALID_CODE,
-                _registered_method=True,
-            )(_REQUEST)
+            self._channel.unary_unary(_INVALID_CODE)(_REQUEST)
         rpc_error = exception_context.exception
 
         self.assertEqual(rpc_error.code(), grpc.StatusCode.UNKNOWN)
diff --git a/src/python/grpcio_tests/tests/unit/_auth_context_test.py b/src/python/grpcio_tests/tests/unit/_auth_context_test.py
index 0e5e2017fba..039c908c3e5 100644
--- a/src/python/grpcio_tests/tests/unit/_auth_context_test.py
+++ b/src/python/grpcio_tests/tests/unit/_auth_context_test.py
@@ -78,10 +78,7 @@ class AuthContextTest(unittest.TestCase):
         server.start()
 
         with grpc.insecure_channel("localhost:%d" % port) as channel:
-            response = channel.unary_unary(
-                _UNARY_UNARY,
-                _registered_method=True,
-            )(_REQUEST)
+            response = channel.unary_unary(_UNARY_UNARY)(_REQUEST)
         server.stop(None)
 
         auth_data = pickle.loads(response)
@@ -118,10 +115,7 @@ class AuthContextTest(unittest.TestCase):
             channel_creds,
             options=_PROPERTY_OPTIONS,
         )
-        response = channel.unary_unary(
-            _UNARY_UNARY,
-            _registered_method=True,
-        )(_REQUEST)
+        response = channel.unary_unary(_UNARY_UNARY)(_REQUEST)
         channel.close()
         server.stop(None)
 
@@ -167,10 +161,7 @@ class AuthContextTest(unittest.TestCase):
             options=_PROPERTY_OPTIONS,
         )
 
-        response = channel.unary_unary(
-            _UNARY_UNARY,
-            _registered_method=True,
-        )(_REQUEST)
+        response = channel.unary_unary(_UNARY_UNARY)(_REQUEST)
         channel.close()
         server.stop(None)
 
@@ -189,10 +180,7 @@ class AuthContextTest(unittest.TestCase):
         channel = grpc.secure_channel(
             "localhost:{}".format(port), channel_creds, options=channel_options
         )
-        response = channel.unary_unary(
-            _UNARY_UNARY,
-            _registered_method=True,
-        )(_REQUEST)
+        response = channel.unary_unary(_UNARY_UNARY)(_REQUEST)
         auth_data = pickle.loads(response)
         self.assertEqual(
             expect_ssl_session_reused,
diff --git a/src/python/grpcio_tests/tests/unit/_channel_close_test.py b/src/python/grpcio_tests/tests/unit/_channel_close_test.py
index b2ba4e7c887..4e5f215af89 100644
--- a/src/python/grpcio_tests/tests/unit/_channel_close_test.py
+++ b/src/python/grpcio_tests/tests/unit/_channel_close_test.py
@@ -123,10 +123,7 @@ class ChannelCloseTest(unittest.TestCase):
 
     def test_close_immediately_after_call_invocation(self):
         channel = grpc.insecure_channel("localhost:{}".format(self._port))
-        multi_callable = channel.stream_stream(
-            _STREAM_URI,
-            _registered_method=True,
-        )
+        multi_callable = channel.stream_stream(_STREAM_URI)
         request_iterator = _Pipe(())
         response_iterator = multi_callable(request_iterator)
         channel.close()
@@ -136,10 +133,7 @@ class ChannelCloseTest(unittest.TestCase):
 
     def test_close_while_call_active(self):
         channel = grpc.insecure_channel("localhost:{}".format(self._port))
-        multi_callable = channel.stream_stream(
-            _STREAM_URI,
-            _registered_method=True,
-        )
+        multi_callable = channel.stream_stream(_STREAM_URI)
         request_iterator = _Pipe((b"abc",))
         response_iterator = multi_callable(request_iterator)
         next(response_iterator)
@@ -152,10 +146,7 @@ class ChannelCloseTest(unittest.TestCase):
         with grpc.insecure_channel(
             "localhost:{}".format(self._port)
         ) as channel:  # pylint: disable=bad-continuation
-            multi_callable = channel.stream_stream(
-                _STREAM_URI,
-                _registered_method=True,
-            )
+            multi_callable = channel.stream_stream(_STREAM_URI)
             request_iterator = _Pipe((b"abc",))
             response_iterator = multi_callable(request_iterator)
             next(response_iterator)
@@ -167,10 +158,7 @@ class ChannelCloseTest(unittest.TestCase):
         with grpc.insecure_channel(
             "localhost:{}".format(self._port)
         ) as channel:  # pylint: disable=bad-continuation
-            multi_callable = channel.stream_stream(
-                _STREAM_URI,
-                _registered_method=True,
-            )
+            multi_callable = channel.stream_stream(_STREAM_URI)
             request_iterators = tuple(
                 _Pipe((b"abc",))
                 for _ in range(test_constants.THREAD_CONCURRENCY)
@@ -188,10 +176,7 @@ class ChannelCloseTest(unittest.TestCase):
 
     def test_many_concurrent_closes(self):
         channel = grpc.insecure_channel("localhost:{}".format(self._port))
-        multi_callable = channel.stream_stream(
-            _STREAM_URI,
-            _registered_method=True,
-        )
+        multi_callable = channel.stream_stream(_STREAM_URI)
         request_iterator = _Pipe((b"abc",))
         response_iterator = multi_callable(request_iterator)
         next(response_iterator)
@@ -218,16 +203,10 @@ class ChannelCloseTest(unittest.TestCase):
         with grpc.insecure_channel(
             "localhost:{}".format(self._port)
         ) as channel:
-            stream_multi_callable = channel.stream_stream(
-                _STREAM_URI,
-                _registered_method=True,
-            )
+            stream_multi_callable = channel.stream_stream(_STREAM_URI)
             endless_iterator = itertools.repeat(b"abc")
             stream_response_iterator = stream_multi_callable(endless_iterator)
-            future = channel.unary_unary(
-                _UNARY_URI,
-                _registered_method=True,
-            ).future(b"abc")
+            future = channel.unary_unary(_UNARY_URI).future(b"abc")
 
             def on_done_callback(future):
                 raise Exception("This should not cause a deadlock.")
diff --git a/src/python/grpcio_tests/tests/unit/_compression_test.py b/src/python/grpcio_tests/tests/unit/_compression_test.py
index 9fdeca030d8..be2a528ea9b 100644
--- a/src/python/grpcio_tests/tests/unit/_compression_test.py
+++ b/src/python/grpcio_tests/tests/unit/_compression_test.py
@@ -237,10 +237,7 @@ def _get_compression_ratios(
 
 
 def _unary_unary_client(channel, multicallable_kwargs, message):
-    multi_callable = channel.unary_unary(
-        _UNARY_UNARY,
-        _registered_method=True,
-    )
+    multi_callable = channel.unary_unary(_UNARY_UNARY)
     response = multi_callable(message, **multicallable_kwargs)
     if response != message:
         raise RuntimeError(
@@ -249,10 +246,7 @@ def _unary_unary_client(channel, multicallable_kwargs, message):
 
 
 def _unary_stream_client(channel, multicallable_kwargs, message):
-    multi_callable = channel.unary_stream(
-        _UNARY_STREAM,
-        _registered_method=True,
-    )
+    multi_callable = channel.unary_stream(_UNARY_STREAM)
     response_iterator = multi_callable(message, **multicallable_kwargs)
     for response in response_iterator:
         if response != message:
@@ -262,10 +256,7 @@ def _unary_stream_client(channel, multicallable_kwargs, message):
 
 
 def _stream_unary_client(channel, multicallable_kwargs, message):
-    multi_callable = channel.stream_unary(
-        _STREAM_UNARY,
-        _registered_method=True,
-    )
+    multi_callable = channel.stream_unary(_STREAM_UNARY)
     requests = (_REQUEST for _ in range(_STREAM_LENGTH))
     response = multi_callable(requests, **multicallable_kwargs)
     if response != message:
@@ -275,10 +266,7 @@ def _stream_unary_client(channel, multicallable_kwargs, message):
 
 
 def _stream_stream_client(channel, multicallable_kwargs, message):
-    multi_callable = channel.stream_stream(
-        _STREAM_STREAM,
-        _registered_method=True,
-    )
+    multi_callable = channel.stream_stream(_STREAM_STREAM)
     request_prefix = str(0).encode("ascii") * 100
     requests = (
         request_prefix + str(i).encode("ascii") for i in range(_STREAM_LENGTH)
diff --git a/src/python/grpcio_tests/tests/unit/_contextvars_propagation_test.py b/src/python/grpcio_tests/tests/unit/_contextvars_propagation_test.py
index 5a23d5dc69e..6f3b601ceb2 100644
--- a/src/python/grpcio_tests/tests/unit/_contextvars_propagation_test.py
+++ b/src/python/grpcio_tests/tests/unit/_contextvars_propagation_test.py
@@ -116,10 +116,7 @@ class ContextVarsPropagationTest(unittest.TestCase):
                 local_credentials, call_credentials
             )
             with grpc.secure_channel(target, composite_credentials) as channel:
-                stub = channel.unary_unary(
-                    _UNARY_UNARY,
-                    _registered_method=True,
-                )
+                stub = channel.unary_unary(_UNARY_UNARY)
                 response = stub(_REQUEST, wait_for_ready=True)
                 self.assertEqual(_REQUEST, response)
 
@@ -145,10 +142,7 @@ class ContextVarsPropagationTest(unittest.TestCase):
                     with grpc.secure_channel(
                         target, composite_credentials
                     ) as channel:
-                        stub = channel.unary_unary(
-                            _UNARY_UNARY,
-                            _registered_method=True,
-                        )
+                        stub = channel.unary_unary(_UNARY_UNARY)
                         wait_group.done()
                         wait_group.wait()
                         for i in range(_RPC_COUNT):
diff --git a/src/python/grpcio_tests/tests/unit/_dns_resolver_test.py b/src/python/grpcio_tests/tests/unit/_dns_resolver_test.py
index bcd7e6da849..62a95a02135 100644
--- a/src/python/grpcio_tests/tests/unit/_dns_resolver_test.py
+++ b/src/python/grpcio_tests/tests/unit/_dns_resolver_test.py
@@ -55,10 +55,7 @@ class DNSResolverTest(unittest.TestCase):
             "loopback46.unittest.grpc.io:%d" % self._port
         ) as channel:
             self.assertEqual(
-                channel.unary_unary(
-                    _METHOD,
-                    _registered_method=True,
-                )(
+                channel.unary_unary(_METHOD)(
                     _REQUEST,
                     timeout=10,
                 ),
diff --git a/src/python/grpcio_tests/tests/unit/_empty_message_test.py b/src/python/grpcio_tests/tests/unit/_empty_message_test.py
index a303aa8b3e9..e2dc1594202 100644
--- a/src/python/grpcio_tests/tests/unit/_empty_message_test.py
+++ b/src/python/grpcio_tests/tests/unit/_empty_message_test.py
@@ -96,33 +96,25 @@ class EmptyMessageTest(unittest.TestCase):
         self._channel.close()
 
     def testUnaryUnary(self):
-        response = self._channel.unary_unary(
-            _UNARY_UNARY,
-            _registered_method=True,
-        )(_REQUEST)
+        response = self._channel.unary_unary(_UNARY_UNARY)(_REQUEST)
         self.assertEqual(_RESPONSE, response)
 
     def testUnaryStream(self):
-        response_iterator = self._channel.unary_stream(
-            _UNARY_STREAM,
-            _registered_method=True,
-        )(_REQUEST)
+        response_iterator = self._channel.unary_stream(_UNARY_STREAM)(_REQUEST)
         self.assertSequenceEqual(
             [_RESPONSE] * test_constants.STREAM_LENGTH, list(response_iterator)
         )
 
     def testStreamUnary(self):
-        response = self._channel.stream_unary(
-            _STREAM_UNARY,
-            _registered_method=True,
-        )(iter([_REQUEST] * test_constants.STREAM_LENGTH))
+        response = self._channel.stream_unary(_STREAM_UNARY)(
+            iter([_REQUEST] * test_constants.STREAM_LENGTH)
+        )
         self.assertEqual(_RESPONSE, response)
 
     def testStreamStream(self):
-        response_iterator = self._channel.stream_stream(
-            _STREAM_STREAM,
-            _registered_method=True,
-        )(iter([_REQUEST] * test_constants.STREAM_LENGTH))
+        response_iterator = self._channel.stream_stream(_STREAM_STREAM)(
+            iter([_REQUEST] * test_constants.STREAM_LENGTH)
+        )
         self.assertSequenceEqual(
             [_RESPONSE] * test_constants.STREAM_LENGTH, list(response_iterator)
         )
diff --git a/src/python/grpcio_tests/tests/unit/_error_message_encoding_test.py b/src/python/grpcio_tests/tests/unit/_error_message_encoding_test.py
index 334b7ed5a3a..4f07477fac9 100644
--- a/src/python/grpcio_tests/tests/unit/_error_message_encoding_test.py
+++ b/src/python/grpcio_tests/tests/unit/_error_message_encoding_test.py
@@ -73,10 +73,7 @@ class ErrorMessageEncodingTest(unittest.TestCase):
 
     def testMessageEncoding(self):
         for message in _UNICODE_ERROR_MESSAGES:
-            multi_callable = self._channel.unary_unary(
-                _UNARY_UNARY,
-                _registered_method=True,
-            )
+            multi_callable = self._channel.unary_unary(_UNARY_UNARY)
             with self.assertRaises(grpc.RpcError) as cm:
                 multi_callable(message.encode("utf-8"))
 
diff --git a/src/python/grpcio_tests/tests/unit/_exit_scenarios.py b/src/python/grpcio_tests/tests/unit/_exit_scenarios.py
index 1b7e2e5ac84..c1f9816df08 100644
--- a/src/python/grpcio_tests/tests/unit/_exit_scenarios.py
+++ b/src/python/grpcio_tests/tests/unit/_exit_scenarios.py
@@ -210,20 +210,14 @@ if __name__ == "__main__":
         method = TEST_TO_METHOD[args.scenario]
 
         if args.scenario == IN_FLIGHT_UNARY_UNARY_CALL:
-            multi_callable = channel.unary_unary(
-                method,
-                _registered_method=True,
-            )
+            multi_callable = channel.unary_unary(method)
             future = multi_callable.future(REQUEST)
             result, call = multi_callable.with_call(REQUEST)
         elif (
             args.scenario == IN_FLIGHT_UNARY_STREAM_CALL
             or args.scenario == IN_FLIGHT_PARTIAL_UNARY_STREAM_CALL
         ):
-            multi_callable = channel.unary_stream(
-                method,
-                _registered_method=True,
-            )
+            multi_callable = channel.unary_stream(method)
             response_iterator = multi_callable(REQUEST)
             for response in response_iterator:
                 pass
@@ -231,10 +225,7 @@ if __name__ == "__main__":
             args.scenario == IN_FLIGHT_STREAM_UNARY_CALL
             or args.scenario == IN_FLIGHT_PARTIAL_STREAM_UNARY_CALL
         ):
-            multi_callable = channel.stream_unary(
-                method,
-                _registered_method=True,
-            )
+            multi_callable = channel.stream_unary(method)
             future = multi_callable.future(infinite_request_iterator())
             result, call = multi_callable.with_call(
                 iter([REQUEST] * test_constants.STREAM_LENGTH)
@@ -243,10 +234,7 @@ if __name__ == "__main__":
             args.scenario == IN_FLIGHT_STREAM_STREAM_CALL
             or args.scenario == IN_FLIGHT_PARTIAL_STREAM_STREAM_CALL
         ):
-            multi_callable = channel.stream_stream(
-                method,
-                _registered_method=True,
-            )
+            multi_callable = channel.stream_stream(method)
             response_iterator = multi_callable(infinite_request_iterator())
             for response in response_iterator:
                 pass
diff --git a/src/python/grpcio_tests/tests/unit/_interceptor_test.py b/src/python/grpcio_tests/tests/unit/_interceptor_test.py
index 72e299b5887..9bbff1f6bee 100644
--- a/src/python/grpcio_tests/tests/unit/_interceptor_test.py
+++ b/src/python/grpcio_tests/tests/unit/_interceptor_test.py
@@ -231,7 +231,7 @@ class _GenericHandler(grpc.GenericRpcHandler):
 
 
 def _unary_unary_multi_callable(channel):
-    return channel.unary_unary(_UNARY_UNARY, _registered_method=True)
+    return channel.unary_unary(_UNARY_UNARY)
 
 
 def _unary_stream_multi_callable(channel):
@@ -239,7 +239,6 @@ def _unary_stream_multi_callable(channel):
         _UNARY_STREAM,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
@@ -248,12 +247,11 @@ def _stream_unary_multi_callable(channel):
         _STREAM_UNARY,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
 def _stream_stream_multi_callable(channel):
-    return channel.stream_stream(_STREAM_STREAM, _registered_method=True)
+    return channel.stream_stream(_STREAM_STREAM)
 
 
 class _ClientCallDetails(
@@ -564,7 +562,7 @@ class InterceptorTest(unittest.TestCase):
         self._record[:] = []
 
         multi_callable = _unary_unary_multi_callable(channel)
-        response, call = multi_callable.with_call(
+        multi_callable.with_call(
             request,
             metadata=(
                 (
diff --git a/src/python/grpcio_tests/tests/unit/_invalid_metadata_test.py b/src/python/grpcio_tests/tests/unit/_invalid_metadata_test.py
index 58d1e589fde..a19966131c5 100644
--- a/src/python/grpcio_tests/tests/unit/_invalid_metadata_test.py
+++ b/src/python/grpcio_tests/tests/unit/_invalid_metadata_test.py
@@ -32,7 +32,7 @@ _STREAM_STREAM = "/test/StreamStream"
 
 
 def _unary_unary_multi_callable(channel):
-    return channel.unary_unary(_UNARY_UNARY, _registered_method=True)
+    return channel.unary_unary(_UNARY_UNARY)
 
 
 def _unary_stream_multi_callable(channel):
@@ -40,7 +40,6 @@ def _unary_stream_multi_callable(channel):
         _UNARY_STREAM,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
@@ -49,15 +48,11 @@ def _stream_unary_multi_callable(channel):
         _STREAM_UNARY,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
 def _stream_stream_multi_callable(channel):
-    return channel.stream_stream(
-        _STREAM_STREAM,
-        _registered_method=True,
-    )
+    return channel.stream_stream(_STREAM_STREAM)
 
 
 class InvalidMetadataTest(unittest.TestCase):
diff --git a/src/python/grpcio_tests/tests/unit/_invocation_defects_test.py b/src/python/grpcio_tests/tests/unit/_invocation_defects_test.py
index cb903e7b812..b22ab016593 100644
--- a/src/python/grpcio_tests/tests/unit/_invocation_defects_test.py
+++ b/src/python/grpcio_tests/tests/unit/_invocation_defects_test.py
@@ -219,10 +219,7 @@ class FailAfterFewIterationsCounter(object):
 
 
 def _unary_unary_multi_callable(channel):
-    return channel.unary_unary(
-        _UNARY_UNARY,
-        _registered_method=True,
-    )
+    return channel.unary_unary(_UNARY_UNARY)
 
 
 def _unary_stream_multi_callable(channel):
@@ -230,7 +227,6 @@ def _unary_stream_multi_callable(channel):
         _UNARY_STREAM,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
@@ -239,29 +235,19 @@ def _stream_unary_multi_callable(channel):
         _STREAM_UNARY,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
 def _stream_stream_multi_callable(channel):
-    return channel.stream_stream(
-        _STREAM_STREAM,
-        _registered_method=True,
-    )
+    return channel.stream_stream(_STREAM_STREAM)
 
 
 def _defective_handler_multi_callable(channel):
-    return channel.unary_unary(
-        _DEFECTIVE_GENERIC_RPC_HANDLER,
-        _registered_method=True,
-    )
+    return channel.unary_unary(_DEFECTIVE_GENERIC_RPC_HANDLER)
 
 
 def _defective_nested_exception_handler_multi_callable(channel):
-    return channel.unary_unary(
-        _UNARY_UNARY_NESTED_EXCEPTION,
-        _registered_method=True,
-    )
+    return channel.unary_unary(_UNARY_UNARY_NESTED_EXCEPTION)
 
 
 class InvocationDefectsTest(unittest.TestCase):
diff --git a/src/python/grpcio_tests/tests/unit/_local_credentials_test.py b/src/python/grpcio_tests/tests/unit/_local_credentials_test.py
index 9c5b425eaf7..165f6ca16eb 100644
--- a/src/python/grpcio_tests/tests/unit/_local_credentials_test.py
+++ b/src/python/grpcio_tests/tests/unit/_local_credentials_test.py
@@ -53,10 +53,9 @@ class LocalCredentialsTest(unittest.TestCase):
         ) as channel:
             self.assertEqual(
                 b"abc",
-                channel.unary_unary(
-                    "/test/method",
-                    _registered_method=True,
-                )(b"abc", wait_for_ready=True),
+                channel.unary_unary("/test/method")(
+                    b"abc", wait_for_ready=True
+                ),
             )
         server.stop(None)
 
@@ -78,10 +77,9 @@ class LocalCredentialsTest(unittest.TestCase):
         with grpc.secure_channel(server_addr, channel_creds) as channel:
             self.assertEqual(
                 b"abc",
-                channel.unary_unary(
-                    "/test/method",
-                    _registered_method=True,
-                )(b"abc", wait_for_ready=True),
+                channel.unary_unary("/test/method")(
+                    b"abc", wait_for_ready=True
+                ),
             )
         server.stop(None)
 
diff --git a/src/python/grpcio_tests/tests/unit/_metadata_code_details_test.py b/src/python/grpcio_tests/tests/unit/_metadata_code_details_test.py
index 320deb7e5f6..3c530058dc3 100644
--- a/src/python/grpcio_tests/tests/unit/_metadata_code_details_test.py
+++ b/src/python/grpcio_tests/tests/unit/_metadata_code_details_test.py
@@ -207,53 +207,45 @@ class MetadataCodeDetailsTest(unittest.TestCase):
         self._server.start()
 
         self._channel = grpc.insecure_channel("localhost:{}".format(port))
-        unary_unary_method_name = "/".join(
-            (
-                "",
-                _SERVICE,
-                _UNARY_UNARY,
-            )
-        )
         self._unary_unary = self._channel.unary_unary(
-            unary_unary_method_name,
+            "/".join(
+                (
+                    "",
+                    _SERVICE,
+                    _UNARY_UNARY,
+                )
+            ),
             request_serializer=_REQUEST_SERIALIZER,
             response_deserializer=_RESPONSE_DESERIALIZER,
-            _registered_method=True,
-        )
-        unary_stream_method_name = "/".join(
-            (
-                "",
-                _SERVICE,
-                _UNARY_STREAM,
-            )
         )
         self._unary_stream = self._channel.unary_stream(
-            unary_stream_method_name,
-            _registered_method=True,
-        )
-        stream_unary_method_name = "/".join(
-            (
-                "",
-                _SERVICE,
-                _STREAM_UNARY,
-            )
+            "/".join(
+                (
+                    "",
+                    _SERVICE,
+                    _UNARY_STREAM,
+                )
+            ),
         )
         self._stream_unary = self._channel.stream_unary(
-            stream_unary_method_name,
-            _registered_method=True,
-        )
-        stream_stream_method_name = "/".join(
-            (
-                "",
-                _SERVICE,
-                _STREAM_STREAM,
-            )
+            "/".join(
+                (
+                    "",
+                    _SERVICE,
+                    _STREAM_UNARY,
+                )
+            ),
         )
         self._stream_stream = self._channel.stream_stream(
-            stream_stream_method_name,
+            "/".join(
+                (
+                    "",
+                    _SERVICE,
+                    _STREAM_STREAM,
+                )
+            ),
             request_serializer=_REQUEST_SERIALIZER,
             response_deserializer=_RESPONSE_DESERIALIZER,
-            _registered_method=True,
         )
 
     def tearDown(self):
@@ -836,18 +828,16 @@ class InspectContextTest(unittest.TestCase):
         self._server.start()
 
         self._channel = grpc.insecure_channel("localhost:{}".format(port))
-        unary_unary_method_name = "/".join(
-            (
-                "",
-                _SERVICE,
-                _UNARY_UNARY,
-            )
-        )
         self._unary_unary = self._channel.unary_unary(
-            unary_unary_method_name,
+            "/".join(
+                (
+                    "",
+                    _SERVICE,
+                    _UNARY_UNARY,
+                )
+            ),
             request_serializer=_REQUEST_SERIALIZER,
             response_deserializer=_RESPONSE_DESERIALIZER,
-            _registered_method=True,
         )
 
     def tearDown(self):
diff --git a/src/python/grpcio_tests/tests/unit/_metadata_flags_test.py b/src/python/grpcio_tests/tests/unit/_metadata_flags_test.py
index 2cd9ad9bd89..a67a496860f 100644
--- a/src/python/grpcio_tests/tests/unit/_metadata_flags_test.py
+++ b/src/python/grpcio_tests/tests/unit/_metadata_flags_test.py
@@ -110,10 +110,7 @@ def create_phony_channel():
 
 
 def perform_unary_unary_call(channel, wait_for_ready=None):
-    channel.unary_unary(
-        _UNARY_UNARY,
-        _registered_method=True,
-    ).__call__(
+    channel.unary_unary(_UNARY_UNARY).__call__(
         _REQUEST,
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
@@ -121,10 +118,7 @@ def perform_unary_unary_call(channel, wait_for_ready=None):
 
 
 def perform_unary_unary_with_call(channel, wait_for_ready=None):
-    channel.unary_unary(
-        _UNARY_UNARY,
-        _registered_method=True,
-    ).with_call(
+    channel.unary_unary(_UNARY_UNARY).with_call(
         _REQUEST,
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
@@ -132,10 +126,7 @@ def perform_unary_unary_with_call(channel, wait_for_ready=None):
 
 
 def perform_unary_unary_future(channel, wait_for_ready=None):
-    channel.unary_unary(
-        _UNARY_UNARY,
-        _registered_method=True,
-    ).future(
+    channel.unary_unary(_UNARY_UNARY).future(
         _REQUEST,
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
@@ -143,10 +134,7 @@ def perform_unary_unary_future(channel, wait_for_ready=None):
 
 
 def perform_unary_stream_call(channel, wait_for_ready=None):
-    response_iterator = channel.unary_stream(
-        _UNARY_STREAM,
-        _registered_method=True,
-    ).__call__(
+    response_iterator = channel.unary_stream(_UNARY_STREAM).__call__(
         _REQUEST,
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
@@ -156,10 +144,7 @@ def perform_unary_stream_call(channel, wait_for_ready=None):
 
 
 def perform_stream_unary_call(channel, wait_for_ready=None):
-    channel.stream_unary(
-        _STREAM_UNARY,
-        _registered_method=True,
-    ).__call__(
+    channel.stream_unary(_STREAM_UNARY).__call__(
         iter([_REQUEST] * test_constants.STREAM_LENGTH),
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
@@ -167,10 +152,7 @@ def perform_stream_unary_call(channel, wait_for_ready=None):
 
 
 def perform_stream_unary_with_call(channel, wait_for_ready=None):
-    channel.stream_unary(
-        _STREAM_UNARY,
-        _registered_method=True,
-    ).with_call(
+    channel.stream_unary(_STREAM_UNARY).with_call(
         iter([_REQUEST] * test_constants.STREAM_LENGTH),
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
@@ -178,10 +160,7 @@ def perform_stream_unary_with_call(channel, wait_for_ready=None):
 
 
 def perform_stream_unary_future(channel, wait_for_ready=None):
-    channel.stream_unary(
-        _STREAM_UNARY,
-        _registered_method=True,
-    ).future(
+    channel.stream_unary(_STREAM_UNARY).future(
         iter([_REQUEST] * test_constants.STREAM_LENGTH),
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
@@ -189,9 +168,7 @@ def perform_stream_unary_future(channel, wait_for_ready=None):
 
 
 def perform_stream_stream_call(channel, wait_for_ready=None):
-    response_iterator = channel.stream_stream(
-        _STREAM_STREAM, _registered_method=True
-    ).__call__(
+    response_iterator = channel.stream_stream(_STREAM_STREAM).__call__(
         iter([_REQUEST] * test_constants.STREAM_LENGTH),
         timeout=test_constants.LONG_TIMEOUT,
         wait_for_ready=wait_for_ready,
diff --git a/src/python/grpcio_tests/tests/unit/_metadata_test.py b/src/python/grpcio_tests/tests/unit/_metadata_test.py
index b9b7502972c..7110177fa18 100644
--- a/src/python/grpcio_tests/tests/unit/_metadata_test.py
+++ b/src/python/grpcio_tests/tests/unit/_metadata_test.py
@@ -195,9 +195,7 @@ class MetadataTest(unittest.TestCase):
         self._channel.close()
 
     def testUnaryUnary(self):
-        multi_callable = self._channel.unary_unary(
-            _UNARY_UNARY, _registered_method=True
-        )
+        multi_callable = self._channel.unary_unary(_UNARY_UNARY)
         unused_response, call = multi_callable.with_call(
             _REQUEST, metadata=_INVOCATION_METADATA
         )
@@ -213,9 +211,7 @@ class MetadataTest(unittest.TestCase):
         )
 
     def testUnaryStream(self):
-        multi_callable = self._channel.unary_stream(
-            _UNARY_STREAM, _registered_method=True
-        )
+        multi_callable = self._channel.unary_stream(_UNARY_STREAM)
         call = multi_callable(_REQUEST, metadata=_INVOCATION_METADATA)
         self.assertTrue(
             test_common.metadata_transmitted(
@@ -231,9 +227,7 @@ class MetadataTest(unittest.TestCase):
         )
 
     def testStreamUnary(self):
-        multi_callable = self._channel.stream_unary(
-            _STREAM_UNARY, _registered_method=True
-        )
+        multi_callable = self._channel.stream_unary(_STREAM_UNARY)
         unused_response, call = multi_callable.with_call(
             iter([_REQUEST] * test_constants.STREAM_LENGTH),
             metadata=_INVOCATION_METADATA,
@@ -250,9 +244,7 @@ class MetadataTest(unittest.TestCase):
         )
 
     def testStreamStream(self):
-        multi_callable = self._channel.stream_stream(
-            _STREAM_STREAM, _registered_method=True
-        )
+        multi_callable = self._channel.stream_stream(_STREAM_STREAM)
         call = multi_callable(
             iter([_REQUEST] * test_constants.STREAM_LENGTH),
             metadata=_INVOCATION_METADATA,
diff --git a/src/python/grpcio_tests/tests/unit/_reconnect_test.py b/src/python/grpcio_tests/tests/unit/_reconnect_test.py
index 8d4fadaa3da..d412533251c 100644
--- a/src/python/grpcio_tests/tests/unit/_reconnect_test.py
+++ b/src/python/grpcio_tests/tests/unit/_reconnect_test.py
@@ -52,10 +52,7 @@ class ReconnectTest(unittest.TestCase):
             server.add_insecure_port(addr)
             server.start()
         channel = grpc.insecure_channel(addr)
-        multi_callable = channel.unary_unary(
-            _UNARY_UNARY,
-            _registered_method=True,
-        )
+        multi_callable = channel.unary_unary(_UNARY_UNARY)
         self.assertEqual(_RESPONSE, multi_callable(_REQUEST))
         server.stop(None)
         # By default, the channel connectivity is checked every 5s
diff --git a/src/python/grpcio_tests/tests/unit/_resource_exhausted_test.py b/src/python/grpcio_tests/tests/unit/_resource_exhausted_test.py
index 93e72c84f07..3fc04f06a18 100644
--- a/src/python/grpcio_tests/tests/unit/_resource_exhausted_test.py
+++ b/src/python/grpcio_tests/tests/unit/_resource_exhausted_test.py
@@ -149,10 +149,7 @@ class ResourceExhaustedTest(unittest.TestCase):
         self._channel.close()
 
     def testUnaryUnary(self):
-        multi_callable = self._channel.unary_unary(
-            _UNARY_UNARY,
-            _registered_method=True,
-        )
+        multi_callable = self._channel.unary_unary(_UNARY_UNARY)
         futures = []
         for _ in range(test_constants.THREAD_CONCURRENCY):
             futures.append(multi_callable.future(_REQUEST))
@@ -181,10 +178,7 @@ class ResourceExhaustedTest(unittest.TestCase):
         self.assertEqual(_RESPONSE, multi_callable(_REQUEST))
 
     def testUnaryStream(self):
-        multi_callable = self._channel.unary_stream(
-            _UNARY_STREAM,
-            _registered_method=True,
-        )
+        multi_callable = self._channel.unary_stream(_UNARY_STREAM)
         calls = []
         for _ in range(test_constants.THREAD_CONCURRENCY):
             calls.append(multi_callable(_REQUEST))
@@ -211,10 +205,7 @@ class ResourceExhaustedTest(unittest.TestCase):
             self.assertEqual(_RESPONSE, response)
 
     def testStreamUnary(self):
-        multi_callable = self._channel.stream_unary(
-            _STREAM_UNARY,
-            _registered_method=True,
-        )
+        multi_callable = self._channel.stream_unary(_STREAM_UNARY)
         futures = []
         request = iter([_REQUEST] * test_constants.STREAM_LENGTH)
         for _ in range(test_constants.THREAD_CONCURRENCY):
@@ -245,10 +236,7 @@ class ResourceExhaustedTest(unittest.TestCase):
         self.assertEqual(_RESPONSE, multi_callable(request))
 
     def testStreamStream(self):
-        multi_callable = self._channel.stream_stream(
-            _STREAM_STREAM,
-            _registered_method=True,
-        )
+        multi_callable = self._channel.stream_stream(_STREAM_STREAM)
         calls = []
         request = iter([_REQUEST] * test_constants.STREAM_LENGTH)
         for _ in range(test_constants.THREAD_CONCURRENCY):
diff --git a/src/python/grpcio_tests/tests/unit/_rpc_test_helpers.py b/src/python/grpcio_tests/tests/unit/_rpc_test_helpers.py
index d85eb30c8e7..1027be1c677 100644
--- a/src/python/grpcio_tests/tests/unit/_rpc_test_helpers.py
+++ b/src/python/grpcio_tests/tests/unit/_rpc_test_helpers.py
@@ -277,10 +277,7 @@ class _GenericHandler(grpc.GenericRpcHandler):
 
 
 def unary_unary_multi_callable(channel):
-    return channel.unary_unary(
-        _UNARY_UNARY,
-        _registered_method=True,
-    )
+    return channel.unary_unary(_UNARY_UNARY)
 
 
 def unary_stream_multi_callable(channel):
@@ -288,7 +285,6 @@ def unary_stream_multi_callable(channel):
         _UNARY_STREAM,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
@@ -297,7 +293,6 @@ def unary_stream_non_blocking_multi_callable(channel):
         _UNARY_STREAM_NON_BLOCKING,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
@@ -306,22 +301,15 @@ def stream_unary_multi_callable(channel):
         _STREAM_UNARY,
         request_serializer=_SERIALIZE_REQUEST,
         response_deserializer=_DESERIALIZE_RESPONSE,
-        _registered_method=True,
     )
 
 
 def stream_stream_multi_callable(channel):
-    return channel.stream_stream(
-        _STREAM_STREAM,
-        _registered_method=True,
-    )
+    return channel.stream_stream(_STREAM_STREAM)
 
 
 def stream_stream_non_blocking_multi_callable(channel):
-    return channel.stream_stream(
-        _STREAM_STREAM_NON_BLOCKING,
-        _registered_method=True,
-    )
+    return channel.stream_stream(_STREAM_STREAM_NON_BLOCKING)
 
 
 class BaseRPCTest(object):
diff --git a/src/python/grpcio_tests/tests/unit/_server_shutdown_scenarios.py b/src/python/grpcio_tests/tests/unit/_server_shutdown_scenarios.py
index 34d51fd72ec..9190f108f7b 100644
--- a/src/python/grpcio_tests/tests/unit/_server_shutdown_scenarios.py
+++ b/src/python/grpcio_tests/tests/unit/_server_shutdown_scenarios.py
@@ -81,10 +81,7 @@ def run_test(args):
         thread.start()
         port = port_queue.get()
         channel = grpc.insecure_channel("localhost:%d" % port)
-        multi_callable = channel.unary_unary(
-            FORK_EXIT,
-            _registered_method=True,
-        )
+        multi_callable = channel.unary_unary(FORK_EXIT)
         result, call = multi_callable.with_call(REQUEST, wait_for_ready=True)
         os.wait()
     else:
diff --git a/src/python/grpcio_tests/tests/unit/_session_cache_test.py b/src/python/grpcio_tests/tests/unit/_session_cache_test.py
index e4bc64f7d11..acf671d1ca9 100644
--- a/src/python/grpcio_tests/tests/unit/_session_cache_test.py
+++ b/src/python/grpcio_tests/tests/unit/_session_cache_test.py
@@ -77,10 +77,7 @@ class SSLSessionCacheTest(unittest.TestCase):
         channel = grpc.secure_channel(
             "localhost:{}".format(port), channel_creds, options=channel_options
         )
-        response = channel.unary_unary(
-            _UNARY_UNARY,
-            _registered_method=True,
-        )(_REQUEST)
+        response = channel.unary_unary(_UNARY_UNARY)(_REQUEST)
         auth_data = pickle.loads(response)
         self.assertEqual(
             expect_ssl_session_reused,
diff --git a/src/python/grpcio_tests/tests/unit/_signal_client.py b/src/python/grpcio_tests/tests/unit/_signal_client.py
index 34c3da0c933..56563c20075 100644
--- a/src/python/grpcio_tests/tests/unit/_signal_client.py
+++ b/src/python/grpcio_tests/tests/unit/_signal_client.py
@@ -53,10 +53,7 @@ def main_unary(server_target):
     """Initiate a unary RPC to be interrupted by a SIGINT."""
     global per_process_rpc_future  # pylint: disable=global-statement
     with grpc.insecure_channel(server_target) as channel:
-        multicallable = channel.unary_unary(
-            UNARY_UNARY,
-            _registered_method=True,
-        )
+        multicallable = channel.unary_unary(UNARY_UNARY)
         signal.signal(signal.SIGINT, handle_sigint)
         per_process_rpc_future = multicallable.future(
             _MESSAGE, wait_for_ready=True
@@ -70,10 +67,9 @@ def main_streaming(server_target):
     global per_process_rpc_future  # pylint: disable=global-statement
     with grpc.insecure_channel(server_target) as channel:
         signal.signal(signal.SIGINT, handle_sigint)
-        per_process_rpc_future = channel.unary_stream(
-            UNARY_STREAM,
-            _registered_method=True,
-        )(_MESSAGE, wait_for_ready=True)
+        per_process_rpc_future = channel.unary_stream(UNARY_STREAM)(
+            _MESSAGE, wait_for_ready=True
+        )
         for result in per_process_rpc_future:
             pass
         assert False, _ASSERTION_MESSAGE
@@ -83,10 +79,7 @@ def main_unary_with_exception(server_target):
     """Initiate a unary RPC with a signal handler that will raise."""
     channel = grpc.insecure_channel(server_target)
     try:
-        channel.unary_unary(
-            UNARY_UNARY,
-            _registered_method=True,
-        )(_MESSAGE, wait_for_ready=True)
+        channel.unary_unary(UNARY_UNARY)(_MESSAGE, wait_for_ready=True)
     except KeyboardInterrupt:
         sys.stderr.write("Running signal handler.\n")
         sys.stderr.flush()
@@ -99,10 +92,9 @@ def main_streaming_with_exception(server_target):
     """Initiate a streaming RPC with a signal handler that will raise."""
     channel = grpc.insecure_channel(server_target)
     try:
-        for _ in channel.unary_stream(
-            UNARY_STREAM,
-            _registered_method=True,
-        )(_MESSAGE, wait_for_ready=True):
+        for _ in channel.unary_stream(UNARY_STREAM)(
+            _MESSAGE, wait_for_ready=True
+        ):
             pass
     except KeyboardInterrupt:
         sys.stderr.write("Running signal handler.\n")
diff --git a/src/python/grpcio_tests/tests/unit/_xds_credentials_test.py b/src/python/grpcio_tests/tests/unit/_xds_credentials_test.py
index 6d8b2b6a041..977d564888d 100644
--- a/src/python/grpcio_tests/tests/unit/_xds_credentials_test.py
+++ b/src/python/grpcio_tests/tests/unit/_xds_credentials_test.py
@@ -71,10 +71,9 @@ class XdsCredentialsTest(unittest.TestCase):
                 server_address, channel_creds, options=override_options
             ) as channel:
                 request = b"abc"
-                response = channel.unary_unary(
-                    "/test/method",
-                    _registered_method=True,
-                )(request, wait_for_ready=True)
+                response = channel.unary_unary("/test/method")(
+                    request, wait_for_ready=True
+                )
                 self.assertEqual(response, request)
 
     def test_xds_creds_fallback_insecure(self):
@@ -90,10 +89,9 @@ class XdsCredentialsTest(unittest.TestCase):
             channel_creds = grpc.xds_channel_credentials(channel_fallback_creds)
             with grpc.secure_channel(server_address, channel_creds) as channel:
                 request = b"abc"
-                response = channel.unary_unary(
-                    "/test/method",
-                    _registered_method=True,
-                )(request, wait_for_ready=True)
+                response = channel.unary_unary("/test/method")(
+                    request, wait_for_ready=True
+                )
                 self.assertEqual(response, request)
 
     def test_start_xds_server(self):
diff --git a/src/python/grpcio_tests/tests_gevent/unit/close_channel_test.py b/src/python/grpcio_tests/tests_gevent/unit/close_channel_test.py
index f09c47734e0..47fdb2c22e7 100644
--- a/src/python/grpcio_tests/tests_gevent/unit/close_channel_test.py
+++ b/src/python/grpcio_tests/tests_gevent/unit/close_channel_test.py
@@ -65,7 +65,6 @@ class CloseChannelTest(unittest.TestCase):
             _UNARY_CALL_METHOD_WITH_SLEEP,
             request_serializer=messages_pb2.SimpleRequest.SerializeToString,
             response_deserializer=messages_pb2.SimpleResponse.FromString,
-            _registered_method=True,
         )
         greenlet = group.spawn(self._run_client, UnaryCallWithSleep)
         # release loop so that greenlet can take control
@@ -79,7 +78,6 @@ class CloseChannelTest(unittest.TestCase):
             _UNARY_CALL_METHOD_WITH_SLEEP,
             request_serializer=messages_pb2.SimpleRequest.SerializeToString,
             response_deserializer=messages_pb2.SimpleResponse.FromString,
-            _registered_method=True,
         )
         greenlet = group.spawn(self._run_client, UnaryCallWithSleep)
         # release loop so that greenlet can take control
diff --git a/src/python/grpcio_tests/tests_py3_only/unit/_leak_test.py b/src/python/grpcio_tests/tests_py3_only/unit/_leak_test.py
index 06fa6466014..c917bd10521 100644
--- a/src/python/grpcio_tests/tests_py3_only/unit/_leak_test.py
+++ b/src/python/grpcio_tests/tests_py3_only/unit/_leak_test.py
@@ -68,10 +68,7 @@ def _start_a_test_server():
 
 def _perform_an_rpc(address):
     channel = grpc.insecure_channel(address)
-    multicallable = channel.unary_unary(
-        _TEST_METHOD,
-        _registered_method=True,
-    )
+    multicallable = channel.unary_unary(_TEST_METHOD)
     response = multicallable(_REQUEST)
     assert _REQUEST == response
 
diff --git a/src/python/grpcio_tests/tests_py3_only/unit/_simple_stubs_test.py b/src/python/grpcio_tests/tests_py3_only/unit/_simple_stubs_test.py
index adcc1299e9c..771097936f6 100644
--- a/src/python/grpcio_tests/tests_py3_only/unit/_simple_stubs_test.py
+++ b/src/python/grpcio_tests/tests_py3_only/unit/_simple_stubs_test.py
@@ -193,7 +193,6 @@ class SimpleStubsTest(unittest.TestCase):
                 _UNARY_UNARY,
                 channel_credentials=grpc.experimental.insecure_channel_credentials(),
                 timeout=None,
-                _registered_method=0,
             )
             self.assertEqual(_REQUEST, response)
 
@@ -206,7 +205,6 @@ class SimpleStubsTest(unittest.TestCase):
                 _UNARY_UNARY,
                 channel_credentials=grpc.local_channel_credentials(),
                 timeout=None,
-                _registered_method=0,
             )
             self.assertEqual(_REQUEST, response)
 
@@ -215,10 +213,7 @@ class SimpleStubsTest(unittest.TestCase):
             target = f"localhost:{port}"
             test_name = inspect.stack()[0][3]
             args = (_REQUEST, target, _UNARY_UNARY)
-            kwargs = {
-                "channel_credentials": grpc.local_channel_credentials(),
-                "_registered_method": True,
-            }
+            kwargs = {"channel_credentials": grpc.local_channel_credentials()}
 
             def _invoke(seed: str):
                 run_kwargs = dict(kwargs)
@@ -235,7 +230,6 @@ class SimpleStubsTest(unittest.TestCase):
                 target,
                 _UNARY_UNARY,
                 channel_credentials=grpc.local_channel_credentials(),
-                _registered_method=0,
             )
             self.assert_eventually(
                 lambda: grpc._simple_stubs.ChannelCache.get()._test_only_channel_count()
@@ -256,7 +250,6 @@ class SimpleStubsTest(unittest.TestCase):
                     _UNARY_UNARY,
                     options=options,
                     channel_credentials=grpc.local_channel_credentials(),
-                    _registered_method=0,
                 )
                 self.assert_eventually(
                     lambda: grpc._simple_stubs.ChannelCache.get()._test_only_channel_count()
@@ -272,7 +265,6 @@ class SimpleStubsTest(unittest.TestCase):
                 target,
                 _UNARY_STREAM,
                 channel_credentials=grpc.local_channel_credentials(),
-                _registered_method=0,
             ):
                 self.assertEqual(_REQUEST, response)
 
@@ -288,7 +280,6 @@ class SimpleStubsTest(unittest.TestCase):
                 target,
                 _STREAM_UNARY,
                 channel_credentials=grpc.local_channel_credentials(),
-                _registered_method=0,
             )
             self.assertEqual(_REQUEST, response)
 
@@ -304,7 +295,6 @@ class SimpleStubsTest(unittest.TestCase):
                 target,
                 _STREAM_STREAM,
                 channel_credentials=grpc.local_channel_credentials(),
-                _registered_method=0,
             ):
                 self.assertEqual(_REQUEST, response)
 
@@ -329,22 +319,14 @@ class SimpleStubsTest(unittest.TestCase):
             with _server(server_creds) as port:
                 target = f"localhost:{port}"
                 response = grpc.experimental.unary_unary(
-                    _REQUEST,
-                    target,
-                    _UNARY_UNARY,
-                    options=_property_options,
-                    _registered_method=0,
+                    _REQUEST, target, _UNARY_UNARY, options=_property_options
                 )
 
     def test_insecure_sugar(self):
         with _server(None) as port:
             target = f"localhost:{port}"
             response = grpc.experimental.unary_unary(
-                _REQUEST,
-                target,
-                _UNARY_UNARY,
-                insecure=True,
-                _registered_method=0,
+                _REQUEST, target, _UNARY_UNARY, insecure=True
             )
             self.assertEqual(_REQUEST, response)
 
@@ -358,24 +340,14 @@ class SimpleStubsTest(unittest.TestCase):
                     _UNARY_UNARY,
                     insecure=True,
                     channel_credentials=grpc.local_channel_credentials(),
-                    _registered_method=0,
                 )
 
     def test_default_wait_for_ready(self):
         addr, port, sock = get_socket()
         sock.close()
         target = f"{addr}:{port}"
-        (
-            channel,
-            unused_method_handle,
-        ) = grpc._simple_stubs.ChannelCache.get().get_channel(
-            target=target,
-            options=(),
-            channel_credentials=None,
-            insecure=True,
-            compression=None,
-            method=_UNARY_UNARY,
-            _registered_method=True,
+        channel = grpc._simple_stubs.ChannelCache.get().get_channel(
+            target, (), None, True, None
         )
         rpc_finished_event = threading.Event()
         rpc_failed_event = threading.Event()
@@ -404,12 +376,7 @@ class SimpleStubsTest(unittest.TestCase):
         def _send_rpc():
             try:
                 response = grpc.experimental.unary_unary(
-                    _REQUEST,
-                    target,
-                    _UNARY_UNARY,
-                    timeout=None,
-                    insecure=True,
-                    _registered_method=0,
+                    _REQUEST, target, _UNARY_UNARY, timeout=None, insecure=True
                 )
                 rpc_finished_event.set()
             except Exception as e:
@@ -432,7 +399,6 @@ class SimpleStubsTest(unittest.TestCase):
                     target,
                     _BLACK_HOLE,
                     insecure=True,
-                    _registered_method=0,
                     **invocation_args,
                 )
             self.assertEqual(