diff --git a/src/core/ext/filters/client_channel/client_channel.cc b/src/core/ext/filters/client_channel/client_channel.cc
index 2b7ad3facca..936d70b9591 100644
--- a/src/core/ext/filters/client_channel/client_channel.cc
+++ b/src/core/ext/filters/client_channel/client_channel.cc
@@ -1123,7 +1123,8 @@ static void pending_batches_add(grpc_call_element* elem,
     if (batch->send_trailing_metadata) {
       calld->pending_send_trailing_metadata = true;
     }
-    if (calld->bytes_buffered_for_retry > chand->per_rpc_retry_buffer_size) {
+    if (GPR_UNLIKELY(calld->bytes_buffered_for_retry >
+                     chand->per_rpc_retry_buffer_size)) {
       if (grpc_client_channel_trace.enabled()) {
         gpr_log(GPR_INFO,
                 "chand=%p calld=%p: exceeded retry buffer size, committing",
@@ -1470,7 +1471,7 @@ static bool maybe_retry(grpc_call_element* elem,
     }
   }
   // Check status.
-  if (status == GRPC_STATUS_OK) {
+  if (GPR_LIKELY(status == GRPC_STATUS_OK)) {
     if (calld->retry_throttle_data != nullptr) {
       calld->retry_throttle_data->RecordSuccess();
     }
@@ -1664,8 +1665,9 @@ static void recv_initial_metadata_ready(void* arg, grpc_error* error) {
   // the recv_trailing_metadata on_complete callback, then defer
   // propagating this callback back to the surface.  We can evaluate whether
   // to retry when recv_trailing_metadata comes back.
-  if ((batch_data->trailing_metadata_available || error != GRPC_ERROR_NONE) &&
-      !retry_state->completed_recv_trailing_metadata) {
+  if (GPR_UNLIKELY((batch_data->trailing_metadata_available ||
+                    error != GRPC_ERROR_NONE) &&
+                   !retry_state->completed_recv_trailing_metadata)) {
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO,
               "chand=%p calld=%p: deferring recv_initial_metadata_ready "
@@ -1753,8 +1755,9 @@ static void recv_message_ready(void* arg, grpc_error* error) {
   // the recv_trailing_metadata on_complete callback, then defer
   // propagating this callback back to the surface.  We can evaluate whether
   // to retry when recv_trailing_metadata comes back.
-  if ((batch_data->recv_message == nullptr || error != GRPC_ERROR_NONE) &&
-      !retry_state->completed_recv_trailing_metadata) {
+  if (GPR_UNLIKELY(
+          (batch_data->recv_message == nullptr || error != GRPC_ERROR_NONE) &&
+          !retry_state->completed_recv_trailing_metadata)) {
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO,
               "chand=%p calld=%p: deferring recv_message_ready (nullptr "
@@ -1867,7 +1870,8 @@ static void add_closures_for_deferred_recv_callbacks(
     closure_to_execute* closures, size_t* num_closures) {
   if (batch_data->batch.recv_trailing_metadata) {
     // Add closure for deferred recv_initial_metadata_ready.
-    if (retry_state->recv_initial_metadata_ready_deferred_batch != nullptr) {
+    if (GPR_UNLIKELY(retry_state->recv_initial_metadata_ready_deferred_batch !=
+                     nullptr)) {
       closure_to_execute* closure = &closures[(*num_closures)++];
       closure->closure = GRPC_CLOSURE_INIT(
           &batch_data->recv_initial_metadata_ready,
@@ -1879,7 +1883,8 @@ static void add_closures_for_deferred_recv_callbacks(
       retry_state->recv_initial_metadata_ready_deferred_batch = nullptr;
     }
     // Add closure for deferred recv_message_ready.
-    if (retry_state->recv_message_ready_deferred_batch != nullptr) {
+    if (GPR_UNLIKELY(retry_state->recv_message_ready_deferred_batch !=
+                     nullptr)) {
       closure_to_execute* closure = &closures[(*num_closures)++];
       closure->closure = GRPC_CLOSURE_INIT(
           &batch_data->recv_message_ready, invoke_recv_message_callback,
@@ -2048,7 +2053,7 @@ static void on_complete(void* arg, grpc_error* error) {
     // an error or (b) we receive status.
     grpc_status_code status = GRPC_STATUS_OK;
     grpc_mdelem* server_pushback_md = nullptr;
-    if (error != GRPC_ERROR_NONE) {  // Case (a).
+    if (GPR_UNLIKELY(error != GRPC_ERROR_NONE)) {  // Case (a).
       call_finished = true;
       grpc_error_get_status(error, calld->deadline, &status, nullptr, nullptr,
                             nullptr);
@@ -2224,13 +2229,13 @@ static void add_retriable_send_initial_metadata_op(
   grpc_metadata_batch_copy(&calld->send_initial_metadata,
                            &batch_data->send_initial_metadata,
                            batch_data->send_initial_metadata_storage);
-  if (batch_data->send_initial_metadata.idx.named.grpc_previous_rpc_attempts !=
-      nullptr) {
+  if (GPR_UNLIKELY(batch_data->send_initial_metadata.idx.named
+                       .grpc_previous_rpc_attempts != nullptr)) {
     grpc_metadata_batch_remove(
         &batch_data->send_initial_metadata,
         batch_data->send_initial_metadata.idx.named.grpc_previous_rpc_attempts);
   }
-  if (calld->num_attempts_completed > 0) {
+  if (GPR_UNLIKELY(calld->num_attempts_completed > 0)) {
     grpc_mdelem retry_md = grpc_mdelem_from_slices(
         GRPC_MDSTR_GRPC_PREVIOUS_RPC_ATTEMPTS,
         *retry_count_strings[calld->num_attempts_completed - 1]);
@@ -2480,7 +2485,8 @@ static void add_subchannel_batches_for_pending_batches(
       // If we previously completed a recv_trailing_metadata op
       // initiated by start_internal_recv_trailing_metadata(), use the
       // result of that instead of trying to re-start this op.
-      if (retry_state->recv_trailing_metadata_internal_batch != nullptr) {
+      if (GPR_UNLIKELY((retry_state->recv_trailing_metadata_internal_batch !=
+                        nullptr))) {
         // If the batch completed, then trigger the completion callback
         // directly, so that we return the previously returned results to
         // the application.  Otherwise, just unref the internally
@@ -2628,7 +2634,7 @@ static void create_subchannel_call(grpc_call_element* elem, grpc_error* error) {
     gpr_log(GPR_INFO, "chand=%p calld=%p: create subchannel_call=%p: error=%s",
             chand, calld, calld->subchannel_call, grpc_error_string(new_error));
   }
-  if (new_error != GRPC_ERROR_NONE) {
+  if (GPR_UNLIKELY(new_error != GRPC_ERROR_NONE)) {
     new_error = grpc_error_add_child(new_error, error);
     pending_batches_fail(elem, new_error, true /* yield_call_combiner */);
   } else {
@@ -2649,7 +2655,7 @@ static void pick_done(void* arg, grpc_error* error) {
   grpc_call_element* elem = static_cast<grpc_call_element*>(arg);
   channel_data* chand = static_cast<channel_data*>(elem->channel_data);
   call_data* calld = static_cast<call_data*>(elem->call_data);
-  if (calld->pick.connected_subchannel == nullptr) {
+  if (GPR_UNLIKELY(calld->pick.connected_subchannel == nullptr)) {
     // Failed to create subchannel.
     // If there was no error, this is an LB policy drop, in which case
     // we return an error; otherwise, we may retry.
@@ -2708,7 +2714,7 @@ static void pick_callback_cancel_locked(void* arg, grpc_error* error) {
   // Note: chand->lb_policy may have changed since we started our pick,
   // in which case we will be cancelling the pick on a policy other than
   // the one we started it on.  However, this will just be a no-op.
-  if (error != GRPC_ERROR_NONE && chand->lb_policy != nullptr) {
+  if (GPR_LIKELY(error != GRPC_ERROR_NONE && chand->lb_policy != nullptr)) {
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO, "chand=%p calld=%p: cancelling pick from LB policy %p",
               chand, calld, chand->lb_policy.get());
@@ -2780,7 +2786,7 @@ static bool pick_callback_start_locked(grpc_call_element* elem) {
             calld, chand->lb_policy.get());
   }
   // Only get service config data on the first attempt.
-  if (calld->num_attempts_completed == 0) {
+  if (GPR_LIKELY(calld->num_attempts_completed == 0)) {
     apply_service_config_to_call_locked(elem);
   }
   // If the application explicitly set wait_for_ready, use that.
@@ -2807,7 +2813,8 @@ static bool pick_callback_start_locked(grpc_call_element* elem) {
       calld->method_params != nullptr &&
       calld->method_params->wait_for_ready() !=
           ClientChannelMethodParams::WAIT_FOR_READY_UNSET;
-  if (!wait_for_ready_set_from_api && wait_for_ready_set_from_service_config) {
+  if (GPR_UNLIKELY(!wait_for_ready_set_from_api &&
+                   wait_for_ready_set_from_service_config)) {
     if (calld->method_params->wait_for_ready() ==
         ClientChannelMethodParams::WAIT_FOR_READY_TRUE) {
       send_initial_metadata_flags |= GRPC_INITIAL_METADATA_WAIT_FOR_READY;
@@ -2821,7 +2828,7 @@ static bool pick_callback_start_locked(grpc_call_element* elem) {
   calld->pick.on_complete = &calld->pick_closure;
   GRPC_CALL_STACK_REF(calld->owning_call, "pick_callback");
   const bool pick_done = chand->lb_policy->PickLocked(&calld->pick);
-  if (pick_done) {
+  if (GPR_LIKELY(pick_done)) {
     // Pick completed synchronously.
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO, "chand=%p calld=%p: pick completed synchronously",
@@ -2852,7 +2859,7 @@ static void pick_after_resolver_result_cancel_locked(void* arg,
                                                      grpc_error* error) {
   pick_after_resolver_result_args* args =
       static_cast<pick_after_resolver_result_args*>(arg);
-  if (args->finished) {
+  if (GPR_LIKELY(args->finished)) {
     gpr_free(args);
     return;
   }
@@ -2885,7 +2892,7 @@ static void pick_after_resolver_result_done_locked(void* arg,
                                                    grpc_error* error) {
   pick_after_resolver_result_args* args =
       static_cast<pick_after_resolver_result_args*>(arg);
-  if (args->finished) {
+  if (GPR_UNLIKELY(args->finished)) {
     /* cancelled, do nothing */
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO, "call cancelled before resolver result");
@@ -2897,13 +2904,13 @@ static void pick_after_resolver_result_done_locked(void* arg,
   grpc_call_element* elem = args->elem;
   channel_data* chand = static_cast<channel_data*>(elem->channel_data);
   call_data* calld = static_cast<call_data*>(elem->call_data);
-  if (error != GRPC_ERROR_NONE) {
+  if (GPR_UNLIKELY(error != GRPC_ERROR_NONE)) {
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO, "chand=%p calld=%p: resolver failed to return data",
               chand, calld);
     }
     async_pick_done_locked(elem, GRPC_ERROR_REF(error));
-  } else if (chand->resolver == nullptr) {
+  } else if (GPR_UNLIKELY(chand->resolver == nullptr)) {
     // Shutting down.
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO, "chand=%p calld=%p: resolver disconnected", chand,
@@ -2911,7 +2918,7 @@ static void pick_after_resolver_result_done_locked(void* arg,
     }
     async_pick_done_locked(
         elem, GRPC_ERROR_CREATE_FROM_STATIC_STRING("Disconnected"));
-  } else if (chand->lb_policy == nullptr) {
+  } else if (GPR_UNLIKELY(chand->lb_policy == nullptr)) {
     // Transient resolver failure.
     // If call has wait_for_ready=true, try again; otherwise, fail.
     uint32_t send_initial_metadata_flags =
@@ -2946,7 +2953,7 @@ static void pick_after_resolver_result_done_locked(void* arg,
       gpr_log(GPR_INFO, "chand=%p calld=%p: resolver returned, doing pick",
               chand, calld);
     }
-    if (pick_callback_start_locked(elem)) {
+    if (GPR_LIKELY(pick_callback_start_locked(elem))) {
       // Even if the LB policy returns a result synchronously, we have
       // already added our polling entity to chand->interested_parties
       // in order to wait for the resolver result, so we need to
@@ -2985,21 +2992,21 @@ static void start_pick_locked(void* arg, grpc_error* ignored) {
   channel_data* chand = static_cast<channel_data*>(elem->channel_data);
   GPR_ASSERT(calld->pick.connected_subchannel == nullptr);
   GPR_ASSERT(calld->subchannel_call == nullptr);
-  if (chand->lb_policy != nullptr) {
+  if (GPR_LIKELY(chand->lb_policy != nullptr)) {
     // We already have an LB policy, so ask it for a pick.
-    if (pick_callback_start_locked(elem)) {
+    if (GPR_LIKELY(pick_callback_start_locked(elem))) {
       // Pick completed synchronously.
       pick_done_locked(elem, GRPC_ERROR_NONE);
       return;
     }
   } else {
     // We do not yet have an LB policy, so wait for a resolver result.
-    if (chand->resolver == nullptr) {
+    if (GPR_UNLIKELY(chand->resolver == nullptr)) {
       pick_done_locked(elem,
                        GRPC_ERROR_CREATE_FROM_STATIC_STRING("Disconnected"));
       return;
     }
-    if (!chand->started_resolving) {
+    if (GPR_UNLIKELY(!chand->started_resolving)) {
       start_resolving_locked(chand);
     }
     pick_after_resolver_result_start_locked(elem);
@@ -3022,11 +3029,11 @@ static void cc_start_transport_stream_op_batch(
   GPR_TIMER_SCOPE("cc_start_transport_stream_op_batch", 0);
   call_data* calld = static_cast<call_data*>(elem->call_data);
   channel_data* chand = static_cast<channel_data*>(elem->channel_data);
-  if (chand->deadline_checking_enabled) {
+  if (GPR_LIKELY(chand->deadline_checking_enabled)) {
     grpc_deadline_state_client_start_transport_stream_op_batch(elem, batch);
   }
   // If we've previously been cancelled, immediately fail any new batches.
-  if (calld->cancel_error != GRPC_ERROR_NONE) {
+  if (GPR_UNLIKELY(calld->cancel_error != GRPC_ERROR_NONE)) {
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO, "chand=%p calld=%p: failing batch with error: %s",
               chand, calld, grpc_error_string(calld->cancel_error));
@@ -3037,7 +3044,7 @@ static void cc_start_transport_stream_op_batch(
     return;
   }
   // Handle cancellation.
-  if (batch->cancel_stream) {
+  if (GPR_UNLIKELY(batch->cancel_stream)) {
     // Stash a copy of cancel_error in our call data, so that we can use
     // it for subsequent operations.  This ensures that if the call is
     // cancelled before any batches are passed down (e.g., if the deadline
@@ -3083,7 +3090,7 @@ static void cc_start_transport_stream_op_batch(
   // We do not yet have a subchannel call.
   // For batches containing a send_initial_metadata op, enter the channel
   // combiner to start a pick.
-  if (batch->send_initial_metadata) {
+  if (GPR_LIKELY(batch->send_initial_metadata)) {
     if (grpc_client_channel_trace.enabled()) {
       gpr_log(GPR_INFO, "chand=%p calld=%p: entering client_channel combiner",
               chand, calld);
@@ -3116,7 +3123,7 @@ static grpc_error* cc_init_call_elem(grpc_call_element* elem,
   calld->arena = args->arena;
   calld->owning_call = args->call_stack;
   calld->call_combiner = args->call_combiner;
-  if (chand->deadline_checking_enabled) {
+  if (GPR_LIKELY(chand->deadline_checking_enabled)) {
     grpc_deadline_state_init(elem, args->call_stack, args->call_combiner,
                              calld->deadline);
   }
@@ -3131,14 +3138,14 @@ static void cc_destroy_call_elem(grpc_call_element* elem,
                                  grpc_closure* then_schedule_closure) {
   call_data* calld = static_cast<call_data*>(elem->call_data);
   channel_data* chand = static_cast<channel_data*>(elem->channel_data);
-  if (chand->deadline_checking_enabled) {
+  if (GPR_LIKELY(chand->deadline_checking_enabled)) {
     grpc_deadline_state_destroy(elem);
   }
   grpc_slice_unref_internal(calld->path);
   calld->retry_throttle_data.reset();
   calld->method_params.reset();
   GRPC_ERROR_UNREF(calld->cancel_error);
-  if (calld->subchannel_call != nullptr) {
+  if (GPR_LIKELY(calld->subchannel_call != nullptr)) {
     grpc_subchannel_call_set_cleanup_closure(calld->subchannel_call,
                                              then_schedule_closure);
     then_schedule_closure = nullptr;
@@ -3148,7 +3155,7 @@ static void cc_destroy_call_elem(grpc_call_element* elem,
   for (size_t i = 0; i < GPR_ARRAY_SIZE(calld->pending_batches); ++i) {
     GPR_ASSERT(calld->pending_batches[i].batch == nullptr);
   }
-  if (calld->pick.connected_subchannel != nullptr) {
+  if (GPR_LIKELY(calld->pick.connected_subchannel != nullptr)) {
     calld->pick.connected_subchannel.reset();
   }
   for (size_t i = 0; i < GRPC_CONTEXT_COUNT; ++i) {