diff --git a/tools/release/verify_python_release.py b/tools/release/verify_python_release.py
new file mode 100644
index 00000000000..af2892b61a5
--- /dev/null
+++ b/tools/release/verify_python_release.py
@@ -0,0 +1,116 @@
+#!/usr/bin/env python3
+
+#Copyright 2019 gRPC authors.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+"""Verifies that all gRPC Python artifacts have been successfully published.
+
+This script is intended to be run from a directory containing the artifacts
+that have been uploaded and only the artifacts that have been uploaded. We use
+PyPI's JSON API to verify that the proper filenames and checksums are present.
+
+Note that PyPI may take several minutes to update its metadata. Don't have a
+heart attack immediately.
+
+This sanity check is a good first step, but ideally, we would automate the
+entire release process.
+"""
+
+import argparse
+import collections
+import hashlib
+import os
+import requests
+import sys
+
+_DEFAULT_PACKAGES = [
+    "grpcio",
+    "grpcio-tools",
+    "grpcio-status",
+    "grpcio-health-checking",
+    "grpcio-reflection",
+    "grpcio-channelz",
+    "grpcio-testing",
+]
+
+Artifact = collections.namedtuple("Artifact", ("filename", "checksum"))
+
+
+def _get_md5_checksum(filename):
+    """Calculate the md5sum for a file."""
+    hash_md5 = hashlib.md5()
+    with open(filename, 'rb') as f:
+        for chunk in iter(lambda: f.read(4096), b""):
+            hash_md5.update(chunk)
+        return hash_md5.hexdigest()
+
+
+def _get_local_artifacts():
+    """Get a set of artifacts representing all files in the cwd."""
+    return set(
+        Artifact(f, _get_md5_checksum(f)) for f in os.listdir(os.getcwd()))
+
+
+def _get_remote_artifacts_for_package(package, version):
+    """Get a list of artifacts based on PyPi's json metadata.
+
+    Note that this data will not updated immediately after upload. In my
+    experience, it has taken a minute on average to be fresh.
+    """
+    artifacts = set()
+    payload = requests.get("https://pypi.org/pypi/{}/{}/json".format(
+        package, version)).json()
+    for download_info in payload['releases'][version]:
+        artifacts.add(
+            Artifact(download_info['filename'], download_info['md5_digest']))
+    return artifacts
+
+
+def _get_remote_artifacts_for_packages(packages, version):
+    artifacts = set()
+    for package in packages:
+        artifacts |= _get_remote_artifacts_for_package(package, version)
+    return artifacts
+
+
+def _verify_release(version, packages):
+    """Compare the local artifacts to the packages uploaded to PyPI."""
+    local_artifacts = _get_local_artifacts()
+    remote_artifacts = _get_remote_artifacts_for_packages(packages, version)
+    if local_artifacts != remote_artifacts:
+        local_but_not_remote = local_artifacts - remote_artifacts
+        remote_but_not_local = remote_artifacts - local_artifacts
+        if local_but_not_remote:
+            print("The following artifacts exist locally but not remotely.")
+            for artifact in local_but_not_remote:
+                print(artifact)
+        if remote_but_not_local:
+            print("The following artifacts exist remotely but not locally.")
+            for artifact in remote_but_not_local:
+                print(artifact)
+        sys.exit(1)
+    print("Release verified successfully.")
+
+
+if __name__ == "__main__":
+    parser = argparse.ArgumentParser(
+        "Verify a release. Run this from a directory containing only the"
+        "artifacts to be uploaded. Note that PyPI may take several minutes"
+        "after the upload to reflect the proper metadata."
+    )
+    parser.add_argument("version")
+    parser.add_argument(
+        "packages", nargs='*', type=str, default=_DEFAULT_PACKAGES)
+    args = parser.parse_args()
+    _verify_release(args.version, args.packages)