diff --git a/CMakeLists.txt b/CMakeLists.txt
index c6e292b0373..787db67baa0 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -26337,6 +26337,7 @@ add_executable(rls_end2end_test
   ${_gRPC_PROTO_GENS_DIR}/src/proto/grpc/testing/xds/v3/orca_load_report.grpc.pb.cc
   ${_gRPC_PROTO_GENS_DIR}/src/proto/grpc/testing/xds/v3/orca_load_report.pb.h
   ${_gRPC_PROTO_GENS_DIR}/src/proto/grpc/testing/xds/v3/orca_load_report.grpc.pb.h
+  test/core/event_engine/event_engine_test_utils.cc
   test/core/test_util/fake_stats_plugin.cc
   test/core/test_util/test_lb_policies.cc
   test/cpp/end2end/rls_end2end_test.cc
diff --git a/build_autogenerated.yaml b/build_autogenerated.yaml
index 7e4f95f2932..dd845a6d959 100644
--- a/build_autogenerated.yaml
+++ b/build_autogenerated.yaml
@@ -17596,6 +17596,7 @@ targets:
   run: false
   language: c++
   headers:
+  - test/core/event_engine/event_engine_test_utils.h
   - test/core/test_util/fake_stats_plugin.h
   - test/core/test_util/test_lb_policies.h
   - test/cpp/end2end/counted_service.h
@@ -17608,6 +17609,7 @@ targets:
   - src/proto/grpc/testing/echo_messages.proto
   - src/proto/grpc/testing/simple_messages.proto
   - src/proto/grpc/testing/xds/v3/orca_load_report.proto
+  - test/core/event_engine/event_engine_test_utils.cc
   - test/core/test_util/fake_stats_plugin.cc
   - test/core/test_util/test_lb_policies.cc
   - test/cpp/end2end/rls_end2end_test.cc
diff --git a/test/core/event_engine/event_engine_test_utils.cc b/test/core/event_engine/event_engine_test_utils.cc
index cc036ad5d3b..32ab6ac5276 100644
--- a/test/core/event_engine/event_engine_test_utils.cc
+++ b/test/core/event_engine/event_engine_test_utils.cc
@@ -41,6 +41,7 @@
 #include "src/core/lib/gprpp/notification.h"
 #include "src/core/lib/gprpp/time.h"
 #include "src/core/lib/resource_quota/memory_quota.h"
+#include "test/core/test_util/build.h"
 
 // IWYU pragma: no_include <sys/socket.h>
 
@@ -77,7 +78,10 @@ std::string GetNextSendMessage() {
 }
 
 void WaitForSingleOwner(std::shared_ptr<EventEngine> engine) {
+  int n = 0;
   while (engine.use_count() > 1) {
+    ++n;
+    if (n % 100 == 0) AsanAssertNoLeaks();
     GRPC_LOG_EVERY_N_SEC(2, GPR_INFO, "engine.use_count() = %ld",
                          engine.use_count());
     absl::SleepFor(absl::Milliseconds(100));
diff --git a/test/core/test_util/build.cc b/test/core/test_util/build.cc
index 04d39e9574d..36510696681 100644
--- a/test/core/test_util/build.cc
+++ b/test/core/test_util/build.cc
@@ -12,62 +12,78 @@
 // See the License for the specific language governing permissions and
 // limitations under the License.
 
-bool BuiltUnderValgrind() {
-#ifdef RUNNING_ON_VALGRIND
-  return true;
-#else
-  return false;
-#endif
-}
-
-bool BuiltUnderTsan() {
+// Define GRPC_BUILD_HAS_ASAN as 1 or 0 depending on if we're building under
+// ASAN.
 #if defined(__has_feature)
-#if __has_feature(thread_sanitizer)
-  return true;
+#if __has_feature(address_sanitizer)
+#define GRPC_BUILD_HAS_ASAN 1
 #else
-  return false;
+#define GRPC_BUILD_HAS_ASAN 0
 #endif
 #else
-#ifdef THREAD_SANITIZER
-  return true;
+#ifdef ADDRESS_SANITIZER
+#define GRPC_BUILD_HAS_ASAN 1
 #else
-  return false;
+#define GRPC_BUILD_HAS_ASAN 0
 #endif
 #endif
-}
 
-bool BuiltUnderAsan() {
+// Define GRPC_BUILD_HAS_TSAN as 1 or 0 depending on if we're building under
+// TSAN.
 #if defined(__has_feature)
-#if __has_feature(address_sanitizer)
-  return true;
+#if __has_feature(thread_sanitizer)
+#define GRPC_BUILD_HAS_TSAN 1
 #else
-  return false;
+#define GRPC_BUILD_HAS_TSAN 0
 #endif
 #else
-#ifdef ADDRESS_SANITIZER
-  return true;
+#ifdef THREAD_SANITIZER
+#define GRPC_BUILD_HAS_TSAN 1
 #else
-  return false;
+#define GRPC_BUILD_HAS_TSAN 0
 #endif
 #endif
-}
 
-bool BuiltUnderMsan() {
+// Define GRPC_BUILD_HAS_MSAN as 1 or 0 depending on if we're building under
+// MSAN.
 #if defined(__has_feature)
 #if __has_feature(memory_sanitizer)
-  return true;
+#define GRPC_BUILD_HAS_MSAN 1
 #else
-  return false;
+#define GRPC_BUILD_HAS_MSAN 0
 #endif
 #else
 #ifdef MEMORY_SANITIZER
+#define GRPC_BUILD_HAS_MSAN 1
+#else
+#define GRPC_BUILD_HAS_MSAN 0
+#endif
+#endif
+
+#if GRPC_BUILD_HAS_ASAN
+#include <sanitizer/lsan_interface.h>
+#endif
+
+bool BuiltUnderValgrind() {
+#ifdef RUNNING_ON_VALGRIND
   return true;
 #else
   return false;
 #endif
+}
+
+bool BuiltUnderTsan() { return GRPC_BUILD_HAS_TSAN != 0; }
+
+bool BuiltUnderAsan() { return GRPC_BUILD_HAS_ASAN != 0; }
+
+void AsanAssertNoLeaks() {
+#if GRPC_BUILD_HAS_ASAN
+  __lsan_do_leak_check();
 #endif
 }
 
+bool BuiltUnderMsan() { return GRPC_BUILD_HAS_MSAN != 0; }
+
 bool BuiltUnderUbsan() {
 #ifdef GRPC_UBSAN
   return true;
diff --git a/test/core/test_util/build.h b/test/core/test_util/build.h
index 20bc21954ff..8574dfe8d3c 100644
--- a/test/core/test_util/build.h
+++ b/test/core/test_util/build.h
@@ -30,4 +30,7 @@ bool BuiltUnderMsan();
 // Returns whether this is built under UndefinedBehaviorSanitizer
 bool BuiltUnderUbsan();
 
+// Force a leak check if built under ASAN. If there are leaks, crash.
+void AsanAssertNoLeaks();
+
 #endif  // GRPC_TEST_CORE_TEST_UTIL_BUILD_H
diff --git a/test/cpp/end2end/BUILD b/test/cpp/end2end/BUILD
index 4e0b8ed3e55..3e01fe662f9 100644
--- a/test/cpp/end2end/BUILD
+++ b/test/cpp/end2end/BUILD
@@ -584,6 +584,7 @@ grpc_cc_test(
         "//src/proto/grpc/testing:echo_messages_proto",
         "//src/proto/grpc/testing:echo_proto",
         "//src/proto/grpc/testing/duplicate:echo_duplicate_proto",
+        "//test/core/event_engine:event_engine_test_utils",
         "//test/core/test_util:fake_stats_plugin",
         "//test/core/test_util:grpc_test_util",
         "//test/core/test_util:test_lb_policies",
diff --git a/test/cpp/end2end/rls_end2end_test.cc b/test/cpp/end2end/rls_end2end_test.cc
index 5eb5e41ac3e..189c4c2d34c 100644
--- a/test/cpp/end2end/rls_end2end_test.cc
+++ b/test/cpp/end2end/rls_end2end_test.cc
@@ -58,6 +58,7 @@
 #include "src/proto/grpc/lookup/v1/rls.grpc.pb.h"
 #include "src/proto/grpc/lookup/v1/rls.pb.h"
 #include "src/proto/grpc/testing/echo.grpc.pb.h"
+#include "test/core/event_engine/event_engine_test_utils.h"
 #include "test/core/test_util/fake_stats_plugin.h"
 #include "test/core/test_util/port.h"
 #include "test/core/test_util/resolve_localhost_ip46.h"
@@ -175,6 +176,8 @@ class RlsEnd2endTest : public ::testing::Test {
 
   static void TearDownTestSuite() {
     grpc_shutdown_blocking();
+    WaitForSingleOwner(
+        grpc_event_engine::experimental::GetDefaultEventEngine());
     grpc_core::CoreConfiguration::Reset();
   }