diff --git a/tools/interop_matrix/client_matrix.py b/tools/interop_matrix/client_matrix.py
index 05e5c7dd76c..790cd2df527 100644
--- a/tools/interop_matrix/client_matrix.py
+++ b/tools/interop_matrix/client_matrix.py
@@ -288,6 +288,7 @@ LANG_RELEASE_MATRIX = {
             ('v1.46.0', ReleaseInfo()),
             ('v1.47.0', ReleaseInfo()),
             ('v1.48.1', ReleaseInfo()),
+            ('v1.49.0', ReleaseInfo()),
         ]),
     'python':
         OrderedDict(