diff --git a/test/core/end2end/gen_build_yaml.py b/test/core/end2end/gen_build_yaml.py
index cffe5995bcd..3e10ad580fc 100755
--- a/test/core/end2end/gen_build_yaml.py
+++ b/test/core/end2end/gen_build_yaml.py
@@ -39,9 +39,9 @@ import hashlib
 
 FixtureOptions = collections.namedtuple(
     'FixtureOptions',
-    'fullstack includes_proxy dns_resolver secure platforms ci_mac tracing')
+    'fullstack includes_proxy dns_resolver secure platforms ci_mac tracing exclude_configs')
 default_unsecure_fixture_options = FixtureOptions(
-    True, False, True, False, ['windows', 'linux', 'mac', 'posix'], True, False)
+    True, False, True, False, ['windows', 'linux', 'mac', 'posix'], True, False, [])
 socketpair_unsecure_fixture_options = default_unsecure_fixture_options._replace(fullstack=False, dns_resolver=False)
 default_secure_fixture_options = default_unsecure_fixture_options._replace(secure=True)
 uds_fixture_options = default_unsecure_fixture_options._replace(dns_resolver=False, platforms=['linux', 'mac', 'posix'])
@@ -60,7 +60,7 @@ END2END_FIXTURES = {
     'h2_proxy': default_unsecure_fixture_options._replace(includes_proxy=True,
                                                           ci_mac=False),
     'h2_sockpair_1byte': socketpair_unsecure_fixture_options._replace(
-        ci_mac=False),
+        ci_mac=False, exclude_configs=['msan']),
     'h2_sockpair': socketpair_unsecure_fixture_options._replace(ci_mac=False),
     'h2_sockpair+trace': socketpair_unsecure_fixture_options._replace(
         ci_mac=False, tracing=True),
@@ -246,7 +246,7 @@ def main():
           {
               'name': '%s_nosec_test' % f,
               'args': [t],
-              'exclude_configs': [],
+              'exclude_configs': END2END_FIXTURES[f].exclude_configs,
               'platforms': END2END_FIXTURES[f].platforms,
               'ci_platforms': (END2END_FIXTURES[f].platforms
                                if END2END_FIXTURES[f].ci_mac else without(
diff --git a/tools/run_tests/tests.json b/tools/run_tests/tests.json
index cf1154426f4..4cc407e39ed 100644
--- a/tools/run_tests/tests.json
+++ b/tools/run_tests/tests.json
@@ -21531,7 +21531,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21552,7 +21554,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21573,7 +21577,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21594,7 +21600,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21615,7 +21623,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21636,7 +21646,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21657,7 +21669,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21678,7 +21692,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21699,7 +21715,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21720,7 +21738,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21741,7 +21761,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21762,7 +21784,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21783,7 +21807,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21804,7 +21830,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21825,7 +21853,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21846,7 +21876,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21867,7 +21899,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21888,7 +21922,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21909,7 +21945,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21930,7 +21968,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21951,7 +21991,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21972,7 +22014,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -21993,7 +22037,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22014,7 +22060,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22035,7 +22083,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22056,7 +22106,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22077,7 +22129,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22098,7 +22152,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22119,7 +22175,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22140,7 +22198,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22161,7 +22221,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test", 
@@ -22182,7 +22244,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_nosec_test",