diff --git a/BUILD b/BUILD
index a3330873dc6..eb361ee9bb8 100644
--- a/BUILD
+++ b/BUILD
@@ -229,6 +229,7 @@ GRPC_PUBLIC_EVENT_ENGINE_HDRS = [
     "include/grpc/event_engine/internal/memory_allocator_impl.h",
     "include/grpc/event_engine/slice.h",
     "include/grpc/event_engine/slice_buffer.h",
+    "include/grpc/event_engine/internal/slice_cast.h",
 ]
 
 GRPCXX_SRCS = [
@@ -1423,6 +1424,7 @@ grpc_cc_library(
         "//src/core:resource_quota_trace",
         "//src/core:slice",
         "//src/core:slice_buffer",
+        "//src/core:slice_cast",
         "//src/core:slice_refcount",
         "//src/core:socket_mutator",
         "//src/core:stats_data",
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 9c057e3e477..ee75debc48c 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -2463,6 +2463,7 @@ foreach(_hdr
   include/grpc/event_engine/endpoint_config.h
   include/grpc/event_engine/event_engine.h
   include/grpc/event_engine/internal/memory_allocator_impl.h
+  include/grpc/event_engine/internal/slice_cast.h
   include/grpc/event_engine/memory_allocator.h
   include/grpc/event_engine/memory_request.h
   include/grpc/event_engine/port.h
@@ -3073,6 +3074,7 @@ foreach(_hdr
   include/grpc/event_engine/endpoint_config.h
   include/grpc/event_engine/event_engine.h
   include/grpc/event_engine/internal/memory_allocator_impl.h
+  include/grpc/event_engine/internal/slice_cast.h
   include/grpc/event_engine/memory_allocator.h
   include/grpc/event_engine/memory_request.h
   include/grpc/event_engine/port.h
@@ -4539,6 +4541,7 @@ foreach(_hdr
   include/grpc/event_engine/endpoint_config.h
   include/grpc/event_engine/event_engine.h
   include/grpc/event_engine/internal/memory_allocator_impl.h
+  include/grpc/event_engine/internal/slice_cast.h
   include/grpc/event_engine/memory_allocator.h
   include/grpc/event_engine/memory_request.h
   include/grpc/event_engine/port.h
diff --git a/Makefile b/Makefile
index db1924586c2..95b48a4ed49 100644
--- a/Makefile
+++ b/Makefile
@@ -1680,6 +1680,7 @@ PUBLIC_HEADERS_C += \
     include/grpc/event_engine/endpoint_config.h \
     include/grpc/event_engine/event_engine.h \
     include/grpc/event_engine/internal/memory_allocator_impl.h \
+    include/grpc/event_engine/internal/slice_cast.h \
     include/grpc/event_engine/memory_allocator.h \
     include/grpc/event_engine/memory_request.h \
     include/grpc/event_engine/port.h \
@@ -2150,6 +2151,7 @@ PUBLIC_HEADERS_C += \
     include/grpc/event_engine/endpoint_config.h \
     include/grpc/event_engine/event_engine.h \
     include/grpc/event_engine/internal/memory_allocator_impl.h \
+    include/grpc/event_engine/internal/slice_cast.h \
     include/grpc/event_engine/memory_allocator.h \
     include/grpc/event_engine/memory_request.h \
     include/grpc/event_engine/port.h \
diff --git a/build_autogenerated.yaml b/build_autogenerated.yaml
index 4f0b28f7a5d..862322a421e 100644
--- a/build_autogenerated.yaml
+++ b/build_autogenerated.yaml
@@ -260,6 +260,7 @@ libs:
   - include/grpc/event_engine/endpoint_config.h
   - include/grpc/event_engine/event_engine.h
   - include/grpc/event_engine/internal/memory_allocator_impl.h
+  - include/grpc/event_engine/internal/slice_cast.h
   - include/grpc/event_engine/memory_allocator.h
   - include/grpc/event_engine/memory_request.h
   - include/grpc/event_engine/port.h
@@ -1859,6 +1860,7 @@ libs:
   - include/grpc/event_engine/endpoint_config.h
   - include/grpc/event_engine/event_engine.h
   - include/grpc/event_engine/internal/memory_allocator_impl.h
+  - include/grpc/event_engine/internal/slice_cast.h
   - include/grpc/event_engine/memory_allocator.h
   - include/grpc/event_engine/memory_request.h
   - include/grpc/event_engine/port.h
@@ -3383,6 +3385,7 @@ libs:
   - include/grpc/event_engine/endpoint_config.h
   - include/grpc/event_engine/event_engine.h
   - include/grpc/event_engine/internal/memory_allocator_impl.h
+  - include/grpc/event_engine/internal/slice_cast.h
   - include/grpc/event_engine/memory_allocator.h
   - include/grpc/event_engine/memory_request.h
   - include/grpc/event_engine/port.h
diff --git a/gRPC-Core.podspec b/gRPC-Core.podspec
index d08d6a6dd29..4a55c0e1cf9 100644
--- a/gRPC-Core.podspec
+++ b/gRPC-Core.podspec
@@ -111,6 +111,7 @@ Pod::Spec.new do |s|
                       'include/grpc/event_engine/endpoint_config.h',
                       'include/grpc/event_engine/event_engine.h',
                       'include/grpc/event_engine/internal/memory_allocator_impl.h',
+                      'include/grpc/event_engine/internal/slice_cast.h',
                       'include/grpc/event_engine/memory_allocator.h',
                       'include/grpc/event_engine/memory_request.h',
                       'include/grpc/event_engine/port.h',
diff --git a/grpc.gemspec b/grpc.gemspec
index 255cae8c491..4d12ccdbe37 100644
--- a/grpc.gemspec
+++ b/grpc.gemspec
@@ -54,6 +54,7 @@ Gem::Specification.new do |s|
   s.files += %w( include/grpc/event_engine/endpoint_config.h )
   s.files += %w( include/grpc/event_engine/event_engine.h )
   s.files += %w( include/grpc/event_engine/internal/memory_allocator_impl.h )
+  s.files += %w( include/grpc/event_engine/internal/slice_cast.h )
   s.files += %w( include/grpc/event_engine/memory_allocator.h )
   s.files += %w( include/grpc/event_engine/memory_request.h )
   s.files += %w( include/grpc/event_engine/port.h )
diff --git a/include/grpc/event_engine/internal/slice_cast.h b/include/grpc/event_engine/internal/slice_cast.h
new file mode 100644
index 00000000000..ab9db95f937
--- /dev/null
+++ b/include/grpc/event_engine/internal/slice_cast.h
@@ -0,0 +1,55 @@
+// Copyright 2022 gRPC authors.
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+#ifndef GRPC_EVENT_ENGINE_INTERNAL_SLICE_CAST_H
+#define GRPC_EVENT_ENGINE_INTERNAL_SLICE_CAST_H
+
+namespace grpc_event_engine {
+namespace experimental {
+namespace internal {
+
+// Opt-in trait class for slice conversions.
+// Declare a specialization of this class for any types that are compatible
+// with `SliceCast`. Both ways need to be declared (i.e. if
+// ConstRefSliceCastable<A,B> exists, you should declare
+// ConstRefSliceCastable<B,A> too).
+// The type has no members, it's just the existance of the specialization that
+// unlocks SliceCast usage for a type pair.
+template <typename Result, typename T>
+struct ConstRefSliceCastable;
+
+// This is strictly too wide, but consider all types to be SliceCast-able to
+// themselves.
+// Unfortunately this allows `const int& x = SliceCast<int>(x);` which is kind
+// of bogus.
+template <typename A>
+struct ConstRefSliceCastable<A, A> {};
+
+// Cast to `const Result&` from `const T&` without any runtime checks.
+// This is only valid if `sizeof(Result) == sizeof(T)`, and if `Result`, `T` are
+// opted in as compatible via `ConstRefSliceCastable`.
+template <typename Result, typename T>
+const Result& SliceCast(const T& value, ConstRefSliceCastable<Result, T> = {}) {
+  // Insist upon sizes being equal to catch mismatches.
+  // We assume if sizes are opted in and sizes are equal then yes, these two
+  // types are expected to be layout compatible and actually appear to be.
+  static_assert(sizeof(Result) == sizeof(T), "size mismatch");
+  return reinterpret_cast<const Result&>(value);
+}
+
+}  // namespace internal
+}  // namespace experimental
+}  // namespace grpc_event_engine
+
+#endif  // GRPC_EVENT_ENGINE_INTERNAL_SLICE_CAST_H
diff --git a/include/grpc/event_engine/slice.h b/include/grpc/event_engine/slice.h
index 515cdfdcfd9..1e296a21876 100644
--- a/include/grpc/event_engine/slice.h
+++ b/include/grpc/event_engine/slice.h
@@ -25,6 +25,7 @@
 
 #include "absl/strings/string_view.h"
 
+#include <grpc/event_engine/internal/slice_cast.h>
 #include <grpc/slice.h>
 #include <grpc/support/log.h>
 
@@ -212,8 +213,9 @@ class MutableSlice : public slice_detail::BaseSlice,
   uint8_t& operator[](size_t i) { return mutable_data()[i]; }
 };
 
-class Slice : public slice_detail::BaseSlice,
-              public slice_detail::CopyConstructors<Slice> {
+class GPR_MSVC_EMPTY_BASE_CLASS_WORKAROUND Slice
+    : public slice_detail::BaseSlice,
+      public slice_detail::CopyConstructors<Slice> {
  public:
   Slice() = default;
   ~Slice();
@@ -280,6 +282,13 @@ class Slice : public slice_detail::BaseSlice,
                                     const uint8_t* begin, const uint8_t* end);
 };
 
+namespace internal {
+template <>
+struct ConstRefSliceCastable<Slice, grpc_slice> {};
+template <>
+struct ConstRefSliceCastable<grpc_slice, Slice> {};
+}  // namespace internal
+
 }  // namespace experimental
 }  // namespace grpc_event_engine
 
diff --git a/include/grpc/event_engine/slice_buffer.h b/include/grpc/event_engine/slice_buffer.h
index 3df3394073c..d2a8ecd81a3 100644
--- a/include/grpc/event_engine/slice_buffer.h
+++ b/include/grpc/event_engine/slice_buffer.h
@@ -25,7 +25,9 @@
 #include "absl/strings/string_view.h"
 #include "absl/utility/utility.h"
 
+#include <grpc/event_engine/internal/slice_cast.h>
 #include <grpc/event_engine/slice.h>
+#include <grpc/impl/codegen/slice.h>
 #include <grpc/slice.h>
 #include <grpc/slice_buffer.h>
 #include <grpc/support/log.h>
@@ -117,6 +119,10 @@ class SliceBuffer {
   /// associated slice.
   Slice RefSlice(size_t index);
 
+  const Slice& operator[](size_t index) const {
+    return internal::SliceCast<Slice>(slice_buffer_.slices[index]);
+  }
+
   /// The total number of bytes held by the SliceBuffer
   size_t Length() { return slice_buffer_.length; }
 
diff --git a/include/grpc/support/port_platform.h b/include/grpc/support/port_platform.h
index 9c9244ce626..9f9cac0054f 100644
--- a/include/grpc/support/port_platform.h
+++ b/include/grpc/support/port_platform.h
@@ -761,6 +761,19 @@ extern void gpr_unreachable_code(const char* reason, const char* file,
 #define __STDC_FORMAT_MACROS
 #endif
 
+/* MSVC doesn't do the empty base class optimization in debug builds by default,
+ * and because of ABI likely won't.
+ * This enables it for specific types, use as:
+ * class GPR_MSVC_EMPTY_BASE_CLASS_WORKAROUND Foo : public A, public B, public C
+ * {}; */
+#ifndef GPR_MSVC_EMPTY_BASE_CLASS_WORKAROUND
+#ifdef GPR_WINDOWS
+#define GPR_MSVC_EMPTY_BASE_CLASS_WORKAROUND __declspec(empty_bases)
+#else
+#define GPR_MSVC_EMPTY_BASE_CLASS_WORKAROUND
+#endif
+#endif
+
 #define GRPC_CALLBACK_API_NONEXPERIMENTAL
 
 /* clang 11 with msan miscompiles destruction of [[no_unique_address]] members
diff --git a/package.xml b/package.xml
index 81c05fa6fa8..9a58ea75f2f 100644
--- a/package.xml
+++ b/package.xml
@@ -36,6 +36,7 @@
     <file baseinstalldir="/" name="include/grpc/event_engine/endpoint_config.h" role="src" />
     <file baseinstalldir="/" name="include/grpc/event_engine/event_engine.h" role="src" />
     <file baseinstalldir="/" name="include/grpc/event_engine/internal/memory_allocator_impl.h" role="src" />
+    <file baseinstalldir="/" name="include/grpc/event_engine/internal/slice_cast.h" role="src" />
     <file baseinstalldir="/" name="include/grpc/event_engine/memory_allocator.h" role="src" />
     <file baseinstalldir="/" name="include/grpc/event_engine/memory_request.h" role="src" />
     <file baseinstalldir="/" name="include/grpc/event_engine/port.h" role="src" />
diff --git a/src/core/BUILD b/src/core/BUILD
index 04ab8a692ba..f779a7ef566 100644
--- a/src/core/BUILD
+++ b/src/core/BUILD
@@ -44,6 +44,13 @@ grpc_cc_library(
     language = "c++",
 )
 
+grpc_cc_library(
+    name = "slice_cast",
+    hdrs = [
+        "//:include/grpc/event_engine/internal/slice_cast.h",
+    ],
+)
+
 grpc_cc_library(
     name = "event_engine_common",
     srcs = [
@@ -65,6 +72,7 @@ grpc_cc_library(
     deps = [
         "slice",
         "slice_buffer",
+        "slice_cast",
         "slice_refcount",
         "//:event_engine_base_hdrs",
         "//:gpr",
@@ -1109,6 +1117,7 @@ grpc_cc_library(
     ],
     visibility = ["@grpc:alt_grpc_base_legacy"],
     deps = [
+        "slice_cast",
         "slice_refcount",
         "//:event_engine_base_hdrs",
         "//:gpr",
diff --git a/src/core/lib/slice/slice.h b/src/core/lib/slice/slice.h
index f95d0d87f1d..1199a7af2f7 100644
--- a/src/core/lib/slice/slice.h
+++ b/src/core/lib/slice/slice.h
@@ -25,6 +25,8 @@
 
 #include "absl/strings/string_view.h"
 
+#include <grpc/event_engine/internal/slice_cast.h>
+#include <grpc/event_engine/slice.h>
 #include <grpc/slice.h>
 #include <grpc/support/log.h>
 
@@ -295,9 +297,10 @@ class MutableSlice : public slice_detail::BaseSlice,
   uint8_t& operator[](size_t i) { return mutable_data()[i]; }
 };
 
-class Slice : public slice_detail::BaseSlice,
-              public slice_detail::CopyConstructors<Slice>,
-              public slice_detail::StaticConstructors<Slice> {
+class GPR_MSVC_EMPTY_BASE_CLASS_WORKAROUND Slice
+    : public slice_detail::BaseSlice,
+      public slice_detail::CopyConstructors<Slice>,
+      public slice_detail::StaticConstructors<Slice> {
  public:
   Slice() = default;
   ~Slice() { CSliceUnref(c_slice()); }
@@ -403,4 +406,19 @@ class Slice : public slice_detail::BaseSlice,
 
 }  // namespace grpc_core
 
+namespace grpc_event_engine {
+namespace experimental {
+namespace internal {
+template <>
+struct ConstRefSliceCastable<grpc_core::Slice, grpc_slice> {};
+template <>
+struct ConstRefSliceCastable<grpc_slice, grpc_core::Slice> {};
+template <>
+struct ConstRefSliceCastable<grpc_core::Slice, Slice> {};
+template <>
+struct ConstRefSliceCastable<Slice, grpc_core::Slice> {};
+}  // namespace internal
+}  // namespace experimental
+}  // namespace grpc_event_engine
+
 #endif  // GRPC_CORE_LIB_SLICE_SLICE_H
diff --git a/src/core/lib/slice/slice_buffer.h b/src/core/lib/slice/slice_buffer.h
index e40246a8455..707247e983f 100644
--- a/src/core/lib/slice/slice_buffer.h
+++ b/src/core/lib/slice/slice_buffer.h
@@ -108,6 +108,11 @@ class SliceBuffer {
   /// associated slice.
   Slice RefSlice(size_t index) const;
 
+  const Slice& operator[](size_t index) const {
+    return grpc_event_engine::experimental::internal::SliceCast<Slice>(
+        slice_buffer_.slices[index]);
+  }
+
   /// The total number of bytes held by the SliceBuffer
   size_t Length() const { return slice_buffer_.length; }
 
diff --git a/test/core/slice/slice_test.cc b/test/core/slice/slice_test.cc
index 5e580b8ba60..0e216aec5cc 100644
--- a/test/core/slice/slice_test.cc
+++ b/test/core/slice/slice_test.cc
@@ -432,6 +432,15 @@ TEST(SliceTest, LetsGetMutable) {
   EXPECT_EQ(slice.as_string_view(), "ifnmp");
 }
 
+TEST(SliceTest, SliceCastWorks) {
+  using ::grpc_event_engine::experimental::internal::SliceCast;
+  Slice test = Slice::FromCopiedString("hello world!");
+  const grpc_slice& slice = SliceCast<grpc_slice>(test);
+  EXPECT_EQ(&slice, &test.c_slice());
+  const Slice& other = SliceCast<Slice>(slice);
+  EXPECT_EQ(&other, &test);
+}
+
 }  // namespace
 }  // namespace grpc_core
 
diff --git a/tools/buildgen/plugins/list_api.py b/tools/buildgen/plugins/list_api.py
index da5ae56126a..63a635a909e 100755
--- a/tools/buildgen/plugins/list_api.py
+++ b/tools/buildgen/plugins/list_api.py
@@ -22,7 +22,7 @@ import sys
 
 import yaml
 
-_RE_API = r'(?:GPRAPI|GRPCAPI|CENSUSAPI)([^;]*);'
+_RE_API = r'(?:GPRAPI|GRPCAPI|CENSUSAPI)([^#;]*);'
 
 
 def list_c_apis(filenames):
diff --git a/tools/doxygen/Doxyfile.c++ b/tools/doxygen/Doxyfile.c++
index a06e4cb11f9..5f4897627b8 100644
--- a/tools/doxygen/Doxyfile.c++
+++ b/tools/doxygen/Doxyfile.c++
@@ -882,6 +882,7 @@ include/grpc/compression.h \
 include/grpc/event_engine/endpoint_config.h \
 include/grpc/event_engine/event_engine.h \
 include/grpc/event_engine/internal/memory_allocator_impl.h \
+include/grpc/event_engine/internal/slice_cast.h \
 include/grpc/event_engine/memory_allocator.h \
 include/grpc/event_engine/memory_request.h \
 include/grpc/event_engine/port.h \
diff --git a/tools/doxygen/Doxyfile.c++.internal b/tools/doxygen/Doxyfile.c++.internal
index a0482b3476f..820db7a49b6 100644
--- a/tools/doxygen/Doxyfile.c++.internal
+++ b/tools/doxygen/Doxyfile.c++.internal
@@ -882,6 +882,7 @@ include/grpc/compression.h \
 include/grpc/event_engine/endpoint_config.h \
 include/grpc/event_engine/event_engine.h \
 include/grpc/event_engine/internal/memory_allocator_impl.h \
+include/grpc/event_engine/internal/slice_cast.h \
 include/grpc/event_engine/memory_allocator.h \
 include/grpc/event_engine/memory_request.h \
 include/grpc/event_engine/port.h \
diff --git a/tools/doxygen/Doxyfile.core b/tools/doxygen/Doxyfile.core
index 69cf9547508..aee1b329959 100644
--- a/tools/doxygen/Doxyfile.core
+++ b/tools/doxygen/Doxyfile.core
@@ -814,6 +814,7 @@ include/grpc/compression.h \
 include/grpc/event_engine/endpoint_config.h \
 include/grpc/event_engine/event_engine.h \
 include/grpc/event_engine/internal/memory_allocator_impl.h \
+include/grpc/event_engine/internal/slice_cast.h \
 include/grpc/event_engine/memory_allocator.h \
 include/grpc/event_engine/memory_request.h \
 include/grpc/event_engine/port.h \
diff --git a/tools/doxygen/Doxyfile.core.internal b/tools/doxygen/Doxyfile.core.internal
index aa12755a652..c758dc95a0f 100644
--- a/tools/doxygen/Doxyfile.core.internal
+++ b/tools/doxygen/Doxyfile.core.internal
@@ -814,6 +814,7 @@ include/grpc/compression.h \
 include/grpc/event_engine/endpoint_config.h \
 include/grpc/event_engine/event_engine.h \
 include/grpc/event_engine/internal/memory_allocator_impl.h \
+include/grpc/event_engine/internal/slice_cast.h \
 include/grpc/event_engine/memory_allocator.h \
 include/grpc/event_engine/memory_request.h \
 include/grpc/event_engine/port.h \