diff --git a/include/grpc/impl/codegen/port_platform.h b/include/grpc/impl/codegen/port_platform.h
index 4f213ff5979..7436e644504 100644
--- a/include/grpc/impl/codegen/port_platform.h
+++ b/include/grpc/impl/codegen/port_platform.h
@@ -112,31 +112,6 @@
 #define GPR_WINDOWS_ATOMIC 1
 #define GPR_MSVC_TLS 1
 #endif
-#elif defined(GPR_MANYLINUX1)
-// TODO(atash): manylinux1 is just another __linux__ but with ancient
-// libraries; it should be integrated with the `__linux__` definitions below.
-#define GPR_PLATFORM_STRING "manylinux"
-#define GPR_POSIX_CRASH_HANDLER 1
-#define GPR_CPU_POSIX 1
-#define GPR_GCC_ATOMIC 1
-#define GPR_GCC_TLS 1
-#define GPR_LINUX 1
-#define GPR_LINUX_LOG 1
-#define GPR_SUPPORT_CHANNELS_FROM_FD 1
-#define GPR_LINUX_ENV 1
-#define GPR_POSIX_TMPFILE 1
-#define GPR_POSIX_STRING 1
-#define GPR_POSIX_SUBPROCESS 1
-#define GPR_POSIX_SYNC 1
-#define GPR_POSIX_TIME 1
-#define GPR_HAS_PTHREAD_H 1
-#define GPR_GETPID_IN_UNISTD_H 1
-#ifdef _LP64
-#define GPR_ARCH_64 1
-#else /* _LP64 */
-#define GPR_ARCH_32 1
-#endif /* _LP64 */
-#include <linux/version.h>
 #elif defined(ANDROID) || defined(__ANDROID__)
 #define GPR_PLATFORM_STRING "android"
 #define GPR_ANDROID 1
diff --git a/src/core/lib/iomgr/port.h b/src/core/lib/iomgr/port.h
index 211423e643d..02f64f318a9 100644
--- a/src/core/lib/iomgr/port.h
+++ b/src/core/lib/iomgr/port.h
@@ -33,19 +33,6 @@
 #endif
 #if defined(GRPC_CUSTOM_SOCKET)
 // Do Nothing
-#elif defined(GPR_MANYLINUX1)
-#define GRPC_HAVE_ARPA_NAMESER 1
-#define GRPC_HAVE_IFADDRS 1
-#define GRPC_HAVE_IPV6_RECVPKTINFO 1
-#define GRPC_HAVE_IP_PKTINFO 1
-#define GRPC_HAVE_MSG_NOSIGNAL 1
-#define GRPC_HAVE_UNIX_SOCKET 1
-#define GRPC_POSIX_FORK 1
-#define GRPC_POSIX_NO_SPECIAL_WAKEUP_FD 1
-#define GRPC_POSIX_SOCKET 1
-#define GRPC_POSIX_SOCKETUTILS 1
-#define GRPC_POSIX_WAKEUP_FD 1
-#define GRPC_LINUX_EPOLL 1
 #elif defined(GPR_WINDOWS)
 #define GRPC_WINSOCK_SOCKET 1
 #define GRPC_WINDOWS_SOCKETUTILS 1
diff --git a/tools/run_tests/artifacts/artifact_targets.py b/tools/run_tests/artifacts/artifact_targets.py
index f748a9a909a..dbc37e6f57c 100644
--- a/tools/run_tests/artifacts/artifact_targets.py
+++ b/tools/run_tests/artifacts/artifact_targets.py
@@ -144,14 +144,8 @@ class PythonArtifact:
             environ['PYTHON'] = '/opt/python/{}/bin/python'.format(
                 self.py_version)
             environ['PIP'] = '/opt/python/{}/bin/pip'.format(self.py_version)
-            # Platform autodetection for the manylinux1 image breaks so we set the
-            # defines ourselves.
-            # TODO(atash) get better platform-detection support in core so we don't
-            # need to do this manually...
-            environ['CFLAGS'] = '-DGPR_MANYLINUX1=1'
             environ['GRPC_BUILD_GRPCIO_TOOLS_DEPENDENTS'] = 'TRUE'
             environ['GRPC_BUILD_MANYLINUX_WHEEL'] = 'TRUE'
-
             return create_docker_jobspec(
                 self.name,
                 # NOTE(rbellevi): Do *not* update this without also ensuring the
@@ -160,9 +154,7 @@ class PythonArtifact:
                 (self.platform, self.arch),
                 'tools/run_tests/artifacts/build_artifact_python.sh',
                 environ=environ,
-                timeout_seconds=60 * 60,
-                docker_base_image='quay.io/pypa/manylinux1_i686'
-                if self.arch == 'x86' else 'quay.io/pypa/manylinux1_x86_64')
+                timeout_seconds=60 * 60)
         elif self.platform == 'windows':
             if 'Python27' in self.py_version:
                 environ['EXT_COMPILER'] = 'mingw32'