diff --git a/src/python/grpcio_tests/tests_py3_only/interop/build_server_image.sh b/src/python/grpcio_tests/tests_py3_only/interop/build_server_image.sh
deleted file mode 100755
index ad62ced6903..00000000000
--- a/src/python/grpcio_tests/tests_py3_only/interop/build_server_image.sh
+++ /dev/null
@@ -1,28 +0,0 @@
-# Copyright 2021 The gRPC authors.
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-#!/bin/bash
-
-set -x
-
-VERSION=$(git rev-parse HEAD)
-
-PROJECT=grpc-testing
-TAG=gcr.io/${PROJECT}/python_xds_interop_server:$VERSION
-
-cd "$(dirname "${BASH_SOURCE[0]}")/../../../../.."
-
-docker build \
-    -t ${TAG} \
-    -f src/python/grpcio_tests/tests_py3_only/interop/Dockerfile.server \
-    .
diff --git a/src/python/grpcio_tests/tests_py3_only/interop/build_client_image.sh b/tools/internal_ci/linux/grpc_xds_k8s_python.cfg
old mode 100755
new mode 100644
similarity index 58%
rename from src/python/grpcio_tests/tests_py3_only/interop/build_client_image.sh
rename to tools/internal_ci/linux/grpc_xds_k8s_python.cfg
index 83c2d6ec4a2..64bd5df4540
--- a/src/python/grpcio_tests/tests_py3_only/interop/build_client_image.sh
+++ b/tools/internal_ci/linux/grpc_xds_k8s_python.cfg
@@ -1,4 +1,4 @@
-# Copyright 2021 The gRPC authors.
+# Copyright 2021 gRPC authors.
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
@@ -11,18 +11,16 @@
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
-#!/bin/bash
 
-set -x
+# Config file for the internal CI (in protobuf text format)
 
-VERSION=$(git rev-parse HEAD)
-
-PROJECT=grpc-testing
-TAG=gcr.io/${PROJECT}/python_xds_interop_client:$VERSION
-
-cd "$(dirname "${BASH_SOURCE[0]}")/../../../../.."
-
-docker build \
-    -t ${TAG} \
-    -f src/python/grpcio_tests/tests_py3_only/interop/Dockerfile.client \
-    .
+# Location of the continuous shell script in repository.
+build_file: "grpc/tools/internal_ci/linux/grpc_xds_k8s_python.sh"
+timeout_mins: 180
+action {
+  define_artifacts {
+    regex: "artifacts/**/*sponge_log.xml"
+    regex: "artifacts/**/*sponge_log.log"
+    strip_prefix: "artifacts"
+  }
+}
diff --git a/tools/internal_ci/linux/grpc_xds_k8s_python.sh b/tools/internal_ci/linux/grpc_xds_k8s_python.sh
new file mode 100755
index 00000000000..04411387d03
--- /dev/null
+++ b/tools/internal_ci/linux/grpc_xds_k8s_python.sh
@@ -0,0 +1,165 @@
+#!/usr/bin/env bash
+# Copyright 2021 gRPC authors.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+set -ex -o igncr || set -ex
+
+# Constants
+readonly GITHUB_REPOSITORY_NAME="grpc"
+# GKE Cluster
+readonly GKE_CLUSTER_NAME="interop-test-psm-sec-testing-api"
+readonly GKE_CLUSTER_ZONE="us-west1-b"
+export CLOUDSDK_API_ENDPOINT_OVERRIDES_CONTAINER="https://test-container.sandbox.googleapis.com/"
+## xDS test server/client Docker images
+readonly SERVER_IMAGE_NAME="gcr.io/grpc-testing/xds-interop/python-server"
+readonly CLIENT_IMAGE_NAME="gcr.io/grpc-testing/xds-interop/python-client"
+readonly FORCE_IMAGE_BUILD="${FORCE_IMAGE_BUILD:-0}"
+readonly BUILD_APP_PATH="interop-testing/build/install/grpc-interop-testing"
+readonly TEST_DRIVER_REPO_DIR_USE_EXISTING=1
+readonly LANGUAGE_NAME="Python"
+
+#######################################
+# Builds test app Docker images and pushes them to GCR
+# Globals:
+#   BUILD_APP_PATH
+#   SERVER_IMAGE_NAME: Test server Docker image name
+#   CLIENT_IMAGE_NAME: Test client Docker image name
+#   GIT_COMMIT: SHA-1 of git commit being built
+# Arguments:
+#   None
+# Outputs:
+#   Writes the output of `gcloud builds submit` to stdout, stderr
+#######################################
+build_test_app_docker_images() {
+  echo "Building ${LANGUAGE_NAME} xDS interop test app Docker images"
+
+  pushd "${SRC_DIR}"
+  docker build \
+    -f src/python/grpcio_tests/tests_py3_only/interop/Dockerfile.client \
+    -t "${CLIENT_IMAGE_NAME}:${GIT_COMMIT}" \
+    .
+
+  docker build \
+    -f src/python/grpcio_tests/tests_py3_only/interop/Dockerfile.server \
+    -t "${SERVER_IMAGE_NAME}:${GIT_COMMIT}" \
+    .
+
+  popd
+
+  gcloud -q auth configure-docker
+
+  docker push "${CLIENT_IMAGE_NAME}:${GIT_COMMIT}"
+  docker push "${SERVER_IMAGE_NAME}:${GIT_COMMIT}"
+}
+
+#######################################
+# Builds test app and its docker images unless they already exist
+# Globals:
+#   SERVER_IMAGE_NAME: Test server Docker image name
+#   CLIENT_IMAGE_NAME: Test client Docker image name
+#   GIT_COMMIT: SHA-1 of git commit being built
+#   FORCE_IMAGE_BUILD
+# Arguments:
+#   None
+# Outputs:
+#   Writes the output to stdout, stderr
+#######################################
+build_docker_images_if_needed() {
+  # Check if images already exist
+  server_tags="$(gcloud_gcr_list_image_tags "${SERVER_IMAGE_NAME}" "${GIT_COMMIT}")"
+  printf "Server image: %s:%s\n" "${SERVER_IMAGE_NAME}" "${GIT_COMMIT}"
+  echo "${server_tags:-Server image not found}"
+
+  client_tags="$(gcloud_gcr_list_image_tags "${CLIENT_IMAGE_NAME}" "${GIT_COMMIT}")"
+  printf "Client image: %s:%s\n" "${CLIENT_IMAGE_NAME}" "${GIT_COMMIT}"
+  echo "${client_tags:-Client image not found}"
+
+  # Build if any of the images are missing, or FORCE_IMAGE_BUILD=1
+  if [[ "${FORCE_IMAGE_BUILD}" == "1" || -z "${server_tags}" || -z "${client_tags}" ]]; then
+    build_test_app_docker_images
+  else
+    echo "Skipping ${LANGUAGE_NAME} test app build"
+  fi
+}
+
+#######################################
+# Executes the test case
+# Globals:
+#   TEST_DRIVER_FLAGFILE: Relative path to test driver flagfile
+#   KUBE_CONTEXT: The name of kubectl context with GKE cluster access
+#   TEST_XML_OUTPUT_DIR: Output directory for the test xUnit XML report
+#   SERVER_IMAGE_NAME: Test server Docker image name
+#   CLIENT_IMAGE_NAME: Test client Docker image name
+#   GIT_COMMIT: SHA-1 of git commit being built
+# Arguments:
+#   Test case name
+# Outputs:
+#   Writes the output of test execution to stdout, stderr
+#   Test xUnit report to ${TEST_XML_OUTPUT_DIR}/${test_name}/sponge_log.xml
+#######################################
+run_test() {
+  # Test driver usage:
+  # https://github.com/grpc/grpc/tree/master/tools/run_tests/xds_k8s_test_driver#basic-usage
+  local test_name="${1:?Usage: run_test test_name}"
+  set -x
+  python -m "tests.${test_name}" \
+    --flagfile="${TEST_DRIVER_FLAGFILE}" \
+    --kube_context="${KUBE_CONTEXT}" \
+    --server_image="${SERVER_IMAGE_NAME}:${GIT_COMMIT}" \
+    --client_image="${CLIENT_IMAGE_NAME}:${GIT_COMMIT}" \
+    --xml_output_file="${TEST_XML_OUTPUT_DIR}/${test_name}/sponge_log.xml" \
+    --force_cleanup \
+    --nocheck_local_certs
+  set +x
+}
+
+#######################################
+# Main function: provision software necessary to execute tests, and run them
+# Globals:
+#   KOKORO_ARTIFACTS_DIR
+#   GITHUB_REPOSITORY_NAME
+#   SRC_DIR: Populated with absolute path to the source repo
+#   TEST_DRIVER_REPO_DIR: Populated with the path to the repo containing
+#                         the test driver
+#   TEST_DRIVER_FULL_DIR: Populated with the path to the test driver source code
+#   TEST_DRIVER_FLAGFILE: Populated with relative path to test driver flagfile
+#   TEST_XML_OUTPUT_DIR: Populated with the path to test xUnit XML report
+#   GIT_ORIGIN_URL: Populated with the origin URL of git repo used for the build
+#   GIT_COMMIT: Populated with the SHA-1 of git commit being built
+#   GIT_COMMIT_SHORT: Populated with the short SHA-1 of git commit being built
+#   KUBE_CONTEXT: Populated with name of kubectl context with GKE cluster access
+# Arguments:
+#   None
+# Outputs:
+#   Writes the output of test execution to stdout, stderr
+#######################################
+main() {
+  local script_dir
+  script_dir="$(dirname "$0")"
+  # shellcheck source=tools/internal_ci/linux/grpc_xds_k8s_install_test_driver.sh
+  source "${script_dir}/grpc_xds_k8s_install_test_driver.sh"
+  set -x
+  if [[ -n "${KOKORO_ARTIFACTS_DIR}" ]]; then
+    kokoro_setup_test_driver "${GITHUB_REPOSITORY_NAME}"
+  else
+    local_setup_test_driver "${script_dir}"
+  fi
+  build_docker_images_if_needed
+  # Run tests
+  cd "${TEST_DRIVER_FULL_DIR}"
+  run_test baseline_test
+  run_test security_test
+}
+
+main "$@"