diff --git a/examples/python/cancellation/BUILD.bazel b/examples/python/cancellation/BUILD.bazel
index 2c50f5b47cc..5215991c5ff 100644
--- a/examples/python/cancellation/BUILD.bazel
+++ b/examples/python/cancellation/BUILD.bazel
@@ -43,8 +43,8 @@ py_binary(
     deps = [
         ":hash_name_py_pb2",
         ":hash_name_py_pb2_grpc",
-        "@six//:six",
         "//src/python/grpcio/grpc:grpcio",
+        "@six",
     ],
 )
 
diff --git a/src/python/grpcio/grpc/framework/foundation/BUILD.bazel b/src/python/grpcio/grpc/framework/foundation/BUILD.bazel
index 6a353573a4a..4a71183c53c 100644
--- a/src/python/grpcio/grpc/framework/foundation/BUILD.bazel
+++ b/src/python/grpcio/grpc/framework/foundation/BUILD.bazel
@@ -33,7 +33,7 @@ py_library(
     name = "future",
     srcs = ["future.py"],
     deps = [
-        "@six//:six",
+        "@six",
     ],
 )
 
@@ -58,6 +58,6 @@ py_library(
     name = "stream",
     srcs = ["stream.py"],
     deps = [
-        "@six//:six",
+        "@six",
     ],
 )
diff --git a/src/python/grpcio_tests/tests/unit/BUILD.bazel b/src/python/grpcio_tests/tests/unit/BUILD.bazel
index 8a42e5fc99a..42b99023463 100644
--- a/src/python/grpcio_tests/tests/unit/BUILD.bazel
+++ b/src/python/grpcio_tests/tests/unit/BUILD.bazel
@@ -102,10 +102,10 @@ py_library(
             ":resources",
             ":test_common",
             ":thread_pool",
-            "@six//:six",
             "//src/python/grpcio/grpc:grpcio",
             "//src/python/grpcio_tests/tests/testing",
             "//src/python/grpcio_tests/tests/unit/framework/common",
+            "@six",
         ],
     )
     for test_file_name in GRPCIO_TESTS_UNIT
diff --git a/src/python/grpcio_tests/tests_aio/benchmark/BUILD.bazel b/src/python/grpcio_tests/tests_aio/benchmark/BUILD.bazel
index 2957941b8c0..992b850c353 100644
--- a/src/python/grpcio_tests/tests_aio/benchmark/BUILD.bazel
+++ b/src/python/grpcio_tests/tests_aio/benchmark/BUILD.bazel
@@ -22,11 +22,11 @@ py_binary(
     srcs = ["server.py"],
     python_version = "PY3",
     deps = [
-        "@six//:six",
         "//src/proto/grpc/testing:benchmark_service_py_pb2",
         "//src/proto/grpc/testing:benchmark_service_py_pb2_grpc",
         "//src/proto/grpc/testing:py_messages_proto",
         "//src/python/grpcio/grpc:grpcio",
         "//src/python/grpcio_tests/tests/unit/framework/common",
+        "@six",
     ],
 )
diff --git a/src/python/grpcio_tests/tests_aio/unit/BUILD.bazel b/src/python/grpcio_tests/tests_aio/unit/BUILD.bazel
index 650132d1030..b6743e2ec31 100644
--- a/src/python/grpcio_tests/tests_aio/unit/BUILD.bazel
+++ b/src/python/grpcio_tests/tests_aio/unit/BUILD.bazel
@@ -58,12 +58,12 @@ py_library(
             ":_constants",
             ":_test_base",
             ":_test_server",
-            "@six//:six",
             "//src/proto/grpc/testing:benchmark_service_py_pb2",
             "//src/proto/grpc/testing:benchmark_service_py_pb2_grpc",
             "//src/proto/grpc/testing:py_messages_proto",
             "//src/python/grpcio/grpc:grpcio",
             "//src/python/grpcio_tests/tests/unit/framework/common",
+            "@six",
         ],
     )
     for test_file_name in GRPC_ASYNC_TESTS