diff --git a/test/cpp/end2end/xds_end2end_test.cc b/test/cpp/end2end/xds_end2end_test.cc
index 8ce46c59169..d408f345f48 100644
--- a/test/cpp/end2end/xds_end2end_test.cc
+++ b/test/cpp/end2end/xds_end2end_test.cc
@@ -54,6 +54,7 @@
 #include "src/core/ext/xds/xds_client.h"
 #include "src/core/lib/channel/channel_args.h"
 #include "src/core/lib/gpr/env.h"
+#include "src/core/lib/gpr/time_precise.h"
 #include "src/core/lib/gpr/tmpfile.h"
 #include "src/core/lib/gprpp/ref_counted_ptr.h"
 #include "src/core/lib/gprpp/sync.h"
@@ -4463,11 +4464,9 @@ TEST_P(LdsRdsTest, XdsRoutingClusterUpdateClustersWithPickingDelays) {
 }
 
 TEST_P(LdsRdsTest, XdsRoutingApplyXdsTimeout) {
-  // TODO(https://github.com/grpc/grpc/issues/24549): TSAN won't work here.
-  if (BuiltUnderAsan() || BuiltUnderTsan()) return;
-
   gpr_setenv("GRPC_XDS_EXPERIMENTAL_ENABLE_TIMEOUT", "true");
-  const int64_t kTimeoutNano = 500000000;
+  const int64_t kTimeoutMillis = 500;
+  const int64_t kTimeoutNano = kTimeoutMillis * 1000000;
   const int64_t kTimeoutGrpcTimeoutHeaderMaxSecond = 1;
   const int64_t kTimeoutMaxStreamDurationSecond = 2;
   const int64_t kTimeoutHttpMaxStreamDurationSecond = 3;
@@ -4557,7 +4556,11 @@ TEST_P(LdsRdsTest, XdsRoutingApplyXdsTimeout) {
   // Set listener and route config.
   SetListenerAndRouteConfiguration(0, std::move(listener), new_route_config);
   // Test grpc_timeout_header_max of 1.5 seconds applied
-  auto t0 = system_clock::now();
+  gpr_cycle_counter now = gpr_get_cycle_counter();
+  grpc_millis t0 = grpc_cycle_counter_to_millis_round_up(now);
+  grpc_millis t1 =
+      t0 + kTimeoutGrpcTimeoutHeaderMaxSecond * 1000 + kTimeoutMillis;
+  grpc_millis t2 = t0 + kTimeoutMaxStreamDurationSecond * 1000 + kTimeoutMillis;
   CheckRpcSendFailure(1,
                       RpcOptions()
                           .set_rpc_service(SERVICE_ECHO1)
@@ -4565,15 +4568,15 @@ TEST_P(LdsRdsTest, XdsRoutingApplyXdsTimeout) {
                           .set_wait_for_ready(true)
                           .set_timeout_ms(kTimeoutApplicationSecond * 1000),
                       StatusCode::DEADLINE_EXCEEDED);
-  auto ellapsed_nano_seconds =
-      std::chrono::duration_cast<std::chrono::nanoseconds>(system_clock::now() -
-                                                           t0);
-  EXPECT_GT(ellapsed_nano_seconds.count(),
-            kTimeoutGrpcTimeoutHeaderMaxSecond * 1000000000 + kTimeoutNano);
-  EXPECT_LT(ellapsed_nano_seconds.count(),
-            kTimeoutMaxStreamDurationSecond * 1000000000);
+  now = gpr_get_cycle_counter();
+  t0 = grpc_cycle_counter_to_millis_round_up(now);
+  EXPECT_GE(t0, t1);
+  EXPECT_LT(t0, t2);
   // Test max_stream_duration of 2.5 seconds applied
-  t0 = system_clock::now();
+  now = gpr_get_cycle_counter();
+  t0 = grpc_cycle_counter_to_millis_round_up(now);
+  t1 = t0 + kTimeoutMaxStreamDurationSecond * 1000 + kTimeoutMillis;
+  t2 = t0 + kTimeoutHttpMaxStreamDurationSecond * 1000 + kTimeoutMillis;
   CheckRpcSendFailure(1,
                       RpcOptions()
                           .set_rpc_service(SERVICE_ECHO2)
@@ -4581,24 +4584,23 @@ TEST_P(LdsRdsTest, XdsRoutingApplyXdsTimeout) {
                           .set_wait_for_ready(true)
                           .set_timeout_ms(kTimeoutApplicationSecond * 1000),
                       StatusCode::DEADLINE_EXCEEDED);
-  ellapsed_nano_seconds = std::chrono::duration_cast<std::chrono::nanoseconds>(
-      system_clock::now() - t0);
-  EXPECT_GT(ellapsed_nano_seconds.count(),
-            kTimeoutMaxStreamDurationSecond * 1000000000 + kTimeoutNano);
-  EXPECT_LT(ellapsed_nano_seconds.count(),
-            kTimeoutHttpMaxStreamDurationSecond * 1000000000);
+  now = gpr_get_cycle_counter();
+  t0 = grpc_cycle_counter_to_millis_round_up(now);
+  EXPECT_GE(t0, t1);
+  EXPECT_LT(t0, t2);
   // Test http_stream_duration of 3.5 seconds applied
-  t0 = system_clock::now();
+  now = gpr_get_cycle_counter();
+  t0 = grpc_cycle_counter_to_millis_round_up(now);
+  t1 = t0 + kTimeoutHttpMaxStreamDurationSecond * 1000 + kTimeoutMillis;
+  t2 = t0 + kTimeoutApplicationSecond * 1000 + kTimeoutMillis;
   CheckRpcSendFailure(1,
                       RpcOptions().set_wait_for_ready(true).set_timeout_ms(
                           kTimeoutApplicationSecond * 1000),
                       StatusCode::DEADLINE_EXCEEDED);
-  ellapsed_nano_seconds = std::chrono::duration_cast<std::chrono::nanoseconds>(
-      system_clock::now() - t0);
-  EXPECT_GT(ellapsed_nano_seconds.count(),
-            kTimeoutHttpMaxStreamDurationSecond * 1000000000 + kTimeoutNano);
-  EXPECT_LT(ellapsed_nano_seconds.count(),
-            kTimeoutApplicationSecond * 1000000000);
+  now = gpr_get_cycle_counter();
+  t0 = grpc_cycle_counter_to_millis_round_up(now);
+  EXPECT_GE(t0, t1);
+  EXPECT_LT(t0, t2);
   gpr_unsetenv("GRPC_XDS_EXPERIMENTAL_ENABLE_TIMEOUT");
 }