diff --git a/src/core/BUILD b/src/core/BUILD
index 7e33aba1571..4e59c1dc97c 100644
--- a/src/core/BUILD
+++ b/src/core/BUILD
@@ -4032,6 +4032,7 @@ grpc_cc_library(
         "context",
         "delegating_helper",
         "error",
+        "experiments",
         "gpr_atm",
         "grpc_sockaddr",
         "json",
@@ -5042,6 +5043,7 @@ grpc_cc_library(
     deps = [
         "channel_args",
         "delegating_helper",
+        "experiments",
         "grpc_outlier_detection_header",
         "health_check_client",
         "iomgr_fwd",
@@ -5172,6 +5174,7 @@ grpc_cc_library(
         "closure",
         "delegating_helper",
         "error",
+        "experiments",
         "grpc_stateful_session_filter",
         "grpc_xds_client",
         "iomgr_fwd",
diff --git a/src/core/ext/filters/client_channel/lb_policy/grpclb/grpclb.cc b/src/core/ext/filters/client_channel/lb_policy/grpclb/grpclb.cc
index b9db3eeade3..0655b2dfc45 100644
--- a/src/core/ext/filters/client_channel/lb_policy/grpclb/grpclb.cc
+++ b/src/core/ext/filters/client_channel/lb_policy/grpclb/grpclb.cc
@@ -107,6 +107,7 @@
 #include "src/core/lib/channel/channelz.h"
 #include "src/core/lib/config/core_configuration.h"
 #include "src/core/lib/debug/trace.h"
+#include "src/core/lib/experiments/experiments.h"
 #include "src/core/lib/gpr/string.h"
 #include "src/core/lib/gpr/useful.h"
 #include "src/core/lib/gprpp/crash.h"
@@ -318,10 +319,22 @@ class GrpcLb : public LoadBalancingPolicy {
           lb_token_(std::move(lb_token)),
           client_stats_(std::move(client_stats)) {}
 
-    ~SubchannelWrapper() override {
-      if (!lb_policy_->shutting_down_) {
-        lb_policy_->CacheDeletedSubchannelLocked(wrapped_subchannel());
+    void Orphan() override {
+      if (!IsClientChannelSubchannelWrapperWorkSerializerOrphanEnabled()) {
+        if (!lb_policy_->shutting_down_) {
+          lb_policy_->CacheDeletedSubchannelLocked(wrapped_subchannel());
+        }
+        return;
       }
+      WeakRefCountedPtr<SubchannelWrapper> self = WeakRef();
+      lb_policy_->work_serializer()->Run(
+          [self = std::move(self)]() {
+            if (!self->lb_policy_->shutting_down_) {
+              self->lb_policy_->CacheDeletedSubchannelLocked(
+                  self->wrapped_subchannel());
+            }
+          },
+          DEBUG_LOCATION);
     }
 
     const std::string& lb_token() const { return lb_token_; }
diff --git a/src/core/ext/filters/client_channel/lb_policy/outlier_detection/outlier_detection.cc b/src/core/ext/filters/client_channel/lb_policy/outlier_detection/outlier_detection.cc
index 8b52dbe8108..aede6d5067d 100644
--- a/src/core/ext/filters/client_channel/lb_policy/outlier_detection/outlier_detection.cc
+++ b/src/core/ext/filters/client_channel/lb_policy/outlier_detection/outlier_detection.cc
@@ -49,6 +49,7 @@
 #include "src/core/lib/channel/channel_args.h"
 #include "src/core/lib/config/core_configuration.h"
 #include "src/core/lib/debug/trace.h"
+#include "src/core/lib/experiments/experiments.h"
 #include "src/core/lib/gprpp/debug_location.h"
 #include "src/core/lib/gprpp/orphanable.h"
 #include "src/core/lib/gprpp/ref_counted.h"
@@ -123,9 +124,11 @@ class OutlierDetectionLb : public LoadBalancingPolicy {
   class SubchannelState;
   class SubchannelWrapper : public DelegatingSubchannel {
    public:
-    SubchannelWrapper(RefCountedPtr<SubchannelState> subchannel_state,
+    SubchannelWrapper(std::shared_ptr<WorkSerializer> work_serializer,
+                      RefCountedPtr<SubchannelState> subchannel_state,
                       RefCountedPtr<SubchannelInterface> subchannel)
         : DelegatingSubchannel(std::move(subchannel)),
+          work_serializer_(std::move(work_serializer)),
           subchannel_state_(std::move(subchannel_state)) {
       if (subchannel_state_ != nullptr) {
         subchannel_state_->AddSubchannel(this);
@@ -135,10 +138,21 @@ class OutlierDetectionLb : public LoadBalancingPolicy {
       }
     }
 
-    ~SubchannelWrapper() override {
-      if (subchannel_state_ != nullptr) {
-        subchannel_state_->RemoveSubchannel(this);
+    void Orphan() override {
+      if (!IsClientChannelSubchannelWrapperWorkSerializerOrphanEnabled()) {
+        if (subchannel_state_ != nullptr) {
+          subchannel_state_->RemoveSubchannel(this);
+        }
+        return;
       }
+      WeakRefCountedPtr<SubchannelWrapper> self = WeakRef();
+      work_serializer_->Run(
+          [self = std::move(self)]() {
+            if (self->subchannel_state_ != nullptr) {
+              self->subchannel_state_->RemoveSubchannel(self.get());
+            }
+          },
+          DEBUG_LOCATION);
     }
 
     void Eject();
@@ -206,6 +220,7 @@ class OutlierDetectionLb : public LoadBalancingPolicy {
       bool ejected_;
     };
 
+    std::shared_ptr<WorkSerializer> work_serializer_;
     RefCountedPtr<SubchannelState> subchannel_state_;
     bool ejected_ = false;
     WatcherWrapper* watcher_wrapper_ = nullptr;
@@ -716,8 +731,9 @@ RefCountedPtr<SubchannelInterface> OutlierDetectionLb::Helper::CreateSubchannel(
     }
   }
   auto subchannel = MakeRefCounted<SubchannelWrapper>(
-      subchannel_state, parent()->channel_control_helper()->CreateSubchannel(
-                            std::move(address), args));
+      parent()->work_serializer(), subchannel_state,
+      parent()->channel_control_helper()->CreateSubchannel(std::move(address),
+                                                           args));
   if (subchannel_state != nullptr) {
     subchannel_state->AddSubchannel(subchannel.get());
   }
diff --git a/src/core/ext/filters/client_channel/lb_policy/xds/xds_override_host.cc b/src/core/ext/filters/client_channel/lb_policy/xds/xds_override_host.cc
index 02949cac379..7c210284aad 100644
--- a/src/core/ext/filters/client_channel/lb_policy/xds/xds_override_host.cc
+++ b/src/core/ext/filters/client_channel/lb_policy/xds/xds_override_host.cc
@@ -29,6 +29,7 @@
 #include <set>
 #include <string>
 #include <tuple>
+#include <type_traits>
 #include <utility>
 #include <vector>
 
@@ -51,6 +52,7 @@
 #include "src/core/lib/channel/channel_args.h"
 #include "src/core/lib/config/core_configuration.h"
 #include "src/core/lib/debug/trace.h"
+#include "src/core/lib/experiments/experiments.h"
 #include "src/core/lib/gprpp/debug_location.h"
 #include "src/core/lib/gprpp/match.h"
 #include "src/core/lib/gprpp/orphanable.h"
@@ -717,8 +719,19 @@ void XdsOverrideHostLb::SubchannelWrapper::UpdateConnectivityState(
 }
 
 void XdsOverrideHostLb::SubchannelWrapper::Orphan() {
-  key_.reset();
-  wrapped_subchannel()->CancelConnectivityStateWatch(watcher_);
+  if (!IsClientChannelSubchannelWrapperWorkSerializerOrphanEnabled()) {
+    key_.reset();
+    wrapped_subchannel()->CancelConnectivityStateWatch(watcher_);
+    return;
+  }
+  WeakRefCountedPtr<SubchannelWrapper> self = WeakRef();
+  policy_->work_serializer()->Run(
+      [self = std::move(self)]() {
+        self->key_.reset();
+        self->wrapped_subchannel()->CancelConnectivityStateWatch(
+            self->watcher_);
+      },
+      DEBUG_LOCATION);
 }
 
 grpc_pollset_set* XdsOverrideHostLb::SubchannelWrapper::