diff --git a/tools/interop_matrix/README.md b/tools/interop_matrix/README.md
index a3717a5a70e..588afe4fd46 100644
--- a/tools/interop_matrix/README.md
+++ b/tools/interop_matrix/README.md
@@ -24,7 +24,7 @@ For more details on each step, refer to sections below.
 - Create new `Dockerfile.template`, `build_interop.sh.template` for the language/runtime under `template/tools/dockerfile/`.
 - Run `tools/buildgen/generate_projects.sh` to create corresponding files under `tools/dockerfile/`.
 - Add language/runtimes to `client_matrix.py` following existing language/runtimes examples.
-- Run `tools/interop_matrix/create_matrix_images.py` which will build and upload images to GCR.  Unless you are also building images for a gRPC release, make sure not to set `--gcr_tag` (the default tag 'master' is used for testing).
+- Run `tools/interop_matrix/create_matrix_images.py` which will build and upload images to GCR.  Unless you are also building images for a gRPC release, make sure not to set `--release` (the default release 'master' is used for testing).
 
 *: Please delete your docker images at https://pantheon.corp.google.com/gcr/images/grpc-testing?project=grpc-testing afterwards.  Permissions to access GrpcTesting project is required for this step.
 
diff --git a/tools/interop_matrix/client_matrix.py b/tools/interop_matrix/client_matrix.py
index 23c5ae00c1c..268b74bc0d4 100644
--- a/tools/interop_matrix/client_matrix.py
+++ b/tools/interop_matrix/client_matrix.py
@@ -27,6 +27,9 @@ LANG_RUNTIME_MATRIX = {
     'cxx': ['cxx'],             # This is actually debian8.
     'go': ['go1.7', 'go1.8'],
     'java': ['java_oracle8'],
+    'python': ['python2.7', 'python3'],
+    'node': ['node8'],
+    'ruby': ['ruby'],
 }
 
 # Dictionary of releases per language.  For each language, we need to provide
@@ -59,4 +62,30 @@ LANG_RELEASE_MATRIX = {
         'v1.6.1',
         'v1.7.0',
     ],
+    'python': [
+        #'v1.0.1',  #Fail to build. Investigating.
+        'v1.1.4',
+        'v1.2.5',
+        'v1.3.9',
+        'v1.4.2',
+        'v1.6.6',
+    ],
+    # Fail to build
+    'node': [
+    #    'v1.0.1', 
+    #    'v1.1.4',
+    #    'v1.2.5',
+    #    'v1.3.9',
+    #    'v1.4.2',
+        'v1.6.6',
+    ],
+    'ruby': [
+        #'v1.0.1',  Can't run the tests because with_rvm.sh is missing.
+        'v1.1.4',
+        'v1.2.5',
+        'v1.3.9',
+        'v1.4.2',
+        'v1.6.6',
+    ],
+
 }
diff --git a/tools/interop_matrix/create_matrix_images.py b/tools/interop_matrix/create_matrix_images.py
index 67355e7fbf9..69463784c76 100755
--- a/tools/interop_matrix/create_matrix_images.py
+++ b/tools/interop_matrix/create_matrix_images.py
@@ -177,10 +177,22 @@ def build_all_images_for_release(lang, release):
     var ={'go': 'GRPC_GO_ROOT', 'java': 'GRPC_JAVA_ROOT', 'node': 'GRPC_NODE_ROOT'}.get(lang, 'GRPC_ROOT')
     env[var] = stack_base
 
-  for runtime in client_matrix.LANG_RUNTIME_MATRIX[lang]:
+  # Python and Node only have one docker template.
+  if 'python' in lang:
+    runtime = 'python'
     job = build_image_jobspec(runtime, env, release)
     docker_images.append(job.tag)
     build_jobs.append(job)
+  elif 'node' in lang:
+    runtime = 'node'
+    job = build_image_jobspec(runtime, env, release)
+    docker_images.append(job.tag)
+    build_jobs.append(job)
+  else:
+    for runtime in client_matrix.LANG_RUNTIME_MATRIX[lang]:
+      job = build_image_jobspec(runtime, env, release)
+      docker_images.append(job.tag)
+      build_jobs.append(job)
 
   jobset.message('START', 'Building interop docker images.', do_newline=True)
   print('Jobs to run: \n%s\n' % '\n'.join(str(j) for j in build_jobs))
diff --git a/tools/interop_matrix/create_testcases.sh b/tools/interop_matrix/create_testcases.sh
index 3d34b2ef25a..2ea2d3ad908 100755
--- a/tools/interop_matrix/create_testcases.sh
+++ b/tools/interop_matrix/create_testcases.sh
@@ -31,11 +31,16 @@ TESTCASES_DIR=${GRPC_ROOT}/tools/interop_matrix/testcases
 
 echo "Create '$LANG' test cases for gRPC release '${RELEASE:=master}'"
 
-echo $client_lang
 # Invoke run_interop_test in manual mode.
 # TODO(adelez): Add cloud_gateways when we figure out how to skip them if not 
 # running in GCE.
-${GRPC_ROOT}/tools/run_tests/run_interop_tests.py -l $LANG --use_docker \
+if [ $LANG == "cxx" ]; then
+client_lang="c++"
+else
+client_lang=$LANG
+fi
+echo $client_lang
+${GRPC_ROOT}/tools/run_tests/run_interop_tests.py -l $client_lang --use_docker \
   --cloud_to_prod --prod_servers default gateway_v4 --manual_run
 
 # Clean up
@@ -59,14 +64,8 @@ trap cleanup EXIT
 # Running the testcases as sanity unless we are asked to skip.
 [ -z "$SKIP_TEST" ] && (echo "Running test cases: $CMDS_SH"; sh $CMDS_SH)
 
-# Convert c++ to cxx. 
-if [$LANG == "c++" ]; then
-client_lang="cxx"
-else
-client_lang=$LANG
-fi
 mkdir -p $TESTCASES_DIR
-testcase=$TESTCASES_DIR/${client_lang}__$RELEASE
+testcase=$TESTCASES_DIR/${LANG}__$RELEASE
 if [ -e $testcase ]; then
   echo "Updating: $testcase"
   diff $testcase $CMDS_SH || true
diff --git a/tools/interop_matrix/testcases/ruby__master b/tools/interop_matrix/testcases/ruby__master
new file mode 100755
index 00000000000..07bfd058666
--- /dev/null
+++ b/tools/interop_matrix/testcases/ruby__master
@@ -0,0 +1,20 @@
+#!/bin/bash
+echo "Testing ${docker_image:=grpc_interop_ruby:6bd1f0eb-51a4-4ad8-861c-1cbd7a929f33}"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=large_unary"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_unary"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=ping_pong"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_stream"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=client_streaming"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=server_streaming"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_begin"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_first_response"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=timeout_on_sleeping_server"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=large_unary"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_unary"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=ping_pong"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=empty_stream"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=client_streaming"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=server_streaming"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_begin"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=cancel_after_first_response"
+docker run -i --rm=true -w /var/local/git/grpc --net=host $docker_image bash -c "tools/run_tests/interop/with_rvm.sh ruby src/ruby/pb/test/client.rb --server_host=216.239.32.254 --server_host_override=grpc-test4.sandbox.googleapis.com --server_port=443 --use_tls=true --test_case=timeout_on_sleeping_server"